SPHINGOSINE PATHWAY MODULATING COMPOUNDS FOR THE TREATMENT OF CANCERS
The invention provides methods and compositions for treating cancers and myeloproliferative disorders using sphingosine kinase-1 inhibitors, such as SK1-I, and selective sphingosine-1-phosphate receptor agonists, such as ozanimod.
1 . A method for treating prostate cancer in a mammalian subject, comprising the step of:
administering to a mammalian subject in need of treatment for prostate cancer an effective amount of ozanimod or a pharmaceutically acceptable salt thereof.
2 . The method of claim 1 , wherein the administering step comprises administering the hydrochloride salt of ozanimod to the mammalian subject.
3 . The method of claim 1 , wherein the mammalian subject is a human.
4 . The method of claim 3 , wherein the administering step comprises administering the hydrochloride salt of ozanimod to the mammalian subject.