Heterocyclic compounds for the treatment of neurological and psychological disorders
Lactam compounds of Formula I and their use for the treatment of neurological and psychiatric disorders including schizophrenia, bipolar disorder, anxiety disorder and insomnia is disclosed.
1. A process for the synthesis of a compound of Formula XXIV:
comprising the step of reacting a compound of Formula XXIII:
with paraformaldehyde;
wherein
represents a single or double bond;
Semicircle represents phenyl;
A is absent;
Cy 1 is heterocyclyl;
B is C 1 -C 10 alkyl;
D is —O—;
each G 1 and G 2 is —[C(R 10 )(R 11 )] t —;
t is 1;
R 10 and R 11 is independently absent, hydrogen, or halogen;
R 1 is optionally substituted aryl;
m and q are 0; and
R 101 and R 103 are hydrogen;
wherein a compound of Formula XXIV is formed.
2. The process according to claim 1 further comprising the step of reacting said compound of Formula XXIII with an acid anhydride.
3. The process according to claim 2 , wherein said acid anhydride is hexanoic anhydride or lauric anhydride.
4. The process according to claim 1 , wherein R 1 is
5. The process according to claim 1 , wherein Cy 1 is
6. The process according to claim 1 , wherein the compound of Formula XXIV is
and the compound of Formula XXIII is arioiorazole:
7. The process according to claim 2 , wherein the step of reacting said compound of Formula XXIII with an acid anhydride produces a compound of Formula
8. The process according to claim 1 , wherein the reaction is performed in triethylamine and dimethylformamide.
9. The process according to claim 1 , wherein the reaction is performed at 80° C.
10. The process according to claim 2 , wherein the reaction is performed in anhydrous tetrahydrofuran (THF).
11. The process according to claim 2 , wherein the reaction is performed at 60° C.
12. The process according to claim 2 , wherein triethylamine is added to the reaction.