Compositions for Preparing Regulatory T-Cell Compositions for the Treatment of Autoimmune Disease
The invention provides cell culture compositions for regulatory T-cells that include particular synthetic peptides. Also provided are methods of treating autoimmune diseases such as age-related macular degeneration and uveitis with regulatory T-cells prepared using said compositions.
1 . A composition, comprising:
synthetic peptide GEPIPVTVDVTNNTEKTVKK (SEQ ID NO:1); and
cell growth media capable of supporting human regulatory T-cells.
2 . The composition of claim 1 , consisting essentially of:
synthetic peptide GEPIPVTVDVTNNTEKTVKK (SEQ ID NO:1); and
cell growth media capable of supporting human regulatory T-cells.
3 . A composition, comprising:
synthetic peptide GEPIPVTVDVTNNTEKTVKK (SEQ ID NO:1); and
cell growth media capable of supporting human regulatory T-cells selected from the group consisting of CD4+CD25+ T cells, CD4+Foxp3+ T-cells, and CD4+CD25+Foxp3+ T-cells.
4 . The composition of claim 3 , consisting essentially of:
synthetic peptide GEPIPVTVDVTNNTEKTVKK (SEQ ID NO:1); and
cell growth media capable of supporting human regulatory T-cells selected from the group consisting of CD4+CD25+ T cells, CD4+Foxp3+ T-cells, and CD4+CD25+Foxp3+ T-cells.