IP Library Granted Patent US 11,026,798
Granted Patent B1
US 11,026,798 · App. 16/991,638 · Granted Jun 8, 2021

Sheet based triply periodic minimal surface implants for promoting osseointegration and methods for producing same

Inventors: Andrew Todd Miller (Durham, NC); Matthew Rexrode (Durham, NC); Cambre Kelly (Durham, NC); Ken Gall (Durham, NC)
Assignee: RESTOR3D, INC.
A61F2/3094A61F2/4455A61F2002/30736A61F2002/30784A61F2002/30985A61F2310/00023
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Quick Facts
Patent No.
US 11,026,798
App. No.
16/991,638
Granted
Jun 8, 2021
Kind
B1
Abstract

Provided herein are implants and methods for producing implants. In at least one embodiment, the implants include sheet-based, triply periodic, minimal surface (TPMS) portions. According to one embodiment, the TPMS portions include a gyroid architecture that provides for improved osseointegration and mechanical performance over previous implants due to novel ratios of porosity to compressive strength, among other features. In one or more embodiments, the gyroid architecture is organized into unit cells that demonstrate anisotropic mechanical performance along an insertion direction. In various embodiments, the present methods include novel selective laser melting (SLM) techniques for forming the TPMS portions of implants in a manner that reduces defect formation, thereby improving compressive performance and other implant properties.

Claims (43)

1. A 3D-printed implant comprising:

a top surface and a bottom surface;

a titanium frame comprising:

an interior portion, wherein the interior portion defines a void area; and

a titanium sheet-based triply periodic minimal surface (TPMS) portion integrally formed with the titanium frame via SLM 3D printing extending from the top surface through the void area of the titanium frame to the bottom surface, the TPMS portion comprising:

a wall density greater than 99%;

a stiffness modulus of about 3-14 GPa;

a porosity of about 55-85%; and

an ultimate compression strength of about 50-230 MPa.

2. The 3D-printed implant of claim 1 , wherein the TPMS portion is free of nodes.

3. The 3D-printed implant of claim 1 , further comprising one or more teeth extending from the top surface or bottom surface.

4. The 3D-printed implant of claim 3 , wherein the one or more teeth extend from the top or bottom surface along a surface of the titanium frame.

5. The 3D-printed implant of claim 1 , wherein the interior portion defines a second void area free of TPMS structures.

6. The 3D-printed implant of claim 1 , wherein:

the TPMS portion comprises a wall thickness of about 0.25 mm;

the stiffness modulus is about 3 GPa;

the porosity is about 85%; and

the ultimate compression strength is about 50 MPa.

7. The 3D-printed implant of claim 1 , wherein:

the TPMS portion comprises a wall thickness of about 1.00 mm;

the stiffness modulus is about 14 GPa;

the porosity is about 55%; and

the ultimate compression strength is about 227 MPa.

8. The 3D-printed implant of claim 1 , wherein the 3D-printed implant is anisotropic in an insertion direction.

9. The 3D-printed implant of claim 1 , wherein the 3D-printed implant is a spinal cage.

10. The 3D-printed implant of claim 1 , wherein the 3D-printed implant is an osteotomy wedge.

11. The 3D-printed implant of claim 1 , wherein the TPMS portion comprises a gyroid architecture.

12. A 3D-printed implant comprising:

a top surface and a bottom surface;

at least one titanium sheet based triply periodic minimal surface (TPMS) portion extending from the top surface to the bottom surface and comprising:

a wall density greater than 99%;

a stiffness modulus of about 3-14 GPa;

a porosity of about 55-85%; and

an ultimate compression strength of about 50-230 MPa.

13. The 3D-printed implant of claim 12 , wherein:

the top surface and the bottom surface define an interior portion; and

the interior portion defines at least one void area.

14. The 3D-printed implant of claim 13 , wherein the at least one titanium TPMS portion comprises a gyroid architecture.

15. The 3D-printed implant of claim 14 , wherein the at least one titanium TPMS portion is free of nodes.

16. The 3D-printed implant of claim 15 , further comprising one or more teeth extending from the top surface or the bottom surface.

17. The 3D-printed implant of claim 16 , wherein the 3D-printed implant is anisotropic in an insertion direction.

18. The 3D-printed implant of claim 12 , wherein the 3D-printed implant is a spinal cage.

19. The 3D-printed implant of claim 12 , wherein the 3D-printed implant is an osteotomy wedge.

Assignments (5)
SECURITY INTEREST Recorded Jun 7, 2024
From: RESTOR3D, INC.; CONFORMIS, INC.; IMATX, INC.
To: TRINITY CAPITAL INC., AS ADMINISTRATIVE AGENT
Reel/Frame 067679/0713 →
RELEASE OF SECURITY INTEREST Recorded Jan 9, 2023
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: SEASPINE HOLDINGS CORPORATION; SEASPINE ORTHOPEDICS CORPORATION; SEASPINE, INC.; ISOTIS, INC.; SEASPINE SALES LLC; ISOTIS ORTHOBIOLOGICS, INC.; THEKEN SPINE, LLC; SEASPINE ORTHOPEDICS INTERMEDIATECO, INC.; 7D SURGICAL USA INC.
Reel/Frame 062336/0593 →
SECOND AMENDMENT TO PATENT SECURITY AGREEMENT Recorded Jul 18, 2022
From: SEASPINE HOLDINGS CORPORATION; SEASPINE ORTHOPEDICS CORPORATION; SEASPINE, INC.; ISOTIS, INC.; SEASPINE SALES LLC; ISOTIS ORTHOBIOLOGICS, INC.; THEKEN SPINE, LLC; SEASPINE ORTHOPEDICS INTERMEDIATECO, INC.; 7D SURGICAL USA INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS AGENT
Reel/Frame 060715/0395 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2021
From: GALL, KEN; KELLY, CAMBRE
To: DUKE UNIVERSITY
Reel/Frame 056231/0343 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2020
From: MILLER, ANDREW TODD; REXRODE, MATTHEW
To: RESTOR3D, INC.
Reel/Frame 054006/0300 →
Cited By (12)
US 1,107,916 US 1,122,446 US 1,124,342 US 1,130,740 US 1,130,746 US 1,132,447 US 12,582,527 US 12,599,390 US 12,648,860 US 12,653,680 US 12,667,461 US 12,690,986