IP Library › Granted Patent US 12,396,961
Granted Patent B2
US 12,396,961 · App. 16/991,196 · Granted Aug 26, 2025

Compounds and compositions for intracellular delivery of agents

Inventors: Kerry E. Benenato (Sudbury, MA); William Butcher (Winthrop, MA)
Assignee: ModernaTX, Inc.
A61K9/5123A61K38/1808A61K38/1816A61K47/22A61K48/0058C07D211/14C07D211/16C07D241/04C07D295/13C07D295/185A61K9/127B82Y5/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 12,396,961
App. No.
16/991,196
Granted
Aug 26, 2025
Kind
B2
Abstract

The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

Claims (7)

1. A compound having the structure;

or a salt thereof.

2. A nanoparticle composition comprising a lipid component comprising a compound of claim 1 .

3. The nanoparticle composition of claim 2 , further comprising a therapeutic and/or prophylactic agent.

4. The nanoparticle composition of claim 3 , wherein the therapeutic and/or prophylactic agent comprises an mRNA.

5. A method of delivering a therapeutic and/or prophylactic agent to a mammalian cell or organ, the method comprising administering to a subject the nanoparticle composition of claim 3 , said administering comprising contacting the cell or organ with the nanoparticle composition, whereby the therapeutic and/or prophylactic agent is delivered to the cell.

6. A method of producing a polypeptide of interest in a mammalian cell, the method comprising contacting the cell with the nanoparticle composition of claim 3 , wherein the therapeutic and/or prophylactic agent is an mRNA, and wherein the mRNA encodes the polypeptide of interest, whereby the mRNA is capable of being translated in the cell to produce the polypeptide of interest.

Assignments (2)
SECURITY INTEREST Recorded Nov 19, 2025
From: MODERNATX, INC.
To: ARES CAPITAL CORPORATION, AS AGENT
Reel/Frame 073634/0354 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 12, 2020
From: BENENATO, KERRY E.; BUTCHER, WILLIAM
To: MODERNATX, INC.
Reel/Frame 053469/0879 →
Continuity (9)
Division 16065067
Provisional Application 62413345 · Oct 26, 2016
Provisional Application 62338474 · May 18, 2016
Provisional Application 62271160 · Dec 22, 2015
Provisional Application 62271137 · Dec 22, 2015
Provisional Application 62271200 · Dec 22, 2015
Provisional Application 62271146 · Dec 22, 2015
Provisional Application 62271179 · Dec 22, 2015
Related Publication 20210161829A1 · Jun 3, 2021
References Cited (400)
US 3324182A · De Brunner et al. · 1967 [cited by applicant]
US 3799876A · White et al. · 1974 [cited by examiner]
US 3872171A · Cronin et al. · 1975 [cited by applicant]
US 4125544A · Dygos · 1978 [cited by applicant]
US 4957735A · Huang · 1990 [cited by applicant]
US 5807861A · Klein et al. · 1998 [cited by applicant]
US 6143276A · Unger · 2000 [cited by applicant]
US 6303378B1 · Bridenbaugh et al. · 2001 [cited by applicant]
US 6395253B2 · Levy et al. · 2002 [cited by applicant]
US 6652886B2 · Ahn et al. · 2003 [cited by applicant]
US 6696038B1 · Mahato et al. · 2004 [cited by applicant]
US 7268120B1 · Horton et al. · 2007 [cited by applicant]
US 7371404B2 · Panzner et al. · 2008 [cited by applicant]
US 7943168B2 · Schlesinger et al. · 2011 [cited by applicant]
US 8058069B2 · Yaworski et al. · 2011 [cited by applicant]
US 8158601B2 · Chen et al. · 2012 [cited by applicant]
US 8420123B2 · Troiano et al. · 2013 [cited by applicant]
US 8440614B2 · Castor · 2013 [cited by applicant]
US 8449916B1 · Bellaire et al. · 2013 [cited by applicant]
US 8450298B2 · Mahon et al. · 2013 [cited by applicant]
US 8460696B2 · Slobodkin et al. · 2013 [cited by applicant]
US 8460709B2 · Ausborn et al. · 2013 [cited by applicant]
US 8563041B2 · Grayson et al. · 2013 [cited by applicant]
US 8568784B2 · Lillard et al. · 2013 [cited by applicant]
US 8569256B2 · Heyes et al. · 2013 [cited by applicant]
US 8580297B2 · Essler et al. · 2013 [cited by applicant]
US 8603499B2 · Zale et al. · 2013 [cited by applicant]
US 8603500B2 · Zale et al. · 2013 [cited by applicant]
US 8603501B2 · Zale et al. · 2013 [cited by applicant]
US 8603534B2 · Zale et al. · 2013 [cited by applicant]
US 8603535B2 · Troiano et al. · 2013 [cited by applicant]
US 8609142B2 · Troiano et al. · 2013 [cited by applicant]
US 8613951B2 · Zale et al. · 2013 [cited by applicant]
US 8613954B2 · Zale et al. · 2013 [cited by applicant]
US 8617608B2 · Zale et al. · 2013 [cited by applicant]
US 8618240B2 · Podobinski et al. · 2013 [cited by applicant]
US 8637083B2 · Troiano et al. · 2014 [cited by applicant]
US 8642076B2 · Manoharan et al. · 2014 [cited by applicant]
US 8652487B2 · Maldonado · 2014 [cited by applicant]
US 8652528B2 · Troiano et al. · 2014 [cited by applicant]
US 8663599B1 · Sung et al. · 2014 [cited by applicant]
US 8663700B2 · Troiano et al. · 2014 [cited by applicant]
US 8668926B1 · Mousa et al. · 2014 [cited by applicant]
US 8685368B2 · Reineke · 2014 [cited by applicant]
US 8691750B2 · Constien et al. · 2014 [cited by applicant]
US 8697098B2 · Perumal et al. · 2014 [cited by applicant]
US 8703204B2 · Bloom et al. · 2014 [cited by applicant]
US 8709483B2 · Farokhzad et al. · 2014 [cited by applicant]
US 8715736B2 · Sachdeva et al. · 2014 [cited by applicant]
US 8715741B2 · Maitra et al. · 2014 [cited by applicant]
US 8728527B2 · Singh · 2014 [cited by applicant]
US 8734832B2 · O'Hagan et al. · 2014 [cited by applicant]
US 8734846B2 · Ali et al. · 2014 [cited by applicant]
US 8734853B2 · Sood et al. · 2014 [cited by applicant]
US 8802644B2 · Chen et al. · 2014 [cited by applicant]
US 9006487B2 · Anderson et al. · 2015 [cited by applicant]
US 9029590B2 · Colletti et al. · 2015 [cited by applicant]
US 9394234B2 · Chen et al. · 2016 [cited by applicant]
US 9717690B2 · Guild et al. · 2017 [cited by applicant]
US 9738593B2 · Ansell et al. · 2017 [cited by applicant]
US 9867888B2 · Benenato · 2018 [cited by applicant]
US 9868691B2 · Benenato · 2018 [cited by applicant]
US 9868692B2 · Benenato · 2018 [cited by applicant]
US 9868693B2 · Benenato · 2018 [cited by applicant]
US 10106490B2 · Du · 2018 [cited by applicant]
US 10166298B2 · Ansell et al. · 2019 [cited by applicant]
US 10195156B2 · Benenato et al. · 2019 [cited by applicant]
US 10266485B2 · Benenato · 2019 [cited by applicant]
US 10392341B2 · Benenato et al. · 2019 [cited by applicant]
US 10442756B2 · Benenato et al. · 2019 [cited by applicant]
US 10799463B2 · Benenato et al. · 2020 [cited by applicant]
US 10857105B2 · Benenato et al. · 2020 [cited by applicant]
US 11001861B2 · Martini et al. · 2021 [cited by applicant]
US 11066355B2 · Benenato et al. · 2021 [cited by applicant]
US 11203569B2 · Almarsson et al. · 2021 [cited by applicant]
US 11220476B2 · Benenato et al. · 2022 [cited by applicant]
US 11504337B2 · Martini et al. · 2022 [cited by applicant]
US 11583504B2 · Brader · 2023 [cited by applicant]
US 11597698B2 · Benenato et al. · 2023 [cited by applicant]
US 11969506B2 · Patel et al. · 2024 [cited by applicant]
US 12077501B2 · Benenato et al. · 2024 [cited by applicant]
US 12144895B2 · Brader · 2024 [cited by applicant]
US 12151995B2 · Benenato · 2024 [cited by applicant]
US 20030073619A1 · Mahato et al. · 2003 [cited by applicant]
US 20030092653A1 · Kisich et al. · 2003 [cited by applicant]
US 20040142474A1 · Mahato et al. · 2004 [cited by applicant]
US 20050222064A1 · Vargeese et al. · 2005 [cited by applicant]
US 20060008910A1 · MacLachlan et al. · 2006 [cited by applicant]
US 20060083780A1 · Heyes et al. · 2006 [cited by applicant]
US 20060172003A1 · Meers et al. · 2006 [cited by applicant]
US 20060204566A1 · Smyth-Templeton et al. · 2006 [cited by applicant]
US 20070252295A1 · Panzner et al. · 2007 [cited by applicant]
US 20090042825A1 · Matar et al. · 2009 [cited by applicant]
US 20090042829A1 · Matar et al. · 2009 [cited by applicant]
US 20100285112A1 · Novobrantseva et al. · 2010 [cited by applicant]
US 20100324120A1 · Chen et al. · 2010 [cited by applicant]
US 20110009641A1 · Anderson et al. · 2011 [cited by applicant]
US 20110200582A1 · Baryza et al. · 2011 [cited by applicant]
US 20110244026A1 · Guild et al. · 2011 [cited by applicant]
US 20120136073A1 · Yang et al. · 2012 [cited by applicant]
US 20120177724A1 · Irvine et al. · 2012 [cited by applicant]
US 20120178702A1 · Huang et al. · 2012 [cited by applicant]
US 20120226085A1 · Ishihara et al. · 2012 [cited by applicant]
US 20120295832A1 · Constien et al. · 2012 [cited by applicant]
US 20130017223A1 · Hope et al. · 2013 [cited by applicant]
US 20130064894A1 · Martin et al. · 2013 [cited by applicant]
US 20130065942A1 · Matar et al. · 2013 [cited by applicant]
US 20130090372A1 · Budzik et al. · 2013 [cited by applicant]
US 20130108685A1 · Kuboyama et al. · 2013 [cited by applicant]
US 20130115273A1 · Yang et al. · 2013 [cited by applicant]
US 20130115274A1 · Knopov et al. · 2013 [cited by applicant]
US 20130116307A1 · Heyes et al. · 2013 [cited by applicant]
US 20130122104A1 · Yaworski et al. · 2013 [cited by applicant]
US 20130123338A1 · Heyes et al. · 2013 [cited by applicant]
US 20130129785A1 · Manoharan et al. · 2013 [cited by applicant]
US 20130130348A1 · Gu et al. · 2013 [cited by applicant]
US 20130142868A1 · Hoekman et al. · 2013 [cited by applicant]
US 20130142876A1 · Howard et al. · 2013 [cited by applicant]
US 20130150625A1 · Budzik et al. · 2013 [cited by applicant]
US 20130156845A1 · Manoharan et al. · 2013 [cited by applicant]
US 20130156849A1 · De Fougerolles et al. · 2013 [cited by applicant]
US 20130164400A1 · Knopov et al. · 2013 [cited by applicant]
US 20130171241A1 · Geall · 2013 [cited by applicant]
US 20130172406A1 · Zale et al. · 2013 [cited by applicant]
US 20130178541A1 · Stanton et al. · 2013 [cited by applicant]
US 20130183244A1 · Hanes et al. · 2013 [cited by applicant]
US 20130183355A1 · Jain et al. · 2013 [cited by applicant]
US 20130183372A1 · Schutt et al. · 2013 [cited by applicant]
US 20130183373A1 · Schutt et al. · 2013 [cited by applicant]
US 20130183375A1 · Schutt et al. · 2013 [cited by applicant]
US 20130189351A1 · Geall · 2013 [cited by applicant]
US 20130195759A1 · Mirkin et al. · 2013 [cited by applicant]
US 20130195765A1 · Gho et al. · 2013 [cited by applicant]
US 20130195967A1 · Guild et al. · 2013 [cited by applicant]
US 20130195968A1 · Geall et al. · 2013 [cited by applicant]
US 20130195969A1 · Geall et al. · 2013 [cited by applicant]
US 20130202684A1 · Geall et al. · 2013 [cited by applicant]
US 20130236500A1 · Zale et al. · 2013 [cited by applicant]
US 20130236533A1 · Von Andrian et al. · 2013 [cited by applicant]
US 20130236550A1 · Ausborn et al. · 2013 [cited by applicant]
US 20130243827A1 · Troiano et al. · 2013 [cited by applicant]
US 20130243848A1 · Lobovkina et al. · 2013 [cited by applicant]
US 20130243867A1 · Mohapatra et al. · 2013 [cited by applicant]
US 20130251766A1 · Zale et al. · 2013 [cited by applicant]
US 20130251816A1 · Zale et al. · 2013 [cited by applicant]
US 20130251817A1 · Zale et al. · 2013 [cited by applicant]
US 20130266617A1 · Mirosevich et al. · 2013 [cited by applicant]
US 20130273117A1 · Podobinski et al. · 2013 [cited by applicant]
US 20130274504A1 · Colletti et al. · 2013 [cited by applicant]
US 20130274523A1 · Bawiec, III et al. · 2013 [cited by applicant]
US 20130280334A1 · Karp et al. · 2013 [cited by applicant]
US 20130280339A1 · Zale et al. · 2013 [cited by applicant]
US 20130295183A1 · Troiano et al. · 2013 [cited by applicant]
US 20130295191A1 · Troiano et al. · 2013 [cited by applicant]
US 20130302432A1 · Zale et al. · 2013 [cited by applicant]
US 20130302433A1 · Troiano et al. · 2013 [cited by applicant]
US 20130315831A1 · Shi et al. · 2013 [cited by applicant]
US 20130330401A1 · Payne et al. · 2013 [cited by applicant]
US 20130338210A1 · Manoharan et al. · 2013 [cited by applicant]
US 20130344158A1 · Zale et al. · 2013 [cited by applicant]
US 20140017327A1 · Cheng et al. · 2014 [cited by applicant]
US 20140017329A1 · Mousa · 2014 [cited by applicant]
US 20140037573A1 · Eliasof et al. · 2014 [cited by applicant]
US 20140037660A1 · Fotin-Mleczek et al. · 2014 [cited by applicant]
US 20140037714A1 · Quay et al. · 2014 [cited by applicant]
US 20140039032A1 · Kuboyama et al. · 2014 [cited by applicant]
US 20140044772A1 · MacLachlan et al. · 2014 [cited by applicant]
US 20140044791A1 · Basilion et al. · 2014 [cited by applicant]
US 20140045913A1 · Kuboyama et al. · 2014 [cited by applicant]
US 20140050775A1 · Slobodkin et al. · 2014 [cited by applicant]
US 20140057109A1 · Menchen et al. · 2014 [cited by applicant]
US 20140065172A1 · Echeverri et al. · 2014 [cited by applicant]
US 20140065204A1 · Hayes et al. · 2014 [cited by applicant]
US 20140065228A1 · Yaworski et al. · 2014 [cited by applicant]
US 20140079774A1 · Brinker et al. · 2014 [cited by applicant]
US 20140093575A1 · Hammond et al. · 2014 [cited by applicant]
US 20140093579A1 · Zale et al. · 2014 [cited by applicant]
US 20140113137A1 · Podobinski et al. · 2014 [cited by applicant]
US 20140121263A1 · Fitzgerald et al. · 2014 [cited by applicant]
US 20140121393A1 · Manoharan et al. · 2014 [cited by applicant]
US 20140134260A1 · Heyes et al. · 2014 [cited by applicant]
US 20140141070A1 · Geall et al. · 2014 [cited by applicant]
US 20140141089A1 · Liang · 2014 [cited by applicant]
US 20140141483A1 · Bossard et al. · 2014 [cited by applicant]
US 20140142165A1 · Grayson et al. · 2014 [cited by applicant]
US 20140142254A1 · Fonnum et al. · 2014 [cited by applicant]
US 20140161830A1 · Anderson et al. · 2014 [cited by applicant]
US 20140288160A1 · Guild et al. · 2014 [cited by applicant]
US 20140308304A1 · Manoharan et al. · 2014 [cited by applicant]
US 20150174260A1 · Yang et al. · 2015 [cited by applicant]
US 20150174261A1 · Kuboyama et al. · 2015 [cited by applicant]
US 20150239926A1 · Payne et al. · 2015 [cited by applicant]
US 20150284317A1 · Colletti et al. · 2015 [cited by applicant]
US 20150343062A1 · Kuboyama et al. · 2015 [cited by applicant]
US 20150376115A1 · Ansell et al. · 2015 [cited by applicant]
US 20160002178A1 · Fenton et al. · 2016 [cited by applicant]
US 20160009657A1 · Anderson et al. · 2016 [cited by applicant]
US 20160022580A1 · Ramsay et al. · 2016 [cited by applicant]
US 20160151284A1 · Heyes et al. · 2016 [cited by applicant]
US 20160317458A1 · Brito et al. · 2016 [cited by applicant]
US 20160361411A1 · Gindy et al. · 2016 [cited by applicant]
US 20170119904A1 · Ansell et al. · 2017 [cited by applicant]
US 20180201572A1 · Benenato · 2018 [cited by applicant]
US 20180273467A1 · Benenato · 2018 [cited by applicant]
US 20180303925A1 · Weissman et al. · 2018 [cited by applicant]
US 20180333366A1 · Benenato et al. · 2018 [cited by applicant]
US 20180369419A1 · Benenato et al. · 2018 [cited by applicant]
US 20190016669A1 · Benenato et al. · 2019 [cited by applicant]
US 20190298657A1 · Martini et al. · 2019 [cited by applicant]
US 20190298658A1 · Benenato et al. · 2019 [cited by applicant]
US 20190314291A1 · Besin et al. · 2019 [cited by applicant]
US 20190314292A1 · Benenato et al. · 2019 [cited by applicant]
US 20190314524A1 · Ansell et al. · 2019 [cited by applicant]
US 20190336452A1 · Brader · 2019 [cited by applicant]
US 20190390181A1 · Benenato et al. · 2019 [cited by applicant]
US 20200069599A1 · Smith et al. · 2020 [cited by applicant]
US 20200129445A1 · Patel et al. · 2020 [cited by applicant]
US 20200131116A1 · Almarsson et al. · 2020 [cited by applicant]
US 20200306191A1 · Schariter et al. · 2020 [cited by applicant]
US 20210087135A1 · Benenato et al. · 2021 [cited by applicant]
US 20210154148A1 · Benenato et al. · 2021 [cited by applicant]
US 20210198200A1 · Benenato et al. · 2021 [cited by applicant]
US 20220073449A1 · Almarsson et al. · 2022 [cited by applicant]
US 20220106259A1 · Benenato et al. · 2022 [cited by applicant]
US 20220265857A1 · Besin et al. · 2022 [cited by applicant]
US 20220380299A1 · Benenato et al. · 2022 [cited by applicant]
US 20220409536A1 · Benenato et al. · 2022 [cited by applicant]
US 20230286903A1 · Benenato et al. · 2023 [cited by applicant]
US 20230364024A1 · Brader · 2023 [cited by applicant]
US 20240124388A1 · Benenato · 2024 [cited by applicant]
US 20240226026A1 · Benenato · 2024 [cited by applicant]
AU 652831B2 · 1994 [cited by applicant]
CN 102068701A · 2011 [cited by applicant]
CN 102204920A · 2011 [cited by applicant]
CN 102813929A · 2012 [cited by applicant]
CN 104644555A · 2015 [cited by applicant]
EP 0737750A2 · 1996 [cited by applicant]
EP 2073848B1 · 2013 [cited by applicant]
EP 1404860B1 · 2013 [cited by applicant]
EP 4488259A1 · 2025 [cited by applicant]
JP 2000169864A · 2000 [cited by applicant]
WO WO1993014778A1 · 1993 [cited by applicant]
WO WO9914346A2 · 1999 [cited by applicant]
WO WO9915580A1 · 1999 [cited by applicant]
WO WO9954344A1 · 1999 [cited by applicant]
WO WO1999052503A2 · 1999 [cited by applicant]
WO WO03086280A2 · 2003 [cited by applicant]
WO WO2005034979A2 · 2005 [cited by applicant]
WO WO2006063249A2 · 2006 [cited by applicant]
WO WO2008042973A2 · 2008 [cited by applicant]
WO WO2009024599A1 · 2009 [cited by applicant]
WO WO2009053686A1 · 2009 [cited by applicant]
WO WO2009086558A1 · 2009 [cited by applicant]
WO WO2009127060A1 · 2009 [cited by applicant]
WO WO2009129385A1 · 2009 [cited by applicant]
WO WO2009129395A1 · 2009 [cited by applicant]
WO WO2010030739A1 · 2010 [cited by applicant]
WO WO2010042877A1 · 2010 [cited by applicant]
WO WO2010053572A2 · 2010 [cited by applicant]
WO WO2010054406A1 · 2010 [cited by applicant]
WO WO2010060818A1 · 2010 [cited by applicant]
WO WO2010088537A2 · 2010 [cited by applicant]
WO WO2010129709A1 · 2010 [cited by applicant]
WO WO2010135207A1 · 2010 [cited by applicant]
WO WO2011017548A1 · 2011 [cited by applicant]
WO WO2011058990A1 · 2011 [cited by applicant]
WO WO2011068810A1 · 2011 [cited by applicant]
WO WO2011127255A1 · 2011 [cited by applicant]
WO WO2011136368A1 · 2011 [cited by applicant]
WO WO2012000104A1 · 2012 [cited by applicant]
WO WO2012006376A2 · 2012 [cited by applicant]
WO WO2012006378A1 · 2012 [cited by applicant]
WO WO2012030901A1 · 2012 [cited by applicant]
WO WO2012031043A1 · 2012 [cited by applicant]
WO WO2012031046A2 · 2012 [cited by applicant]
WO WO2012054365A2 · 2012 [cited by applicant]
WO WO2012129483A1 · 2012 [cited by applicant]
WO WO2012149252A2 · 2012 [cited by applicant]
WO WO2012149255A2 · 2012 [cited by applicant]
WO WO2012149265A2 · 2012 [cited by applicant]
WO WO2012149282A2 · 2012 [cited by applicant]
WO WO2012149301A2 · 2012 [cited by applicant]
WO WO2012149376A2 · 2012 [cited by applicant]
WO WO2012149393A2 · 2012 [cited by applicant]
WO WO2012153338A2 · 2012 [cited by applicant]
WO WO2012170889A1 · 2012 [cited by applicant]
WO WO2012170930A1 · 2012 [cited by applicant]
WO WO2013006825A1 · 2013 [cited by applicant]
WO WO2013006834A1 · 2013 [cited by applicant]
WO WO2013006837A1 · 2013 [cited by applicant]
WO WO2013006838A1 · 2013 [cited by applicant]
WO WO2013006842A2 · 2013 [cited by applicant]
WO WO2013016058A1 · 2013 [cited by applicant]
WO WO2013033438A2 · 2013 [cited by applicant]
WO WO2013033563A1 · 2013 [cited by applicant]
WO WO2013036835A1 · 2013 [cited by applicant]
WO WO2013049328A1 · 2013 [cited by applicant]
WO WO2013052167A2 · 2013 [cited by applicant]
WO WO2013056132A2 · 2013 [cited by applicant]
WO WO2013057715A1 · 2013 [cited by applicant]
WO WO2013059496A1 · 2013 [cited by applicant]
WO WO2013059922A1 · 2013 [cited by applicant]
WO WO2013064911A2 · 2013 [cited by applicant]
WO WO2013066903A1 · 2013 [cited by applicant]
WO WO2013067537A1 · 2013 [cited by applicant]
WO WO2013070872A1 · 2013 [cited by applicant]
WO WO2013072929A2 · 2013 [cited by applicant]
WO WO2013086322A1 · 2013 [cited by applicant]
WO WO2013086354A1 · 2013 [cited by applicant]
WO WO2013086373A1 · 2013 [cited by applicant]
WO WO2013086526A1 · 2013 [cited by applicant]
WO WO2013087083A1 · 2013 [cited by applicant]
WO WO2013087791A1 · 2013 [cited by applicant]
WO WO2013093648A2 · 2013 [cited by applicant]
WO WO2013126803A1 · 2013 [cited by applicant]
WO WO2013135359A1 · 2013 [cited by applicant]
WO WO2013143555A1 · 2013 [cited by applicant]
WO WO2013143683A1 · 2013 [cited by applicant]
WO WO2013148186A1 · 2013 [cited by applicant]
WO WO2013148541A1 · 2013 [cited by applicant]
WO WO2013149141A1 · 2013 [cited by applicant]
WO WO2013151650A1 · 2013 [cited by applicant]
WO WO2013155487A1 · 2013 [cited by applicant]
WO WO2013158127A1 · 2013 [cited by applicant]
WO WO2013158579A1 · 2013 [cited by applicant]
WO WO2013155493A9 · 2013 [cited by applicant]
WO WO2013166498A1 · 2013 [cited by applicant]
WO WO2013173693A1 · 2013 [cited by applicant]
WO WO2013177419A2 · 2013 [cited by applicant]
WO WO2013177421A2 · 2013 [cited by applicant]
WO WO2013185069A1 · 2013 [cited by applicant]
WO WO2014007398A1 · 2014 [cited by applicant]
WO WO2014008334A1 · 2014 [cited by applicant]
WO WO2014026284A1 · 2014 [cited by applicant]
WO WO2014028487A1 · 2014 [cited by applicant]
WO WO2014028763A1 · 2014 [cited by applicant]
WO WO2014047649A1 · 2014 [cited by applicant]
WO WO2014048969A1 · 2014 [cited by applicant]
WO WO2014052634A1 · 2014 [cited by applicant]
WO WO2014054026A1 · 2014 [cited by applicant]
WO WO2014071072A2 · 2014 [cited by applicant]
WO WO2014072997A1 · 2014 [cited by applicant]
WO WO2014089486A1 · 2014 [cited by applicant]
WO WO2014144196A1 · 2014 [cited by applicant]
WO WO2014160243A1 · 2014 [cited by applicant]
WO WO2014172045A1 · 2014 [cited by applicant]
WO WO2014182661A2 · 2014 [cited by applicant]
WO WO2014210356A1 · 2014 [cited by applicant]
WO WO2015011633A1 · 2015 [cited by applicant]
WO WO2015095346A1 · 2015 [cited by applicant]
WO WO2015130584A2 · 2015 [cited by applicant]
WO WO2015154002A1 · 2015 [cited by applicant]
WO WO2015199952A1 · 2015 [cited by applicant]
WO WO2016004202A1 · 2016 [cited by applicant]
WO WO2016004318A1 · 2016 [cited by applicant]
WO WO2016118697A1 · 2016 [cited by applicant]
WO WO2016118724A1 · 2016 [cited by applicant]
WO WO2016176330A1 · 2016 [cited by applicant]
WO WO2017010573A1 · 2017 [cited by examiner]
WO WO2017004143A1 · 2017 [cited by applicant]
WO WO2017015630A2 · 2017 [cited by applicant]
WO WO2017031232A1 · 2017 [cited by applicant]
WO WO2017049245A2 · 2017 [cited by applicant]
WO WO2017070616A2 · 2017 [cited by applicant]
WO WO2017070626A2 · 2017 [cited by applicant]
WO WO2017075531A1 · 2017 [cited by applicant]
WO WO2017099823A1 · 2017 [cited by applicant]
WO WO2017100744A1 · 2017 [cited by applicant]
WO WO2017117528A1 · 2017 [cited by applicant]
WO WO2017127750A1 · 2017 [cited by applicant]
WO WO2017176974A1 · 2017 [cited by applicant]
WO WO2017180917A2 · 2017 [cited by applicant]
WO WO2017192470A1 · 2017 [cited by applicant]
WO WO2017201317A1 · 2017 [cited by applicant]
WO WO2017201325A1 · 2017 [cited by applicant]
WO WO2017201328A1 · 2017 [cited by applicant]
WO WO2017201332A1 · 2017 [cited by applicant]
WO WO2017201333A1 · 2017 [cited by applicant]
WO WO2017201340A2 · 2017 [cited by applicant]
WO WO2017201342A1 · 2017 [cited by applicant]
WO WO2017201346A1 · 2017 [cited by applicant]
WO WO2017201347A1 · 2017 [cited by applicant]
WO WO2017201348A1 · 2017 [cited by applicant]
WO WO2017201349A1 · 2017 [cited by applicant]
WO WO2017201350A1 · 2017 [cited by applicant]
WO WO2017201352A1 · 2017 [cited by applicant]
WO WO2017218704A1 · 2017 [cited by applicant]
WO WO2018078053A1 · 2018 [cited by applicant]
WO WO2018081480A1 · 2018 [cited by applicant]
WO WO2018081638A1 · 2018 [cited by applicant]
WO WO2018089540A1 · 2018 [cited by applicant]
WO WO2018144775A1 · 2018 [cited by applicant]
WO WO2018170260A1 · 2018 [cited by applicant]
WO WO2018170270A1 · 2018 [cited by applicant]
WO WO2018170306A1 · 2018 [cited by applicant]
WO WO2018170322A1 · 2018 [cited by applicant]
WO WO2018170336A1 · 2018 [cited by applicant]
WO WO2018191719A1 · 2018 [cited by applicant]
WO WO2018200943A1 · 2018 [cited by applicant]
WO WO2018225871A1 · 2018 [cited by applicant]