Treatment for obesity
The present invention relates to a method for treating or preventing obesity in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds. The invention further relates to methods for reducing body weight and/or reducing food intake in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.
1. A method for reducing body weight or body weight gain in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
or a pharmaceutically acceptable salt or ester thereof;
wherein R is a member selected from the group consisting of alkyl of 1 to 8 carbon atoms, halogen, alkoxy of 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy of 1 to 3 carbon atoms;
x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
R 1 and R 2 are independently selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; or
R 1 and R 2 can be joined to form a 5 to 7-membered heterocycle that is unsubstituted or substituted with one or more alkyl or aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
said method comprises administering the compound of Formula (I) to the human subject in a dosing regimen comprising a daily dose of at least 200 mg/day, wherein the compound of Formula (I) or pharmaceutically acceptable salt thereof effects a decrease in body weight or body weight gain in the human subject by at least 0.6 kg from baseline at the 6th week of the dosing regimen.
2. The method of claim 1 , wherein x=0.
3. The method of claim 1 , wherein R 1 and R 2 are hydrogen and x=0.
4. The method of claim 1 , wherein the compound of Formula I is an enantiomer of Formula I substantially free of other enantiomers or an enantiomeric mixture wherein one enantiomer of Formula I predominates.
5. The method of claim 4 , wherein the enantiomer of Formula I predominates to the extent of about 98% or greater.
6. The method of claim 4 , wherein the enantiomer of Formula I is an enantiomer of Formula Ia:
or a pharmaceutically acceptable salt or ester thereof.
7. The method of claim 6 , wherein the enantiomer of Formula Ia is the (R) or (D) enantiomer.
8. The method of claim 6 , wherein the enantiomer of Formula Ia is the (S) or (L) enantiomer.
9. The method of claim 6 , wherein the enantiomer of Formula Ia predominates to the extent of about 98% or greater.
10. The method of claim 4 , wherein the enantiomer of Formula I substantially free of other enantiomers is the compound of Formula Ib or an enantiomeric mixture wherein the compound of Formula Ib predominates:
or a pharmaceutically acceptable salt or ester thereof.
11. The method of claim 10 , wherein the compound of Formula Ib predominates to the extent of about 98% or greater.
12. The method of claim 1 , wherein the compound of Formula I is administered orally.
13. The method of claim 1 , wherein the compound of Formula I is administered in the form of a capsule or tablet.
14. The method of claim 1 , wherein the compound of Formula I is administered in the form of a capsule at a dose of about 10 mg to about 1000 mg without any excipients.