RIP1 inhibitory compounds and methods for making and using the same
Disclosed herein are kinase inhibitory compounds, such as a receptor-interacting protein-1 (RIP1) kinase inhibitor compounds, as well as pharmaceutical compositions and combinations comprising such inhibitory compounds. The disclosed compounds, pharmaceutical compositions, and/or combinations may be used to treat or prevent a kinase-associated disease or condition, particularly a RIP1-associated disease or condition.
1. A compound, having a formula
or a pharmaceutically acceptable salt thereof.
2. A compound, having a formula
or a pharmaceutically acceptable salt thereof.
3. The compound according to claim 1 which is:
4. The compound according to claim 2 which is:
5. A pharmaceutical composition, comprising a compound having the formula:
or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
6. The pharmaceutical composition according to claim 5 wherein the compound is:
7. A pharmaceutical composition, comprising a compound having the formula:
or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
8. The pharmaceutical composition according to claim 7 wherein the compound is: