Tableted cannabinoid chewing gum with layered structure

1. A pressed chewing gum tablet comprising a plurality of particles, including a first population of particles comprising water-insoluble gum base and a second population of particles comprising water-soluble chewing gum ingredients, and the pressed chewing gum tablet constituting at least two layers, wherein

a) a first layer of the pressed gum tablet comprises water-insoluble gum base and

b) a second layer of the pressed chewing gum tablet, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, and wherein the pressed chewing gum tablet comprises one or more cannabinoids.

2. The pressed chewing gum tablet according to claim 1 , wherein the pressed shewing gum tablet consists of two layers.

3. The pressed chewing gum tablet according to claim 1 , wherein the weight ratio of the first layer relative to the second layer is from 1:10 to 10:1.

4. The pressed chewing gum tablet according to claim 1 , wherein the weight ratio of the first layer relative to the second layer is from 1:2 to 2:1.

5. The pressed chewing gum tablet according to claim 1 , wherein the pressed chewing gum tablet consists of three layers where the first layer is the middle layer, and the second layer is cohered to and adjacent to one side of the first layer, and a third layer is cohered to and adjacent to the opposite side of the first layer.

6. The pressed chewing gum tablet according to claim 5 , wherein the weight ratio of the first layer relative to the second layer relative to the third layer is from 1:5:5 to 10:1:1.

7. The pressed chewing gum tablet according to claim 5 , wherein the weight ratio of the first layer relative to the second layer relative to the third layer is from 1:3:3 to 3:1:1.

8. The pressed chewing gum tablet according to claim 1 , wherein the pressed chewing gum tablet consists of three layers where the second layer is the middle layer, and the first layer is cohered to and adjacent to one side of the second layer, and a third layer is cohered to and adjacent to the opposite side of the second layer.

9. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is present in the first population of particles comprising water-insoluble gum base.

10. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is located in the first layer of the chewing gum composition.

11. The pressed chewing gum tablet according to claim 1 , wherein the content of water-insoluble gum base of the first layer is more than 30% by weight of the first layer.

12. The pressed chewing gum tablet according to claim 1 , wherein the content of water-soluble chewing gum ingredients of the second layer is more than 50% by weight of the second layer.

13. The pressed chewing gum tablet according to claim 1 , wherein the gum base comprising one or more natural resins in an amount of 10-40% by weight of the gum base, one or more elastomers in an amount of 3-30% by weight of the gum base, and one or more elastomer plasticizers in an amount of 8-50% by weight of the gum base.

14. The pressed chewing gum tablet according to claim 1 , wherein the water-soluble chewing gum ingredients comprise one or more sugar alcohols or one or more sugars in an amount of 35-80% by weight of the tablet.

15. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is present in a premixture with one or more sugar alcohols, one or more sugars or one or more microcrystalline species.

16. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids comprises at least one phytocannabinoid that is contained in a cannabinoid extract when incorporated in the tablet.

17. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids comprises at least two cannabinoids.

18. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of a phytocannabinoid, an endocannabinoid and a synthetic cannabinoid.

19. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids comprises palmitoylethanolamide.

20. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is located in a protein carrier.

21. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is part of a self-emulsifying drug delivery system.

22. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), salts and derivatives thereof.

23. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), salts and derivatives thereof.

24. The pressed chewing gum tablet according to claim 1 , wherein the one or more cannabinoids is selected from the group consisting of cannabichromene (CBC), cannabichromenic acid (CBCV), cannabigerol (CBG), cannabigerol propyl variant (CBGV), cannabicyclol (CBL), cannabinol (CBN), cannabinol propyl variant (CBNV), cannabitriol (CBO), and tetrahydrocannabivarinic acid (THCVA).

25. The pressed chewing gum tablet according to claim 1 , wherein the tablet comprises a further active ingredient different from the one or more cannabinoids.

26. A compressed chewing gum tablet, the tablet comprising a plurality of particles, and the tablet constituting at least two layers, wherein

a) a first layer of the tablet comprises water-insoluble gum base and

b) a second layer of the tablet, which is cohered to and adjacent to the first layer, comprises water-soluble chewing gum ingredients, the second layer being free of water-insoluble gum base, and

wherein the tablet comprises one or more cannabinoids.