IP Library › Granted Patent US 11,576,999
Granted Patent B2
US 11,576,999 · App. 16/988,078 · Granted Feb 14, 2023

Compressed bone composition and methods of use thereof

Inventors: Michael Francis (Virginia Beach, VA); Rudy Rodriquez (Virginia Beach, VA); Nathan Kemper (Virginia Beach, VA); Silvia Chen (Kendall Park, NJ)
Assignee: LifeNet Health
A61L27/3608A61F2/28A61L27/365A61L27/3834A61L27/502A61L27/56B28B1/007B28B17/02A61F2002/2817A61F2002/2828A61L2430/02B33Y80/00
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Quick Facts
Patent No.
US 11,576,999
App. No.
16/988,078
Granted
Feb 14, 2023
Kind
B2
Abstract

The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.

Claims (16)

1. A bone composition comprising bone fibers, wherein the bone fibers comprise microfibers having an average length (L) and an average width (W), wherein the average L:W ratio is greater than about 2.

2. The bone composition of claim 1 , wherein the average L:W ratio is greater than about 5.

3. The bone composition of claim 1 , wherein the average L:W ratio is greater than about 7.

4. The bone composition of claim 1 , wherein the average L:W ratio is in a range from 2 to 30.

5. The bone composition of claim 1 , wherein the average L:W ratio is in a range from 5 to 8.

6. The bone composition of claim 1 , wherein the W of the microfibers is less than about 2 μm.

7. The bone composition of claim 1 , wherein the W of the microfibers is less than about 1 μm.

8. The bone composition of claim 1 , wherein the L of the microfibers is less than about 12 μm.

9. The bone composition of claim 1 , wherein the L of the microfibers is less than about 7 μm.

10. The bone composition of claim 1 , wherein the bone composition is wet and the mode of the pore sizes of the wet bone composition is in a range from 25 to 250 μm.

11. The bone composition of claim 10 , wherein the mode of pore sizes of the wet bone composition at equilibrium does not have a bimodal distribution.

12. The bone composition of claim 1 , wherein when the bone composition is wet, the mean of the pore sizes of the wet bone composition is in a range from 20 to 100 μm.

13. The bone composition of claim 12 , wherein the mean of pore sizes of the wet bone composition at equilibrium is less than 30 μm or more than 65 μm.

14. The bone composition according to claim 1 , further comprising at least one cell and/or at least one bioactive factor.

15. The bone composition according to claim 1 , wherein the bone composition comprises bone particles having a median diameter of about 10-1,000 microns, a median length of about 0.5-100 mm, and a median thickness of about 10-1000 microns.

16. The bone composition of claim 1 , wherein the W of the microfibers is less than about 5 μm.

Assignments (2)
SECURITY INTEREST Recorded Apr 2, 2021
From: LIFENET HEALTH; SKIN AND WOUND ALLOGRAFT INSTITUTE, LLC
To: TRUIST BANK
Reel/Frame 055815/0623 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 10, 2020
From: CHEN, SILVIA; FRANCIS, MICHAEL; KEMPER, NATHAN; RODRIQUEZ, RUDY
To: LIFENET HEALTH
Reel/Frame 053443/0190 →