Use of the phytocannabinoid cannabidivarin (CBDV) in the treatment of epilepsy
This invention relates to the use of the phytocannabinoid cannabidivarin (CBDV) and combinations of the phytocannabinoid CBDV with tetrahydrocannabivarin (THCV) and cannabidiol (CBD) in the treatment of epilepsy. The invention further relates to the use of the phytocannabinoid CBDV in combination with standard anti-epileptic drugs (SAEDs). Preferably the SAED is one of ethosuximide, valproate or phenobarbital.
1. A method for the treatment of epileptic seizures, which comprises administering to a subject in need thereof a therapeutically effective amount of CBDV, wherein the CBDV is present in a cannabis plant extract that comprises a phytocannabinoid containing component and a non-phytocannabinoid containing component, wherein the phytocannabinoid containing component comprises greater than 50% (w/w) of the cannabis plant extract and contains as a principal phytocannabinoid, CBDV, in an amount greater than 40% (w/w) of the cannabis plant extract and as a secondary phytocannabinoid, CBD, in an amount greater than 5% (w/w) and no more than 27% (w/w) of the cannabis plant extract, and wherein the non-phytocannabinoid containing component comprises a monoterpene fraction present in greater than 50% w/w of the total terpene fraction and a sesquiterpene fraction present in greater than 25% w/w of the total terpene fraction.
2. The method of claim 1 , wherein the cannabis plant extract further comprises THCV.
3. The method of claim 1 , wherein the phytocannabinoid containing component comprises 64-78% (w/w) of the cannabis plant extract.
4. The method of claim 3 , wherein the phytocannabinoid containing component comprises 52-64% (w/w) CBDV of the total phytocannabinoid fraction.
5. The method of claim 4 , wherein the phytocannabinoid containing component comprises 22-27% (w/w) CBD.
6. The method of claim 4 , wherein the phytocannabinoid containing component comprises 3.9-4.7% (w/w) THCV.
7. The method of claim 1 , wherein the monoterpene fraction comprises a principle monoterpene in an amount in the range of 61-75% (w/w), and comprises a secondary monoterpene fraction in an amount in the range of 16.3-20% (w/w).