Peritoneal dialysis intracycle osmotic agent adjustment
The invention relates to systems and methods for making intracycle adjustments to an osmotic agent concentration of peritoneal dialysate inside the peritoneal cavity of a patient. The systems and methods include osmotic agent sources, flow paths, and processors to adjust the osmotic agent concentration of dialysate in the peritoneal cavity of the patient. The method can include infusing peritoneal dialysate containing an osmotic agent into the peritoneal cavity of a patient; monitoring one or more patient parameters; and adjusting the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient using an on-line peritoneal dialysis machine. The system can include a peritoneal dialysis cycler.
1. A method, comprising the steps of:
adjusting an osmotic agent concentration of peritoneal dialysate in the peritoneal cavity of a patient during a cycle by infusing a concentrated osmotic agent solution or by infusing sterile fluid into the peritoneal cavity of the patient by infusing the peritoneal dialysate into the peritoneal cavity of the patient at a beginning of the cycle and adjusting the osmotic agent concentration by selectively flowing fluid from an osmotic agent source or a sterile fluid source into the peritoneal cavity of the patient at a set time after infusing the peritoneal dialysate into the peritoneal cavity of the patient.
2. The method of claim 1 , further comprising the step of draining a volume of peritoneal dialysate from the peritoneal cavity of the patient prior to the step of infusing the concentrated osmotic agent solution or infusing the sterile fluid into the peritoneal cavity of the patient.
3. The method of claim 1 , further comprising the step of receiving one or more patient parameters during the cycle.
4. The method of claim 3 , further comprising the step of determining a change to the osmotic agent concentration of the peritoneal dialysate in the peritoneal cavity of the patient based on the one or more patient parameters prior to the step of adjusting the osmotic agent concentration.
5. The method of claim 4 , wherein the patient parameters are selected from the group of: blood pressure; and interperitoneal pressure.
6. The method of claim 4 , further comprising the steps of determining an intraperitoneal pressure at a first time and at least a second time, and wherein the step of determining a change to the osmotic agent concentration comprises determining a change to the osmotic agent concentration based on a change in intraperitoneal pressure.
7. The method of claim 3 , wherein the steps of receiving the one or more patient parameters, and adjusting the osmotic agent concentration of the peritoneal dialysate are performed by a processor of an on-line dialysis machine.
8. The method of claim 7 , wherein the patient parameters are received by the processor while the peritoneal dialysate is inside the patient during the cycle.
9. The method of claim 1 , wherein the step of adjusting the osmotic agent concentration comprises selectively flowing fluid from an osmotic agent source into the peritoneal cavity of the patient.
10. The method of claim 9 , wherein the osmotic agent source contains glucose, dextrose, icodextrin, or combinations thereof.
11. The method of claim 1 , wherein the peritoneal dialysate comprises multiple osmotic agents.
12. The method of claim 11 , wherein the peritoneal dialysate comprises icodextrin and either glucose or dextrose.
13. The method of claim 1 , further comprising the steps of draining the peritoneal dialysate from the patient; and infusing a second peritoneal dialysate into the patient; wherein the second peritoneal dialysate comprises an osmotic agent different from the first peritoneal dialysate.
14. The method of claim 1 , further comprising the steps of:
receiving one or more dialysis results from at least one prior dialysis session into a machine readable storage medium; and receiving a dialysis prescription from the prior dialysis session into a machine readable storage medium;
wherein the one or more dialysis results includes a volume of ultrafiltrate removed and a rate of ultrafiltration and wherein the dialysis prescription comprises an adjustment made to the osmotic agent concentration in the peritoneal cavity of the patient during the prior dialysis session.
15. The method of claim 14 , wherein the step of adjusting the osmotic agent concentration comprises determining a change to the osmotic agent concentration based on the dialysis results from the prior dialysis session and the dialysis prescription from the prior dialysis session.
16. The method of claim 1 , wherein the method is performed by an on-line dialysis machine.
17. The method of claim 1 , wherein the step of infusing the concentrated osmotic agent solution into the patient is performed mid-cycle.
18. The method of claim 1 , wherein the step of infusing the sterile fluid into the peritoneal cavity of the patient is performed mid-cycle.