IP Library › Granted Patent US 12,262,911
Granted Patent B2
US 12,262,911 · App. 17/011,448 · Granted Apr 1, 2025

Methods and systems for treatment of acute ischemic stroke

Inventors: Michi E. Garrison (San Mateo, CA); Tony M. Chou (San Mateo, CA)
Assignee: Route 92 Medical, Inc.
A61B17/3415A61B17/0218A61B17/22A61B17/221A61B17/3417A61M1/3621A61M1/82A61M25/0662A61M60/268A61M60/43A61B2017/22034A61B2017/22039A61B2017/22044A61B2017/22054A61B2017/22067A61B2017/22084A61B2017/2212A61B2017/2217A61B17/32037A61B2017/320733A61F2/013A61M2025/0681
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Quick Facts
Patent No.
US 12,262,911
App. No.
17/011,448
Granted
Apr 1, 2025
Kind
B2
Abstract

An arterial access device has an internal lumen and a proximal port, the arterial access device sized and shaped to be inserted directly into an arterial access site in the common carotid artery such that the lumen provides a passageway for an interventional device to be inserted via the proximal port into the carotid artery. The arterial access device has a distal portion that is configured to be inserted into an arterial pathway through the access site, and a proximal portion configured to extend outward from the access site when the distal portion is in the arterial pathway.

Claims (33)

1. A system of devices for performing a medical procedure at a treatment site in a cerebral vessel of a patient, the system comprising:

a catheter having a catheter lumen having an inner diameter and a distal end; and

an inner member sized and shaped to slide within the catheter lumen, wherein the inner member defines a single lumen and has a distal portion and a distal-most end, wherein the distal portion has a first outer diameter that decreases distally to a second outer diameter at the distal-most end that is smaller than the first outer diameter, and wherein the first outer diameter is sized so that, when the inner member is positioned in an advancement configuration relative to the catheter forming an assembled catheter system, the inner member extends through the catheter lumen and the distal portion is positioned distal to the distal end of the catheter to form a smooth transition from the second outer diameter to the inner diameter of the catheter lumen at the distal end of the catheter and minimizing a step at the distal end of the catheter, and

a guidewire positioned within the single lumen of the inner member and extending out a distal opening of the distal portion of the inner member, wherein when the assembled catheter system is positioned with the inner member in the advancement configuration and the guidewire extending out of the distal opening of the distal portion of the inner member, the distal portion of the inner member creates a smooth transition in flexibility between a flexibility of the guidewire to a flexibility of the distal end of the catheter, and

wherein the assembled catheter system is sufficiently flexible that, when positioned in the advancement configuration, the catheter and inner member are configured to be advanced together over the guidewire distal to a petrous portion of an internal carotid artery.

2. The system of claim 1 , wherein the inner diameter of the catheter lumen is 0.89 mm to 2.41 mm.

3. The system of claim 1 , wherein the outer diameter of the guidewire is 0.36 mm to 0.46 mm.

4. The system of claim 2 , wherein an inner diameter of the single lumen of the inner member is 0.51 mm to 0.61 mm.

5. The system of claim 1 , wherein the first outer diameter substantially corresponds to the inner diameter of the distal end of the catheter.

6. The system of claim 1 , wherein the inner member is constructed of a material at the distal portion that is softer than a material proximal to the distal portion.

7. The system of claim 1 , wherein the catheter further comprises a flexible distal luminal portion and a proximal tether element extending proximally from a point of attachment near a proximal end of the flexible distal luminal portion, the proximal tether element extending proximally to outside the body of the patient.

8. The system of claim 7 , wherein an outer diameter of the proximal tether element at the point of attachment is smaller than an outer diameter of the distal luminal portion at the point of attachment.

9. The system of claim 7 , wherein the proximal tether element is solid or has a lumen.

10. The system of claim 7 , further comprising an arterial access device comprising an elongate body sized and shaped to be introduced into a carotid artery, the elongate body defining an internal lumen and a distal end.

11. The system of claim 10 , wherein a length of the flexible distal luminal portion is less than an insertable length of the arterial access device.

12. The system of claim 10 , further comprising a hemostasis valve positioned on a proximal end region of the arterial access device, optionally wherein a negative pressure device is coupled to a suction port on the hemostasis valve, the negative pressure device comprising a pump.

13. The system of claim 12 , wherein the pump is configured to apply aspiration forces through the internal lumen of the catheter.

14. The system of claim 1 , wherein a flexibility of the distal portion decreases proximally from the second outer diameter of the inner member.

15. The system of claim 1 , wherein a length of the distal portion has a greater flexibility than the distal end of the catheter.

16. The system of claim 15 , wherein the distal portion of the inner member tapers distally from the first outer diameter to the second outer diameter.

17. The system of claim 1 , wherein when the assembled catheter system is positioned with the inner member in the advancement configuration and the guidewire extending out of the distal opening of the distal portion of the inner member, the distal portion of the inner member creates a smooth transition in diameter between an outer diameter of the guidewire to an inner diameter of the distal end of the catheter.

18. A system of devices for performing a medical procedure at a treatment site in a cerebral vessel of a patient, the system comprising:

a catheter having a catheter lumen having an inner diameter and a distal end; and

an inner member sized and shaped to slide within the catheter lumen, wherein the inner member defines a single lumen and has a distal portion and a distal-most end, wherein the distal portion has a first outer diameter that decreases distally to a second outer diameter at the distal-most end that is smaller than the first outer diameter, and wherein the first outer diameter is sized so that, when the inner member is positioned in an advancement configuration relative to the catheter forming an assembled catheter system, the inner member extends through the catheter lumen and the distal portion is positioned distal to the distal end of the catheter to minimize a step at the distal end of the catheter, and

a guidewire positioned within the single lumen of the inner member and extending out a distal opening of the distal portion of the inner member, wherein when the assembled catheter system is positioned with the inner member in the advancement configuration and the guidewire extending out of the distal opening of the distal portion of the inner member, the distal portion of the inner member creates a smooth transition in flexibility between a flexibility of the guidewire to a flexibility of the distal end of the catheter, and

wherein the assembled catheter system is sufficiently flexible that, when positioned in the advancement configuration, the catheter and inner member are configured to be advanced together over the guidewire distal to a petrous portion of an internal carotid artery.

19. The system of claim 18 , wherein an outer diameter of the guidewire is 0.36 mm to 0.46 mm.

20. The system of claim 18 , wherein the inner diameter of the catheter lumen is 0.89 mm to 2.41 mm.

21. The system of claim 20 , wherein an inner diameter of the single lumen of the inner member is 0.51 mm to 0.61 mm.

22. The system of claim 18 , wherein the first outer diameter substantially corresponds to an inner diameter of the distal end of the catheter.

23. The system of claim 18 , wherein a flexibility of the distal portion decreases proximally from the second outer diameter of the inner member.

24. The system of claim 23 , wherein the distal portion of the inner member tapers distally from the first outer diameter to the second outer diameter.

25. The system of claim 18 , wherein when the assembled catheter system is positioned with the inner member in the advancement configuration and the guidewire extending out of the distal opening of the distal portion of the inner member, the distal portion of the inner member creates a smooth transition in diameter between an outer diameter of the guidewire to an inner diameter of the distal end of the catheter.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 4, 2025
From: CHOU, TONY M.
To: ROUTE 92 MEDICAL, INC.
Reel/Frame 070099/0258 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2021
From: GARRISON, MICHI E.
To: SILK ROAD MEDICAL, INC.
Reel/Frame 055890/0730 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2021
From: SILK ROAD MEDICAL, INC.
To: NEUROCO, INC.
Reel/Frame 055891/0463 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 12, 2021
From: NEUROCO, INC.
To: ROUTE 92 MEDICAL, INC.
Reel/Frame 055896/0608 →
Continuity (7)
Continuation 13921165 · Jun 18, 2013
Continuation In Part 13566451 · Aug 3, 2012
Provisional Application 61579581 · Dec 22, 2011
Provisional Application 61547597 · Oct 14, 2011
Provisional Application 61543019 · Oct 4, 2011
Provisional Application 61515736 · Aug 5, 2011
Related Publication 20210052296A1 · Feb 25, 2021
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