Intra-aneurysm devices
Devices for occluding an aneurysm are provided. In particular, the device include an upper member that sits against the dome of the aneurysm, a lower member that sits in the neck of the aneurysm, and a means of adjusting the overall dimensions of the device. Also provided are methods of making and using these devices.
1. A vaso-occlusive device for placement within an aneurysm having a neck and a sac and capable of functioning as a vaso-occlusive device by itself, the vaso-occlusive device comprising:
a plurality of inter-woven wires having a compressed delivery configuration for passage through a delivery catheter, and an expanded deployed configuration,
wherein, when the vaso-occlusive device is positioned within the aneurysm in the expanded deployed configuration, the plurality of inter-woven wires are configured to bridge and cover the neck of the aneurysm and alone cause formation of an embolus to occlude the sac,
wherein, in the expanded deployed configuration, the plurality of inter-woven wires form an external concavity in a first end portion of the vaso-occlusive device, an external concavity in a second end portion of the vaso-occlusive device, and a contiguous middle body portion between the first end portion and the second end portion, and
wherein an entirety of the contiguous middle body portion, between the first end portion and the second end portion, is expandable when the plurality of inter-woven wires are deployed from the compressed delivery configuration to the expanded deployed configuration.
2. The vaso-occlusive device of claim 1 , wherein in the expanded deployed configuration, the contiguous middle body portion defines a cylindrical shape having a first end that transitions into the first end portion, and a second end that transitions into the second end portion.
3. The vaso-occlusive device of claim 1 , wherein the contiguous middle body portion is self-expanding.
4. The vaso-occlusive device of claim 1 , further comprising a detachment junction that is configured to detach the vaso-occlusive device from the delivery catheter responsive to at least one stimulus selected from a group consisting of: a mechanical stimulus, an electrolytic stimulus, and a thermal stimulus.
5. The vaso-occlusive device of claim 4 , wherein the detachment junction is disposed between the plurality of inter-woven wires and a pusher wire slidably disposed within the delivery catheter.
6. The vaso-occlusive device of claim 1 , wherein the vaso-occlusive device is made from a biocompatible material.
7. The vaso-occlusive device of claim 1 , further comprising a bioactive agent.
8. The vaso-occlusive device of claim 1 , wherein, when the vaso-occlusive device is positioned within the aneurysm in the expanded deployed configuration, the vaso-occlusive device is configured to press against the sac of the aneurysm while the first end portion bridges and covers the neck of the aneurysm, and
wherein the aneurysm is a wide neck aneurysm in which the neck has a diameter that is at least 80 percent of a largest diameter of the aneurysm.
9. A vaso-occlusive assembly, comprising:
a delivery catheter;
an elongated pusher member at least partially slidably disposed within the delivery catheter; and
a vaso-occlusive device coupled to a distal end of the elongated pusher member,
wherein the vaso-occlusive device is configured for implantation in an aneurysm and is capable of functioning as a vaso-occlusive device by itself,
wherein the vaso-occlusive device has a compressed delivery configuration when restrained within the delivery catheter, and an expanded deployed configuration after being released from the delivery catheter into the aneurysm,
wherein the vaso-occlusive device comprises:
a detachment junction detachably coupled to a distal end of the elongated pusher member, and
a plurality of inter-woven wires defining (i) a lower member configured to be positioned in a neck of the aneurysm, (ii) an upper member configured to be positioned in a dome of the aneurysm, and (iii) a contiguous middle body portion between the lower member and the upper member,
wherein each inter-woven wire has a first end at the upper member and a second end at the lower member such that the upper member, the contiguous middle body portion, and the lower member are contiguous,
wherein, when the vaso-occlusive device is in the expanded deployed configuration and positioned with the lower member in the neck and the upper member in the dome of the aneurysm, the plurality of inter-woven wires are configured to sit in and cover the neck of the aneurysm and alone cause formation of an embolus to occlude the neck of the aneurysm,
wherein when the vaso-occlusive device is in the expanded deployed configuration, the plurality of inter-woven wires form an external concavity in the lower member and an external concavity in the upper member, and
wherein an entirety of the contiguous middle body portion, between the lower member and the upper member, is expandable when the plurality of inter-woven wires are deployed from the compressed delivery configuration to the expanded deployed configuration.
10. The vaso-occlusive device of claim 9 , wherein in the expanded deployed configuration, the continguous middle body portion has a cylindrical shape.
11. The vaso-occlusive assembly of claim 9 , wherein the detachment junction is configured to detach the vaso-occlusive device from the delivery catheter responsive to at least one stimulus selected from a group consisting of: a mechanical stimulus, an electrolytic stimulus, and a thermal stimulus.
12. The vaso-occlusive device of claim 9 , further comprising a bioactive agent.
13. The vaso-occlusive device of claim 9 , wherein the plurality of inter-woven wires are self-expanding.
14. The vaso-occlusive device of claim 9 , wherein, when the vaso-occlusive device is positioned within the aneurysm in the expanded deployed configuration, the vaso-occlusive device is configured to press against the dome of the aneurysm while the lower member bridges and covers the neck of the aneurysm, and
wherein the aneurysm is a wide neck aneurysm in which the neck has a diameter that is at least 80 percent of a largest diameter of the aneurysm.
15. A method for occluding an aneurysm, comprising:
advancing a vaso-occlusive device in a first, compressed state through a catheter, wherein the vaso-occlusive device is formed of a plurality of inter-woven wires, wherein the plurality of inter-woven wires comprises a first end portion, a second end portion, and a contiguous middle body portion between the first end portion and the second end portion;
deploying the vaso-occlusive device from a distal end of the catheter into a sac of the aneurysm;
expanding an entirety of the contiguous middle body portion, between the first end portion and the second end portion, laterally outward from the compressed state to form a shape to conform to a shape of the sac, wherein the plurality of inter-woven wires form an external concavity in the first end portion and an external concavity in the second end portion of the vaso-occlusive device,
bridging, by the plurality of inter-woven wires of the vaso-occlusive device, a neck of the aneurysm; and
occluding, by the vaso-occlusive device alone causing formation of an embolus, the aneurysm.
16. The method of claim 15 , further comprising responsive to expanding the entirety of the contiguous middle body portion, pressing at least a portion of the vaso-occlusive device against at least a portion of a dome of the aneurysm.
17. The method of claim 15 , wherein bridging, by the plurality of inter-woven wires of the vaso-occlusive device, the neck of the aneurysm comprises the first end portion sitting in and completely covering the neck of the aneurysm.
18. The method of claim 17 , wherein the aneurysm is a wide neck aneurysm in which the neck has a diameter that is at least 80 percent of a largest diameter of the aneurysm.
19. The method of claim 15 , wherein the occluding is performed without another vaso-occlusive device within the aneurysm.
20. The method of claim 15 , wherein the expanding the vaso-occlusive device laterally further comprises forming a substantially spherical interior region defined by the contiguous middle body portion, the first end portion, and the second end portion.