Method for preparing particles comprising metal oxide coating and particles with metal oxide coating
The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer. The invention further relates to particles comprising a particulate matter coated by a metal oxide layer, to a use of the particles for topical administration, and to a method for preventing, reducing, or eliminating pests at a locus, using the particles.
1. Particles comprising a solid benzoyl peroxide core encapsulated by a metal oxide coating; wherein
the weight ratio of the metal oxide coating to said benzoyl peroxide is in the range of 1:99 to 40:60;
the dissolution rate of 50% w/w of the benzoyl peroxide from the encapsulated particle is at least two-fold longer than the dissolution rate of benzoyl peroxide from a non-encapsulated particle having the same particle diameter under identical conditions; and
said metal oxide coating has 5-102 layers and a total thickness of 0.3-10 microns;
wherein said particles are obtained after a step of aging at a temperature of 4° C.-90° C. and at a pH of 3-9.
2. Particles comprising a solid benzoyl peroxide core encapsulated by a metal oxide coating, wherein the metal oxide coating has 5-102 layers; wherein the particles are prepared by the following steps:
a) Contacting, in an aqueous medium, solid benzoyl peroxide with a cationic surfactant additive to obtain a dispersion of said solid benzoyl peroxide having positive charges on its surface;
b) adding an aqueous solution of a metal oxide salt to said dispersion, wherein said metal oxide salt precipitates onto the benzoyl peroxide, and acidifying the mixture to form a solid benzoyl peroxide coated with a metal oxide layer;
b1) contacting said solid benzoyl peroxide coated with a metal oxide layer of the preceding step within the mixture with a surface adhering additive being one or both of (i) a cationic polymer additive or (ii) a non-ionic additive, to obtain a dispersion of said coated solid benzoyl peroxide having an adhering additive on the surface thereof;
b2) bringing the dispersion obtained in step (b1) into contact with an aqueous solution of a metal oxide salt, under conditions wherein said metal oxide salt precipitates onto the surface of said coated solid benzoyl peroxide, and acidifying the obtained mixture to form a solid benzoyl peroxide that has an additional metal oxide layer coated thereon;
c) repeating steps (b1) and (b2) 3-100 more times; and
d) after completion of step (c), aging the metal oxide layers to form a coated, solid benzoyl peroxide having a coating thickness in the range of 0.3-10 microns; wherein the coated, solid benzoyl peroxide has a weight ratio of the metal oxide to benzoyl peroxide of 1:99 to 40:60, wherein said aging is not conducted between repeated coating steps, but only at the end of the process, and
wherein said aging is conducted at a temperature of 4° C.-90° C. and at a pH of 3-9.
3. A composition comprising the benzoyl peroxide particles according to claim 1 , and a pharmaceutically acceptable carrier.
4. A composition comprising benzoyl peroxide particles according to claim 2 , and a pharmaceutically acceptable carrier.