Compounds and uses thereof
The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
1. A compound having the structure of Formula Ic:
wherein
R 1 is
wherein
each of R 3a , R 3b , R 3c , R 3d , and R 3e is, independently, H, F, Cl, Br, I, CN,
L 1 is optionally substituted C1-C6 alkylene; and
R 2 is
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein L 1 is
3. The compound of claim 1 , wherein R 1 is
4. The compound of claim 1 , wherein R 1 is phenyl, 3-fluoro-phenyl, 4-fluoro-phenyl, 3-chloro-phenyl, 4-chloro-phenyl, 2-methoxy-phenyl, 3-methoxy-phenyl, 4-methoxy-phenyl, 3,4-di-fluoro-phenyl, 3,4-dichloro-phenyl, 3,5-di-fluoro-phenyl, 3,5-dichloro-phenyl, 3-chloro-4-fluoro-phenyl, 4-chloro-3-fluoro-phenyl, 3-chloro-4-nitrile-phenyl, 3-nitrile-4-fluoro-phenyl, 3 bromo-phenyl, 3 cyano-5-fluoro-phenyl, 3-chloro-5-fluoro-phenyl, 3-chloro-5-cyano-phenyl, or 3-chloro-5-methoxy-phenyl.
5. The compound of claim 1 , wherein the compound is selected from the group consisting of:
6. A pharmaceutical composition comprising a compound, or pharmaceutically acceptable salt thereof, of claim 1 , and a pharmaceutically acceptable excipient.
7. The compound of claim 1 , wherein the compound has the following structure:
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 2 , wherein the compound is selected from the group consisting of:
9. The compound of claim 3 , wherein the compound is selected from the group consisting of:
10. The compound of claim 1 , wherein the compound is
11. The compound of claim 1 , wherein the compound is
12. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , wherein the compound is
or a pharmaceutically acceptable salt thereof.
16. The compound of claim 1 , wherein the compound is
17. The compound of claim 1 , wherein the compound is
18. The compound of claim 1 , wherein the compound is
19. The compound of claim 1 , wherein the compound is
20. The compound of claim 1 , wherein the compound is