IP Library › Patent Application 17031433
Patent Application
App. No. 17/031,433

METHODS AND COMPOSITIONS FOR INHIBITING CD32B EXPRESSING CELLS

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Quick Facts
Patent No.
US None
App. No.
17/031,433
Abstract

The present invention relates to immunoglobulins that bind FcγRIIb+ cells and coengage the antigen on the cell's surface and an FcγRIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins.

Claims (6)

1 . A nucleic acid encoding an Fc variant comprising at least amino acid modifications S267E and L328F as compared to a human Fc polypeptide, wherein numbering is according to the EU index according to Kabat.

2 . An expression vector comprising the nucleic acid of claim 1 .

3 . A host cell comprising the vector of claim 2 .

4 . A nucleic acid encoding a heavy chain an antibody, the heavy chain comprising an Fc variant comprising at least amino acid modifications S267E and L328F as compared to a human Fc polypeptide, wherein numbering is according to the EU index according to Kabat.

5 . An expression vector comprising the nucleic acid of claim 4 .

6 . A host cell comprising the vector of claim 5 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 8, 2020
From: CHU, SEUNG YUP; DESJARLAIS, JOHN R.; KARKI, SHER BAHADUR; LAZAR, GREGORY ALAN; MOORE, GREGORY L.; VOSTIAR, IGOR
To: XENCOR, INC.
Reel/Frame 054579/0160 →