DRUG VEHICLE COMPOSITIONS AND METHODS OF USE THEREOF
The invention is directed to a topical lidocaine gel composition comprising lidocaine or a salt thereof, one or more nonionic surfactants, a polyethylene glycol, mannitol, magnesium chloride, sodium chloride and carboxymethyl cellulose. The invention is further directed to a method of inducing local anesthesia in an eye of a patient comprising topically applying compositions of the present invention to the eye of the patient.
1 . A topical ophthalmological lidocaine gel composition comprising:
from about 3% to about 4% w/v lidocaine hydrochloride;
one or more nonionic surfactants having a total concentration from about 2% to about 6% w/v;
from about 0.25% to about 2.5% w/v of a polyethylene glycol having a molecular weight of from about 400 to about 20,000 Daltons;
from about 0.25% to about 1.5% w/v mannitol;
from about 0.05% to about 0.2% w/v magnesium chloride;
from about 0.1% to about 1.25% w/v sodium chloride; and
from about 0.1% to about 2% w/v of a cellulose derivative,
wherein w/v denotes weight by total volume of the composition.
2 . The composition of claim 1 , wherein the one or more surfactants are selected from the group consisting of polysorbates, poloxamers, polyoxyl castor oils and cyclodextrins.
3 . The composition of claim 2 , wherein the one or more surfactants are selected from the group consisting of polysorbate 80, poloxamer 407, poloxamer 188, polyoxyl 35 castor oil and hydroxypropyl-gamma-cyclodextrin.
4 . The composition of claim 3 , wherein polysorbate 80 is at a concentration from about 0.5% to about 2.0% w/v.
5 . The composition of claim 3 , wherein poloxamer 407 is at a concentration from about 0.5% to about 1.5% w/v.
6 . The composition of claim 3 , wherein poloxamer 188 is at a concentration from about 0.1% to about 0.5% w/v.
7 . The composition of claim 3 , wherein polyoxyl 35 castor oil is at a concentration from about 0.1% to about 0.5% w/v.
8 . The composition of claim 3 , wherein hydroxypropyl-gamma-cyclodextrin is at a concentration from about 0.5% to about 1.5% w/v.
9 . The composition of claim 1 , wherein the polyethylene glycol is from about 0.25% to about 0.75% w/v polyethylene glycol 400.
10 . The composition of claim 1 , wherein mannitol is at a concentration from about 0.5% to about 1% w/v.
11 . The composition of claim 1 , wherein magnesium chloride is at a concentration from about 0.05% to about 0.15% w/v.
12 . The composition of claim 1 , wherein sodium chloride is at a concentration from about 0.2% to about 0.6% w/v.
13 . The composition of claim 1 , wherein the one or more cellulose derivatives are selected from the group consisting of sodium carboxymethyl cellulose, hydroxypropyl methylcellulose, hydroxypropyl cellulose.
14 . The composition of claim 13 , wherein the cellulose polymer is sodium carboxymethyl cellulose.
15 . The composition of claim 14 , wherein sodium carboxymethyl cellulose is at a concentration from about 0.5% to about 1.5% w/v.
16 . A method of inducing local anesthesia in an eye of a patient comprising topically applying the composition of claim 1 to the eye of the patient.
17 . A topical ophthalmological lidocaine gel composition comprising:
about 3.5% w/v lidocaine hydrochloride;
from about 0.5% to about 1.0% w/v polysorbate 80;
about 1.0% w/v poloxamer 407;
about 0.2% w/v poloxamer 188;
about 0.25% w/v polyoxyl 35 castor oil;
from about 0.5% to about 1.5% w/v hydroxypropyl-gamma-cyclodextrin;
about 0.5% w/v polyethylene glycol 400;
about 0.75% w/v mannitol;
about 0.1% w/v magnesium chloride;
about 0.4% w/v sodium chloride;
about 1.0% w/v sodium carboxymethyl cellulose; and
optionally, citrate buffer or phosphate buffer,
wherein w/v denotes weight by total volume of the composition.
18 . The composition of claim 17 , wherein the concentration of polysorbate 80 is about 1.0% w/v and the concentration of hydroxypropyl-gamma-cyclodextrin is about 1.5% w/v.
19 . A method of inducing local anesthesia in an eye of a patient comprising topically applying the composition of claim 18 to the eye of the patient.