IP Library › Granted Patent US 11,780,839

Granted Patent B2

US 11,780,839 · App. 17/040,104 · Granted Oct 10, 2023

Compounds for treating Huntington's disease

Inventors: Nadiya Sydorenko (Princeton, NJ); Md Rauful Alam (Piscataway, NJ); Lukiana Amedzo (Somerset, NJ); Suresh Babu (Pennington, NJ); Ramil Y. Baiazitov (East Brunswick, NJ); Scott J. Barraza (Piscataway, NJ); Anuradha Bhattacharyya (Edison, NJ); Gary Mitchell Karp (Princeton Junction, NJ); Nathaniel T. Kenton (Highland Park, NJ); Anthony R. Mazzotti (Rahway, NJ); Young-Choon Moon (Belle Mead, NJ); Nicholas W. Mszar (New Brunswick, NJ); Jana Narasimhan (Scotch Plains, NJ); Sudipta Pal (Piscataway, NJ); Jigar S. Patel (Jersey City, NJ); Anthony Turpoff (Hillsborough, NJ); Matthew G. Woll (Dunellen, NJ); Zhenrong Xu (Chalfont, PA); Nanjing Zhang (Princeton, NJ)

Assignee: PTC THERAPEUTICS, INC.

C07D471/08 A61P25/28 C07D401/12 C07D401/14 C07D405/14 C07D409/14 C07D413/14 C07D417/14 C07D471/04 C07D471/10 C07D487/04 C07D491/107 C07D493/08 C07D498/04

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Quick Facts

Patent No.: US 11,780,839
App. No.: 17/040,104
Granted: Oct 10, 2023
Kind: B2

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Abstract

The present description relates to compounds, forms, and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease. In particular, the present description relates to substituted monocyclic heteroaryl compounds of Formula (I) or Formula (II), forms and pharmaceutical compositions thereof and methods of using such compounds, forms, or compositions thereof for treating or ameliorating Huntington's disease.

Claims (774)

1. A compound selected from the group consisting of:

5-(5-methyl-1,3-oxazol-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(2-methoxypyridin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-1,2,3-triazol-4-yl)phenol;

4-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)pyridin-2-ol;

5-(3-methyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-2-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridin-4-yl)phenol;

5-(2-methylpyridin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-methyl-1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-1-yl)phenol;

5-(3-fluoro-1-methyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(piperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(piperidin-3-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-(3-{[(1R,3S,5S)-8-azabicyclo[3.2.1]octan-3-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{[(1R,3S,5S)-9-azabicyclo[3.3.1]nonan-3-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)phenol;

(6-(2-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,2,4-triazin-3-yl)(2,2,6,6-tetramethylpiperidin-4-yl)methanone;

(3-(2-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,2,4-triazin-6-yl)(2,2,6,6-tetramethylpiperidin-4-yl)methanone;

2-(6-(2-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,2,4-triazin-3-yl)-2-(2,2,6,6-tetramethylpiperidin-4-yl)acetonitrile;

2-(3-(2-hydroxy-4-(1H-pyrazol-4-yl)phenyl)-1,2,4-triazin-6-yl)-2-(2,2,6,6-tetramethylpiperidin-4-yl)acetonitrile;

2-(3-(amino(2,2,6,6-tetramethylpiperidin-4-yl)methyl)-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(6-(amino(2,2,6,6-tetramethylpiperidin-4-yl)methyl)-1,2,4-triazin-3-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)-5-(1,3,5-triazin-2-yl)phenol;

2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)-5-(1,3,5-triazin-2-yl)phenol;

4-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1,3,5-triazin-2-ol;

4-(3-hydroxy-4-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenyl)-1,3,5-triazin-2-ol;

5-(4-amino-1,3,5-triazin-2-yl)-2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenol;

5-(4-amino-1,3,5-triazin-2-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenol;

5-(4-chloro-1,3,5-triazin-2-yl)-2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenol

5-(4-chloro-1,3,5-triazin-2-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenol;

2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)-5-(5-methyl-1H-pyrazol-4-yl)phenol;

2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)-5-(5-methyl-1H-pyrazol-4-yl)phenol;

5-(5-chloro-1H-pyrazol-4-yl)-2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenol;

5-(5-chloro-1H-pyrazol-4-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenol;

4-(3-hydroxy-4-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenyl)-1H-pyrazole-5-carbonitrile;

4-(3-hydroxy-4-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenyl)-1H-pyrazole-5-carbonitrile;

5-(1,5-dimethyl-1H-pyrazol-4-yl)-2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenol;

5-(1,5-dimethyl-1H-pyrazol-4-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenol;

5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenol;

5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenol;

4-(3-hydroxy-4-(3-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-6-yl)phenyl)-1-methyl-1H-pyrazole-5-carbonitrile;

4-(3-hydroxy-4-(6-(methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino)-1,2,4-triazin-3-yl)phenyl)-1-methyl-1H-pyrazole-5-carbonitrile;

5-(4-fluoro-1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(3-methyl-1H-1,2,4-triazol-1-yl)phenol;

2-{3-[(1-methylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(thiophen-2-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(4-methylthiophen-2-yl)phenol;

5-(4-methoxy-1H-pyrazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

4-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1-methylpyridin-2(1H)-one;

5-(3-chloro-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,3-thiazol-2-yl)phenol;

5-(4-chloro-1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridazin-4-yl)phenol;

5-(6-methylpyridazin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-1,2,4-triazol-3-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2-methyl-1,3-thiazol-5-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,2,4-thiadiazol-5-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(3-methyl-1,2,4-thiadiazol-5-yl)phenol;

2-{3-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)(methyl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

1-[1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-pyrazol-4-yl]ethan-1-one;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(4-methyl-2H-1,2,3-triazol-2-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridin-3-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridin-2-yl)phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(2-methyl-1,3-oxazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-imidazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-pyrazol-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{[(1R,3s,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{[(1R,3r,5S)-8-azabicyclo[3.2.1]octan-3-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-1,2,4-triazol-1-yl)phenol;

5-(imidazo[1,2-a]pyrazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[(2,6-dimethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyrazin-2-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridazin-3-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyrimidin-2-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyrimidin-5-yl)phenol;

2-(3-{methyl[(1R,3s,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(4-methoxy-1,3,5-triazin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-pyrazol-4-ol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-5-yl)phenol;

5-(imidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-fluoro-1H-pyrazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-methyl-1H-pyrazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-[3-(2,7-diazaspiro[3.5]nonan-7-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

5-(1H-indazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-fluoropyridin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(4-nitro-2H-1,2,3-triazol-2-yl)phenol;

2-[3-(6-amino-3-azabicyclo[3.1.0]hexan-3-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

5-(1-cyclopropyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyrimidin-4-yl)phenol;

4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}[1,1′-biphenyl]-3,4′-diol;

5-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)pyridin-2(1H)-one;

6-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}quinolin-7-ol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,3,4-oxadiazol-2-yl)phenol;

5-(1H-pyrazol-3-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-pyrazol-3-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol;

2-[3-(2,6-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-3-yl)phenol;

5-(5-fluoropyrimidin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-[3-(1-methyl-1,7-diazaspiro[3.5]nonan-7-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3S)-3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(8aS)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2,6-diazaspiro[3.3]heptan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(5-methyl-2H-tetrazol-2-yl)phenol;

2-(3-{[(2R,4s,6S)-2,6-diethylpiperidin-4-yl]oxy}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

5-(6-chloropyridazin-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-pyrazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

4-fluoro-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-5-yl)phenol;

2-{3-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[6-(diethylamino)-3-azabicyclo[3.1.0]hexan-3-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(5-methylpyrimidin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-methylpyrimidin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(2-chloropyrimidin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-b]pyridin-5-yl)phenol;

5-(3-chloro-1H-1,2,4-triazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)pyridazin-3-ol;

1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-pyrazole-4-carbonitrile;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[4,3-b]pyridin-5-yl)phenol;

2-{3-[3-(cyclopropylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-imidazole-4-carbonitrile;

1-[1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-imidazol-4-yl]ethan-1-one;

5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(2-methylimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-tetrazol-5-yl)phenol;

5-(6-methoxy-1,2,4-triazin-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1,3-benzoxazol-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-3-methylpyrimidin-4(3H)-one;

5-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-2-methylpyridazin-3(2H)-one;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(3aS,7aR)-octahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1,2,4-triazin-6-yl}phenol;

2-[3-(2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(3-fluoro-1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(3aS,7aR)-1-methyloctahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1,2,4-triazin-6-yl}phenol;

2-(3-{3-[(2-methylbutan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(tetrazolo[1,5-a]pyridin-7-yl)phenol;

5-(4-fluoro-1H-pyrazol-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{3-[(adamantan-1-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)phenol;

2-(3-{3-[(adamantan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(3,5-dimethyladamantan-1-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-[4-(hydroxymethyl)-1H-pyrazol-1-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[(3aR,4R,6aS)-4-(dimethylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(3-methyl-3H-imidazo[4,5-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-imidazo[4,5-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[(3aR,4S,6aS)-4-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-[3-(5-methyloctahydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3aR,4S,6aS)-4-(dimethylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

3-amino-6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-4-methylpyridin-2-ol;

5-(2,7-dimethyl[1,3]oxazolo[5,4-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{3-[(3-methylpentan-3-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[4-(tert-butylamino)-2-methylpyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-[4-(hydroxymethyl)-2H-1,2,3-triazol-2-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-3-yl)phenol;

5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-indazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(tetrazolo[1,5-b]pyridazin-6-yl)phenol;

5-[6-(hydroxymethyl)pyrimidin-4-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-[3-(2,9-diazaspiro[5.5]undecan-9-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2,8-diazaspiro[4.5]decan-8-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2-methyl-2,9-diazaspiro[5.5]undecan-9-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-c]pyridin-5-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(quinolin-6-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-imidazol-1-yl)phenol;

5-(2H-1,3-benzodioxol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(3-fluoro-1H-pyrazol-4-yl)-2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)phenol;

2-(3-{[(2S)-2-aminopropyl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(5-fluoro-1H-pyrazol-4-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

2-{3-[(3aR,4R,6aS)-4-(tert-butylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-b]pyrazin-5-yl)phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenol;

5-(1-methyl-1H-pyrazol-4-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(4-methyl-1H-imidazol-1-yl)phenol;

5-(1-methyl-1H-pyrazolo[4,3-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-benzotriazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-pyrazol-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-{3-[4-(tert-butylamino)piperidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-indazol-5-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(pyrimidin-2-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-tetrazol-5-yl)phenol;

2-{3-[3-(tert-butylamino)piperidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-pyrazol-3-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

4-(4-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-hydroxyphenyl)-1-methylpyridin-2(1H)-one;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)phenol;

6-(4-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-hydroxyphenyl)-3-methylpyrimidin-4(3H)-one;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(6-methoxypyrimidin-4-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

5-(4-fluoro-1H-pyrazol-1-yl)-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol;

5-(1H-imidazol-1-yl)-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol;

5-(1-methyl-1H-pyrazolo[3,4-c]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-indazol-5-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-1,2,3-triazol-4-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-4-yl)phenol;

4-[3-hydroxy-4-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenyl]-1-methylpyridin-2(1H)-one;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(4-methyl-1H-imidazol-1-yl)phenol

5-(4-fluoro-1H-pyrazol-1-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

5-(4-fluoro-1H-imidazol-1-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

5-(1H-imidazol-1-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2H-1,2,3-triazol-2-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-3-yl)phenol;

6-[3-hydroxy-4-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenyl]-3-methylpyrimidin-4(3H)-one;

5-(5-fluoro-1H-pyrazol-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

5-(2-methyl-2H-1,2,3-triazol-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1,2,4-thiadiazol-5-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-imidazol-1-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(4-methyl-1H-imidazol-1-yl)phenol;

5-(4-fluoro-1H-imidazol-1-yl)-2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)phenol;

4-{3-hydroxy-4-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenyl}-1-methylpyridin-2(1H)-one;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol;

5-(6-methoxypyrimidin-4-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(pyrimidin-2-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-1,2,3-triazol-4-yl)phenol;

6-[4-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-3-hydroxyphenyl]-3-methylpyrimidin-4(3H)-one;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-1,2,3-triazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-2-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2-methyl-2H-tetrazol-5-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1,3-oxazol-2-yl)phenol;

5-(1-methyl-1H-pyrazol-3-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(6-methoxypyrimidin-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

5-(imidazo[1,2-b]pyridazin-6-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

5-(imidazo[1,2-a]pyrazin-6-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-1,2,3-triazol-4-yl)phenol;

5-(2-methyl-2H-tetrazol-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-indazol-5-yl)phenol;

2-[3-(3,5-dimethylpiperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3,5-dimethylpiperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-3-yl)phenol;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(2H-1,2,3-triazol-2-yl)phenol;

5-(6-methoxypyrimidin-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

5-(2-methyl-2H-1,2,3-triazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(2-methyl-2H-tetrazol-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(6-methoxypyrimidin-4-yl)-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1,2,4-thiadiazol-5-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(pyrimidin-2-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1,2,4-thiadiazol-5-yl)phenol;

5-(1H-imidazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-methyl-1H-imidazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-fluoro-1H-imidazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(4-fluoro-1H-pyrazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(2-methyl-1,3-oxazol-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[3-(tert-butylamino)-4-fluoropyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(pyrimidin-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(7-fluoro-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1H-pyrazol-4-yl)-2-[3-(3,3,5,5-tetramethylpiperazin-1-yl)-1,2,4-triazin-6-yl]phenol;

5-(imidazo[1,2-a]pyrazin-6-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol;

5-(1-methyl-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{[(3S,4S)-3-methoxy-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1,3-oxazol-2-yl)phenol;

5-(2-methyl-1,3-oxazol-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(6-methoxypyrimidin-4-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1,2,4-thiadiazol-5-yl)phenol;

2-(3-{[(3S,4S)-3-methoxy-2,2,6,6-tetramethylpiperidin-4-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(imidazo[1,2-b]pyridazin-6-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-3-yl)phenol;

2-(3-{3-[(2-methylpropyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

(3S,4S)-4-({6-[2-hydroxy-4-(1H-pyrazol-4-yl)phenyl]-1,2,4-triazin-3-yl}amino)-2,2,6,6-tetramethylpiperidin-3-ol;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2-methyl-1,3-oxazol-5-yl)phenol;

5-(7-fluoro-1-methyl-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(6,7-difluoro-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(6,7-difluoro-1-methyl-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(8-methylimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(8-methoxyimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,2,4-triazin-6-yl)phenol;

2-{3-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

5-(1,3-oxazol-2-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-(3-{[(3S)-1-methylpyrrolidin-3-yl]oxy}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(4aS,7aS)-1-methyloctahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(4aS,7aR)-4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(oxetan-3-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-pyrazol-4-yl)-2-(3-{3-[(oxetan-3-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

5-(pyridazin-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-[(pyridin-3-yl)amino]-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{3-[(1-fluoro-2-methylpropan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(ethylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(dimethylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-indazol-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-tetrazol-5-yl)phenol;

5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

2-(3-{3-[(3-methyloxetan-3-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(4-methyl-1H-imidazol-1-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-{3-[(3aR,7aR)-octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-[3-(piperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3S)-3-{[(2R)-1-fluoropropan-2-yl]amino}pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-indazol-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

5-(1H-imidazol-1-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-{3-[(3aR,6aS)-hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(2-hydroxyethyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-(8-amino-2-oxa-6-azaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(oxan-4-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(1-methoxypropan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

5-(4-fluoro-1H-pyrazol-1-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol;

2-[3-(1,7-diazaspiro[4.4]nonan-7-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(1-methylcyclopropyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(1-methoxy-2-methylpropan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

5-(1-methyl-1H-indazol-5-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

5-(1-methyl-1H-pyrazol-3-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)imidazo[1,2-b]pyridazine-8-carbonitrile;

2-(3-{[(3R,4S)-3-fluoropiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3R,4R)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-(3-{(3S)-3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{(3R)-3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(bicyclo[1.1.1]pentan-1-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-1,3-oxazol-5-yl)phenol;

5-[8-(aminomethyl)imidazo[1,2-b]pyridazin-6-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(1,3-oxazol-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-[3-(6-oxa-2,9-diazaspiro[4.5]decan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(2,7-diazaspiro[4.4]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3S)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol

2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(cyclopentylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-2-yl)phenol;

5-(imidazo[1,2-a]pyrazin-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

5-(imidazo[1,2-a]pyridin-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-[3-(3-{[(propan-2-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(4-methyloxan-4-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-[6-(methylsulfanyl)pyrimidin-4-yl]phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-chloro-1H-pyrazol-4-yl)phenol;

4-(4-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-hydroxyphenyl)-1H-pyrazole-3-carbonitrile;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]phenol;

3-(1-methyl-1H-pyrazol-3-yl)-6-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}benzene-1,2-diol;

2-[3-(2,7-diazaspiro[4.5]decan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(3-hydroxypropyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3-{[(oxan-4-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-3-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-methyl-1H-pyrazol-4-yl)phenol;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-methoxy-5-(1H-pyrazol-4-yl)phenol;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]phenol;

2-{3-[(3S)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol;

2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol;

5-[6-(methylamino)pyrimidin-4-yl]-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-c]pyridin-1-yl)phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(pyridin-4-yl)phenol;

5-(7-fluoro-1H-indazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(pyridin-3-yl)phenol;

2-{3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(imidazo[1,2-b]pyridazin-6-yl)phenol;

2-(3-{3-[(cyclopentylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-([2,3′-bipyrrolidin]-1′-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

5-(1H-pyrazol-4-yl)-2-{3-[3-({[(pyridin-2-yl)methyl]amino}methyl)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol;

2-[3-(3-amino-3-methylpyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-(3-{3-[(tert-butylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3-{[(4-methyloxan-4-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(cyclopropylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(pyridin-2-yl)phenol;

5-(1-methyl-1H-pyrazolo[4,3-b]pyridin-5-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

2-[3-(3-{[(oxolan-3-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol;

2-{3-[(3S)-3-{[(oxan-4-yl)amino]methyl}pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3R)-3-{[(oxan-4-yl)amino]methyl}pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3R)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3S)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol;

2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(pyrimidin-2-yl)phenol;

2-[3-(3-{[(3-fluorooxan-4-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3-{[(oxan-3-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3-{[(8-oxabicyclo[3.2.1]octan-3-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-{3-[(3R)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-{3-[(3S)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-(3-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-(3-{3-[(3,3-difluorocyclopentyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(dimethylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(pyrimidin-4-yl)phenol;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(pyrazin-2-yl)phenol;

2-(3-{3-[(methylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3-{1-[(propan-2-yl)amino]ethyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(cyclobutylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-[(cyclobutylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-(3-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(2H-1,2,3-triazol-2-yl)phenol;

6-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-2-fluoro-3-(1H-pyrazol-4-yl)phenol;

5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-3-yl}phenol;

2-(3-{3-[(3-fluorocyclopentyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol;

2-[3-(3-{1-[(oxan-4-yl)amino]cyclopropyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol;

2-(3-{3-methyl-3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol;

2-{6-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)phenol; and

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol,

wherein a form of the compound is selected from the group consisting of a salt, hydrate, solvate, racemate, enantiomer, diastereomer, stereoisomer, and tautomer form thereof.

2. The compound of claim 1 wherein the form of the compound is a compound salt selected from hydrochloride, hydrobromide, trifluoroacetate, formate, dihydrochloride, dihydroiodide, trihydrochloride, tetrahydrochloride, dihydrobromide and ditrifluoroacetate.

3. A compound, wherein the compound is a compound salt or a form thereof selected from the group consisting of:

5-(5-methyl-1,3-oxazol-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrobromide;

5-(6-methoxypyrimidin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(2-methoxypyridin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(3-methyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(4-methyl-1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol ditrifluoroacetate;

5-(1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol hydrochloride;

5-(1-methyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(3-fluoro-1-methyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[methyl(piperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(piperidin-3-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol hydrochloride;

2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)phenol hydrobromide;

5-(4-fluoro-1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(3-methyl-1H-1,2,4-triazol-1-yl)phenol hydrochloride;

2-{3-[(1-methylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol trihydrochloride;

5-(4-methoxy-1H-pyrazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(3-chloro-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,3-thiazol-2-yl)phenol hydrochloride;

5-(4-chloro-1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridazin-4-yl)phenol dihydrochloride;

5-(6-methylpyridazin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-1,2,4-triazol-3-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,2,4-thiadiazol-5-yl)phenol hydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(3-methyl-1,2,4-thiadiazol-5-yl)phenol hydrochloride;

2-{3-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)(methyl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

1-[1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-pyrazol-4-yl]ethan-1-one dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(4-methyl-2H-1,2,3-triazol-2-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridin-2-yl)phenol formate;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol trihydrochloride;

5-(2-methyl-1,3-oxazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(1-methyl-1H-imidazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(1-methyl-1H-pyrazol-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-(3-{[(1R,3s,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-1,2,4-triazol-1-yl)phenol dihydrochloride;

5-(imidazo[1,2-a]pyrazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[(2,6-dimethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyridazin-3-yl)phenol formate;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyrimidin-5-yl)phenol formate;

5-(4-methoxy-1,3,5-triazin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(1H-imidazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-pyrazol-4-ol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-5-yl)phenol hydrochloride;

5-(imidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(4-fluoro-1H-pyrazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(4-methyl-1H-pyrazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-[3-(2,7-diazaspiro[3.5]nonan-7-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(1H-indazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(4-nitro-2H-1,2,3-triazol-2-yl)phenol dihydrochloride;

5-(1-cyclopropyl-1H-pyrazol-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(pyrimidin-4-yl)phenol formate;

4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}[1,1′-biphenyl]-3,4′-diol formate;

6-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}quinolin-7-ol hydrobromide;

5-(1H-pyrazol-3-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol ditrifluoroacetate;

5-(1-methyl-1H-pyrazol-3-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}phenol trifluoroacetate;

2-[3-(2,6-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-3-yl)phenol trifluoroacetate;

5-(5-fluoropyrimidin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-[3-(1-methyl-1,7-diazaspiro[3.5]nonan-7-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3S)-3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(7S)-7-amino-5-azaspiro[2.4]heptan-5-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(8aS)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3aR,6aR)-1-methylhexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2,6-diazaspiro[3.3]heptan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(5-methyl-2H-tetrazol-2-yl)phenol dihydrochloride;

2-(3-{[(2R,4s,6S)-2,6-diethylpiperidin-4-yl]oxy}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol trifluoroacetate;

2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol dihydrochloride;

2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol hydrochloride;

5-(6-chloropyridazin-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(1-methyl-1H-pyrazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[6-(diethylamino)-3-azabicyclo[3.1.0]hexan-3-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol hydrochloride;

5-(5-methylpyrimidin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(4-methylpyrimidin-2-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(2-chloropyrimidin-4-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-b]pyridin-5-yl)phenol formate;

5-(3-chloro-1H-1,2,4-triazol-1-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)pyridazin-3-ol hydrochloride;

1-[1-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-1H-imidazol-4-yl]ethan-1-one dihydrochloride;

5-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(2-methylimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-tetrazol-5-yl)phenol dihydrochloride;

6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-3-methylpyrimidin-4(3H)-one dihydrochloride;

5-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-2-methylpyridazin-3(2H)-one dihydrochloride;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol hydrochloride;

2-[3-(2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(3-fluoro-1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)phenol dihydrochloride;

5-(3-fluoro-1H-pyrazol-4-yl)-2-{3-[(3aS,7aR)-1-methyloctahydro-5H-pyrrolo[3,2-c]pyridin-5-yl]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(tetrazolo[1,5-a]pyridin-7-yl)phenol dihydrochloride;

5-(4-fluoro-1H-pyrazol-3-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol trifluoroacetate;

2-(3-{3-[(adamantan-1-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol ditrifluoroacetate;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(5H-pyrrolo[2,3-b]pyrazin-2-yl)phenol formate;

2-(3-{3-[(adamantan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol ditrifluoroacetate;

2-(3-{3-[(3,5-dimethyladamantan-1-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol ditrifluoroacetate;

5-[4-(hydroxymethyl)-1H-pyrazol-1-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[(3aR,4R,6aS)-4-(dimethylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(1-methyl-1H-imidazo[4,5-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[(3aR,4S,6aS)-4-aminohexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(5-methyloctahydro-2H-pyrrolo[3,4-c]pyridin-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3aR,4S,6aS)-4-(dimethylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

3-amino-6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)-4-methylpyridin-2-ol dihydrochloride;

5-(2,7-dimethyl[1,3]oxazolo[5,4-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol diformate;

5-[4-(hydroxymethyl)-2H-1,2,3-triazol-2-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(3-methyl-3H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)phenol hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-3-yl)phenol trifluoroacetate;

5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(1-methyl-1H-indazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(tetrazolo[1,5-b]pyridazin-6-yl)phenol dihydrochloride;

5-[6-(hydroxymethyl)pyrimidin-4-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-[3-(2,9-diazaspiro[5.5]undecan-9-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2,8-diazaspiro[4.5]decan-8-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2-methyl-2,9-diazaspiro[5.5]undecan-9-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2-methyl-2,8-diazaspiro[4.5]decan-8-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-c]pyridin-5-yl)phenol formate;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(quinolin-6-yl)phenol trifluoroacetate;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)phenol hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-imidazol-1-yl)phenol ditrifluoroacetate;

5-(2H-1,3-benzodioxol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(3-fluoro-1H-pyrazol-4-yl)-2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)phenol dihydrochloride;

2-(3-{[(2S)-2-aminopropyl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(5-fluoro-1H-pyrazol-4-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol hydrochloride;

2-{3-[(3aR,4R,6aS)-4-(tert-butylamino)hexahydrocyclopenta[c]pyrrol-2(1H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-b]pyrazin-5-yl)phenol formate;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[4,3-d]pyrimidin-5-yl)phenol formate;

5-(1-methyl-1H-pyrazol-4-yl)-2-{6-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(4-methyl-1H-imidazol-1-yl)phenol ditrifluoroacetate;

5-(1-methyl-1H-pyrazolo[4,3-b]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(1-methyl-1H-pyrazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(1-methyl-1H-benzotriazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol hydrochloride;

5-(1-methyl-1H-pyrazol-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol hydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol hydrochloride;

2-{3-[4-(tert-butylamino)piperidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol trifluoroacetate;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-([1,2,3]triazolo[1,5-a]pyridin-5-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-indazol-5-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(pyrimidin-2-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-tetrazol-5-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)piperidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol trifluoroacetate;

5-(1-methyl-1H-pyrazol-3-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

4-(4-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-hydroxyphenyl)-1-methylpyridin-2(1H)-one hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-yl)phenol hydrochloride;

6-(4-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-hydroxyphenyl)-3-methylpyrimidin-4(3H)-one hydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(6-methoxypyrimidin-4-yl)phenol ditrifluoroacetate;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol trihydrochloride;

5-(4-fluoro-1H-pyrazol-1-yl)-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol trihydrochloride;

5-(1H-imidazol-1-yl)-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol trihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol dihydrochloride;

5-(1-methyl-1H-pyrazolo[3,4-c]pyridin-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-indazol-5-yl)phenol trifluoroacetate;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol trifluoroacetate;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-4-yl)phenol trifluoroacetate;

4-[3-hydroxy-4-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenyl]-1-methylpyridin-2(1H)-one hydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(4-methyl-1H-imidazol-1-yl)phenol hydrochloride;

5-(4-fluoro-1H-pyrazol-1-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol hydrochloride;

5-(4-fluoro-1H-imidazol-1-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol hydrochloride;

5-(1H-imidazol-1-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol hydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2H-1,2,3-triazol-2-yl)phenol hydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-3-yl)phenol hydrochloride;

6-[3-hydroxy-4-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenyl]-3-methylpyrimidin-4(3H)-one hydrochloride;

5-(5-fluoro-1H-pyrazol-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

5-(2-methyl-2H-1,2,3-triazol-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1,2,4-thiadiazol-5-yl)phenol hydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-imidazol-1-yl)phenol dihydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(4-methyl-1H-imidazol-1-yl)phenol dihydrochloride;

5-(4-fluoro-1H-imidazol-1-yl)-2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)phenol dihydrochloride;

4-{3-hydroxy-4-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenyl}-1-methylpyridin-2(1H)-one hydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol trifluoroacetate;

5-(6-methoxypyrimidin-4-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol ditrifluoroacetate;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(pyrimidin-2-yl)phenol trifluoroacetate;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-1,2,3-triazol-4-yl)phenol trifluoroacetate;

6-[4-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-3-hydroxyphenyl]-3-methylpyrimidin-4(3H)-one dihydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-1,2,3-triazol-4-yl)phenol dihydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(imidazo[1,2-b]pyridazin-6-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-2-yl)phenol hydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2-methyl-2H-tetrazol-5-yl)phenol trifluoroacetate;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1,3-oxazol-2-yl)phenol trifluoroacetate;

5-(1-methyl-1H-pyrazol-3-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(6-methoxypyrimidin-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(imidazo[1,2-b]pyridazin-6-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol trifluoroacetate;

5-(imidazo[1,2-a]pyrazin-6-yl)-2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]phenol hydrochloride;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-1,2,3-triazol-4-yl)phenol diftrifluoroacetate;

5-(2-methyl-2H-tetrazol-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol ftrifluoroacetate;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-indazol-5-yl)phenol dihydrochloride 2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-3-yl)phenol dihydrochloride;

2-[3-(3,5-dimethylpiperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(3,5-dimethylpiperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1-methyl-1H-pyrazol-3-yl)phenol hydrochloride;

2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(2H-1,2,3-triazol-2-yl)phenol hydrochloride;

5-(6-methoxypyrimidin-4-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

5-(2-methyl-2H-1,2,3-triazol-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(2-methyl-2H-tetrazol-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol dihydrochloride;

5-(6-methoxypyrimidin-4-yl)-2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol diftrifluoroacetate;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1,2,4-thiadiazol-5-yl)phenol dihydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(pyrimidin-2-yl)phenol dihydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol dihydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1,2,4-thiadiazol-5-yl)phenol ftrifluoroacetate;

5-(1H-imidazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(4-methyl-1H-imidazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(4-fluoro-1H-imidazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(4-fluoro-1H-pyrazol-1-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(2-methyl-1,3-oxazol-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{3-[3-(tert-butylamino)-4-fluoropyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol hydrochloride;

5-(pyrimidin-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(1H-pyrazol-4-yl)-2-[3-(3,3,5,5-tetramethylpiperazin-1-yl)-1,2,4-triazin-6-yl]phenol dihydrochloride;

5-(imidazo[1,2-a]pyrazin-6-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)phenol dihydrochloride;

5-(1-methyl-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol ftrifluoroacetate;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1,3-oxazol-2-yl)phenol ftrifluoroacetate;

5-(2-methyl-1,3-oxazol-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(6-methoxypyrimidin-4-yl)phenol ftrifluoroacetate;

2-(3-{[(3S,4S)-3-methoxy-2,2,6,6-tetramethylpiperidin-4-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(imidazo[1,2-b]pyridazin-6-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-1,2,3-triazol-4-yl)phenol dihydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-3-yl)phenol dihydrochloride;

2-(3-{3-[(2-methylpropyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

(3S,4S)-4-({6-[2-hydroxy-4-(1H-pyrazol-4-yl)phenyl]-1,2,4-triazin-3-yl}amino)-2,2,6,6-tetramethylpiperidin-3-ol dihydrochloride;

2-[3-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(2-methyl-1,3-oxazol-5-yl)phenol ftrifluoroacetate;

5-(7-fluoro-1-methyl-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(6,7-difluoro-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(6,7-difluoro-1-methyl-1H-benzimidazol-5-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(8-methylimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(8-methoxyimidazo[1,2-b]pyridazin-6-yl)-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1,2,4-triazin-6-yl)phenol ftrifluoroacetate;

2-{3-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

5-(1,3-oxazol-2-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-(3-{[(3S)-1-methylpyrrolidin-3-yl]oxy}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol hydrochloride;

2-{3-[(4aS,7aS)-1-methyloctahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol trihydrochloride;

2-{3-[(4aS,7aR)-4-methylhexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol trihydrochloride;

5-(pyridazin-4-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-[(pyridin-3-yl)amino]-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

2-(3-{3-[(1-fluoro-2-methylpropan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol hydrochloride;

2-{3-[3-(ethylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[3-(dimethylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydroiodide;

5-(1-methyl-1H-indazol-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol trihydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-2H-tetrazol-5-yl)phenol trihydrochloride;

5-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol trihydrochloride;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{[(3R,4R)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(2H-1,2,3-triazol-2-yl)phenol dihydrochloride;

5-(4-methyl-1H-imidazol-1-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-{3-[(3aR,7aR)-octahydro-2H-pyrrolo[3,4-c]pyridin-2-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol trihydrochloride;

2-[3-(piperazin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3S)-3-{[(2R)-1-fluoropropan-2-yl]amino}pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(1-methyl-1H-indazol-5-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

5-(1H-imidazol-1-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-{3-[(3aR,6aS)-hexahydropyrrolo[3,2-b]pyrrol-1(2H)-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(2-hydroxyethyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(oxan-4-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(1-methoxypropan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(4-fluoro-1H-pyrazol-1-yl)-2-(3-{3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)phenol hydrochloride;

2-[3-(1,7-diazaspiro[4.4]nonan-7-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(1-methylcyclopropyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(1-methoxy-2-methylpropan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

6-(3-hydroxy-4-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenyl)imidazo[1,2-b]pyridazine-8-carbonitrile formate;

2-(3-{[(3R,4S)-3-fluoropiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3R,4R)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{(3S)-3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol ftrifluoroacetate;

2-(3-{(3R)-3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol ftrifluoroacetate;

2-(3-{3-[(bicyclo[1.1.1]pentan-1-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol ftrifluoroacetate;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(2-methyl-1,3-oxazol-5-yl)phenol dihydrochloride;

5-[8-(aminomethyl)imidazo[1,2-b]pyridazin-6-yl]-2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

5-(1,3-oxazol-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol formate;

2-[3-(6-oxa-2,9-diazaspiro[4.5]decan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(2,7-diazaspiro[4.4]nonan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3S)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[3-(cyclopentylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1,3-oxazol-2-yl)phenol dihydrochloride;

5-(imidazo[1,2-a]pyrazin-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

5-(imidazo[1,2-a]pyridin-2-yl)-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-[3-(3-{[(propan-2-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(4-methyloxan-4-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol diftrifluoroacetate;

2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[3-(methylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-[6-(methylsulfanyl)pyrimidin-4-yl]phenol trihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-chloro-1H-pyrazol-4-yl)phenol dihydrochloride;

4-(4-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-hydroxyphenyl)-1H-pyrazole-3-carbonitrile dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]phenol hydrochloride;

3-(1-methyl-1H-pyrazol-3-yl)-6-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}benzene-1,2-diol ftrifluoroacetate;

2-[3-(2,7-diazaspiro[4.5]decan-2-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(hexahydropyrrolo[3,4-b]pyrrol-5(1H)-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(3-hydroxypropyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(3-{[(oxan-4-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol diftrifluoroacetate;

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{3-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}phenol hydrochloride;

2-{6-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-3-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-methyl-1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-3-methoxy-5-(1H-pyrazol-4-yl)phenol ftrifluoroacetate;

2-(3-{[(3S,4S)-3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl]amino}-1,2,4-triazin-6-yl)-5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]phenol hydrochloride;

2-{3-[(3S)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3R)-3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(3-fluoro-1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[methyl(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-6-yl}-5-(1H-pyrazolo[3,4-c]pyridin-1-yl)phenol formate;

2-{3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-1,2,4-triazin-6-yl}-5-(imidazo[1,2-b]pyridazin-6-yl)phenol ftrifluoroacetate;

2-(3-{3-[(cyclopentylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-([2,3′-bipyrrolidin]-1′-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(1H-pyrazol-4-yl)-2-{3-[3-({[(pyridin-2-yl)methyl]amino}methyl)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}phenol diftrifluoroacetate;

2-(3-{3-[(tert-butylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(3-{[(4-methyloxan-4-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol ftrifluoroacetate;

2-(3-{3-[(cyclopropylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol formate;

2-[3-(3-{[(oxolan-3-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol hydrochloride;

5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol hydrochloride;

2-{3-[(3R)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{3-[(3S)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(2H-1,2,3-triazol-2-yl)phenol hydrochloride;

2-[3-(3-{[(3-fluorooxan-4-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol hydrochloride;

2-[3-(3-{[(oxan-3-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol hydrochloride;

2-[3-(3-{[(8-oxabicyclo[3.2.1]octan-3-yl)amino]methyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol hydrochloride;

2-{3-[(3R)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol hydrochloride;

2-{3-[(3S)-3-(cyclobutylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-5-(1-methyl-1H-pyrazol-4-yl)phenol hydrochloride;

2-(3-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol ftrifluoroacetate;

2-(3-{3-[(3,3-difluorocyclopentyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(dimethylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(methylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(3-{1-[(propan-2-yl)amino]ethyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(cyclobutylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-[(cyclobutylamino)methyl]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol hydrochloride;

2-(3-{[(1R,3s,5S)-1,5-dimethyl-8-azabicyclo[3.2.1]octan-3-yl](methyl)amino}-1,2,4-triazin-6-yl)-5-(2H-1,2,3-triazol-2-yl)phenol ftrifluoroacetate;

6-{3-[3-(tert-butylamino)pyrrolidin-1-yl]-1,2,4-triazin-6-yl}-2-fluoro-3-(1H-pyrazol-4-yl)phenol dihydrochloride;

5-(1H-pyrazol-4-yl)-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)oxy]-1,2,4-triazin-3-yl}phenol hydrochloride;

2-(3-{3-[(3-fluorocyclopentyl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-[3-(3-{1-[(oxan-4-yl)amino]cyclopropyl}pyrrolidin-1-yl)-1,2,4-triazin-6-yl]-5-(1H-pyrazol-4-yl)phenol dihydrochloride;

2-(3-{3-methyl-3-[(propan-2-yl)amino]pyrrolidin-1-yl}-1,2,4-triazin-6-yl)-5-(1-methyl-1H-pyrazol-4-yl)phenol trifluoroacetate;

2-{6-[(3-fluoro-2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}-5-(1H-pyrazol-4-yl)phenol hydrochloride; and

5-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-2-{6-[(2,2,6,6-tetramethylpiperidin-4-yl)amino]-1,2,4-triazin-3-yl}phenol hydrochloride,

wherein a form of the compound is selected from the group consisting of a salt, hydrate, solvate, racemate, enantiomer, diastereomer, stereoisomer, and tautomer form thereof.

4. A pharmaceutical composition comprising the compound, or form thereof, of claim 1 in admixture with one or more pharmaceutically acceptable excipients.

5. A pharmaceutical composition comprising the compound salt of claim 2 in admixture with one or more pharmaceutically acceptable excipients.

6. A pharmaceutical composition comprising the compound, or form thereof, of claim 3 in admixture with one or more pharmaceutically acceptable excipients.

7. A method for treating or ameliorating Huntington's Disease (HD) in a subject in need thereof comprising, administering to the subject an effective amount of the compound, or form thereof, of claim 1 .

8. The method of claim 7 , wherein the effective amount of the compound, or form thereof, is in a range of from about 0.001 mg/kg/day to about 500 mg/kg/day.

9. A method for treating or ameliorating Huntington's Disease (HD) in a subject in need thereof comprising, administering to the subject an effective amount of the compound salt of claim 2 .

10. The method of claim 9 , wherein the effective amount of the compound salt is in a range of from about 0.001 mg/kg/day to about 500 mg/kg/day.

11. A method for treating or ameliorating Huntington's Disease (HD) in a subject in need thereof comprising, administering to the subject an effective amount of the compound, or form thereof, of claim 3 .

12. The method of claim 11 , wherein the effective amount of the compound or form thereof is in a range of from about 0.001 mg/kg/day to about 500 mg/kg/day.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 28, 2020

From: SYDORENKO, NADIYA; ALAM, MD RAUFUL; AMEDZO, LUKIANA; BABU, SURESH; BAIAZITOV, RAMIL Y.; BARRAZA, SCOTT J.; BHATTACHARYYA, ANURADHA; KARP, GARY MITCHELL; KENTON, NATHANIEL T.; MAZZOTTI, ANTHONY R.; MOON, YOUNG-CHOON; MSZAR, NICHOLAS W.; NARASIMHAN, JANA; PAL, SUDIPTA; PATEL, JIGAR S.; TURPOFF, ANTHONY; WOLL, MATTHEW G.; XU, ZHENRONG; ZHANG, NANJING

To: PTC THERAPEUTICS, INC.

Reel/Frame 053902/0407 →

Continuity (2)

Provisional Application 62648699 · Mar 27, 2018

Related Publication 20210024525A1 · Jan 28, 2021