IP Library Granted Patent US 11,225,479
Granted Patent B2
US 11,225,479 · App. 17/007,151 · Granted Jan 18, 2022

Bicyclic inhibitors of histone deacetylase

Inventors: Nathan Oliver Fuller (Arlington, MA); John A. Lowe, III (Stonington, CT)
Assignee: Alkermes, Inc.
C07D471/04A61K31/437A61K31/519A61P25/28C07D487/04
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Quick Facts
Patent No.
US 11,225,479
App. No.
17/007,151
Granted
Jan 18, 2022
Kind
B2
Abstract

Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with inhibition of HDAC (e.g., HDAC2).

Claims (8)

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

4. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

5. A method of inhibiting HDAC activity in a subject comprising the step of administering to the subject in need thereof an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt thereof, or the composition of claim 4 .

Assignments (5)
SECURITY INTEREST Recorded Feb 13, 2026
From: ALKERMES, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073790/0950 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (072656/0509) Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES, INC.
Reel/Frame 074858/0481 →
SECURITY INTEREST Recorded Oct 23, 2025
From: ALKERMES, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 072656/0509 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 15, 2021
From: FULLER, NATHAN OLIVER; LOWE, JOHN A., III
To: RODIN THERAPEUTICS, INC.
Reel/Frame 055934/0240 →
CHANGE OF NAME Recorded Dec 1, 2020
From: RODIN THERAPEUTICS, INC.
To: ALKERMES, INC.
Reel/Frame 054504/0354 →