Composite microneedle array including nanostructures thereon
Disclosed are composite microneedles arrays including microneedles and a film overlaying the microneedles. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.
1. A drug delivery device comprising:
a composite microneedle array comprising:
a microneedle assembly that comprises a plurality of microneedles;
a film overlaying at least one microneedle of the microneedle assembly, the film having a first surface and a second surface, wherein the first surface of the film is adhered to the microneedle and at least partially conforms thereto, the film comprising a plurality of nanostructures on the second surface of the film arranged to project outward from the second surface of the film, and wherein at least a portion of the nanostructures have a cross-sectional dimension of less than 500 nanometers and greater than 5 nanometers, a height of from 10 nanometers to 1 micrometer, and an aspect ratio of from 0.2 to 5; and
a reservoir for holding a drug compound, the reservoir being in fluid connection with the microneedle array.
2. The drug delivery device according to claim 1 , wherein at least a portion of the nanostructures of the plurality of nanostructures has a cross-sectional dimension of less than about 400 nanometers and greater than about 10 nanometers.
3. The drug delivery device according to claim 1 , wherein the film further comprises a plurality of microstructures on the second surface of the film, each of the nanostructures of the plurality of nanostructures having a cross-sectional dimension smaller than each of the microstructures of the plurality of microstructures.
4. The drug delivery device according to claim 3 , wherein the plurality of nanostructures comprise first nanostructures and second nanostructures wherein the second nanostructures have a cross-sectional dimension less than a cross-sectional dimension of the plurality of microstructures and greater than a cross-sectional dimension of the first nanostructures.
5. The drug delivery device according to claim 1 , wherein at least a portion of the nanostructures of the plurality of nanostructures has a height of from 100 nanometers to 700 nanometers.
6. The drug delivery device according to claim 1 , wherein at least a portion of the nanostructures of the plurality of nanostructures has an aspect ratio of from 0.5 to 3.5.
7. The drug delivery device according to claim 1 , further comprising a rate control membrane in fluid communication with the reservoir.
8. The drug delivery device according to claim 7 , further comprising a release member that is generally impermeable to the drug compound and positioned adjacent to the rate control membrane.