COMPOSITIONS, GELS AND FOAMS WITH RHEOLOGY MODULATORS AND USES THEREOF
The present disclosure relates generally to compositions for cosmetic or pharmaceutical application. The compositions include a carrier and rheology modulators.
1 . (canceled)
2 . A method of treating rosacea, comprising administrating a foam composition comprising:
a) a combination of at least one fatty alcohol and at least one wax; or a combination of at least one fatty alcohol, at least one fatty acid, and at least one wax;
b) at least one hydrophobic solvent; and
c) a minocycline at a concentration between about 0.2% and about 20% by weight of the composition;
wherein the composition is free of surfactant;
wherein the composition has a water activity (Aw) value of less than about 0.9; and
wherein the ratio of (1) fatty alcohol to wax or (2) fatty alcohol and fatty acid to wax is between about 1:3 and about 3:1.
3 . The method of claim 2 , wherein the minocycline is present in a free base form, a hydrate form, a salt form, or a complex form.
4 . The method of claim 2 , wherein the foam composition further comprises a doxycycline.
5 . The method of claim 2 , wherein the concentration of the minocycline is between about 1% and about 4% by weight of the composition.
6 . The method of claim 2 , wherein the concentration of the minocycline is about 1.5% by weight of the composition.
7 . The method of claim 2 , wherein the at least one fatty alcohol comprises 14 carbon atoms in its backbone.
8 . The method of claim 2 , wherein the fatty alcohol comprises stearyl alcohol, cetostearyl alcohol, behenyl alcohol, and/or myristyl alcohol.
9 . The method of claim 2 , wherein the at least one fatty alcohol is present at a concentration from about 0.1% to about 20% by weight of the composition.
10 . The method of claim 2 , wherein the at least one wax and/or the at least one fatty acid is present at a concentration from about 0.1% to about 20% by weight of the composition.
11 . The method of claim 2 , wherein the hydrophobic solvent comprises soybean oil, coconut oil, cyclomethicone, and/or mineral oil.
12 . The method of claim 2 , wherein the hydrophobic solvent is present at a concentration from about 60% to about 95% by weight of the composition.
13 . The method of claim 2 , wherein the foam composition further comprises a silicon dioxide.
14 . The method of claim 2 , wherein the wax comprises beeswax and/or hydrogenated castor oil.
15 . The method of claim 2 , wherein the wax comprises beeswax and hydrogenated castor oil.
16 . The method of claim 15 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 5:1 to about 1:1.
17 . The method of claim 15 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 2:1 to about 1:1.
18 . The method of claim 15 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 4:3.
19 . The method of claim 15 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 1:1.
20 . The method of claim 2 , wherein the composition has an Aw value of less than about 0.5.
21 . A method of treating rosacea, comprising administrating a foam composition comprising:
a) a combination of at least one fatty alcohol and at least one wax; or a combination of at least one fatty alcohol, at least one fatty acid, and at least one wax;
b) at least one hydrophobic solvent; and
c) a minocycline at a concentration between about 0.2% and about 20% by weight of the composition;
wherein the composition is free of surfactant;
wherein the composition is essentially waterless; and
wherein the ratio of (1) fatty alcohol to wax or (2) fatty alcohol and fatty acid to wax is between about 1:3 and about 3:1.
22 . The method of claim 21 , wherein the minocycline is present in a free base form, a hydrate form, a salt form, or a complex form.
23 . The method of claim 21 , wherein the foam composition further comprises a doxycycline.
24 . The method of claim 21 , wherein the concentration of the minocycline is between about 1% and about 4% by weight of the composition.
25 . The method of claim 21 , wherein the concentration of the minocycline is about 1.5% by weight of the composition.
26 . The method of claim 21 , wherein the at least one fatty alcohol comprises 14 carbon atoms in its backbone.
27 . The method of claim 21 , wherein the fatty alcohol comprises stearyl alcohol, cetostearyl alcohol, behenyl alcohol, and/or myristyl alcohol.
28 . The method of claim 21 , wherein the at least one fatty alcohol is present at a concentration from about 0.1% to about 20% by weight of the composition.
29 . The method of claim 21 , wherein the at least one wax and/or the at least one fatty acid is present at a concentration from about 0.1% to about 20% by weight of the composition.
30 . The method of claim 21 , wherein the hydrophobic solvent comprises soybean oil, coconut oil, cyclomethicone, and/or mineral oil.
31 . The method of claim 21 , wherein the hydrophobic solvent is present at a concentration from about 60% to about 95% by weight of the composition.
32 . The method of claim 21 , wherein the foam composition further comprises a silicon dioxide.
33 . The method of claim 21 , wherein the wax comprises a mixture of beeswax and/or hydrogenated castor oil.
34 . The method of claim 21 , wherein the wax comprises beeswax and hydrogenated castor oil.
35 . The method of claim 34 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 5:1 to about 1:1.
36 . The method of claim 34 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 2:1 to about 1:1.
37 . The method of claim 34 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 4:3.
38 . The method of claim 34 , wherein the beeswax and hydrogenated castor oil are at a ratio of about 1:1.
39 . The method of claim 21 , wherein the composition has an Aw value of less than about 0.5.