Evaporator system
The present invention relates to a method of manufacturing spray-dried powders. During the process, a solvent is used. The process is done in multiple steps such that the emulsification mass ratio is low when removal of the solvent is started. Preferred solvents are isopropyl acetate and ethyl acetate. The invention also relates to a set-up to run the inventive process at industrial scale.
1. A system comprising an evaporator, a first mixing unit, a first vessel, a second vessel, and a second mixing unit,
wherein the evaporator has a feed inlet, a vapor outlet and a liquid outlet,
wherein the evaporator, the first mixing unit, the first vessel, and the second mixing unit are arranged such that a liquid composition can be fed from the first vessel into the first mixing unit, from the first mixing unit into the evaporator through the feed inlet of the evaporator, and from the evaporator through the liquid outlet of the evaporator into the second mixing unit,
wherein the second vessel is arranged such that a liquid composition can be fed from the second vessel into (a) the first mixing unit and (b) into the second mixing unit without passing through the first mixing unit and
wherein the first mixing unit or the second mixing unit comprise a high-pressure homogenizer, a colloid mill, a nozzle, or a rotor-stator homogenizer.
2. The system according to claim 1 ,
wherein the system further comprises:
(i) a means to control flow from the second vessel into the first mixing unit and/or into the second mixing unit,
(ii) a pump to control flow from the second vessel into the first mixing unit, and/or
(iii) a pump to control flow from the second vessel into the second mixing unit, and/or
(iv) a means to control flow from the first vessel into the first mixing unit, and/or
(v) a pump to control flow from the first vessel into the first mixing unit.
3. The system according to claim 1 ,
wherein the second vessel is connected to the second mixing unit by a connection, optionally wherein said connection is a tube, a pipe, a channel, a funnel, a course, a conduit, or a duct, and
optionally wherein said connection has a length of at least 2 meters.
4. The system according to claim 3 , wherein said connection is a tube, a pipe, a channel, a funnel, a course, a conduit, or a duct, and wherein said connection has a length of at least 10 meters.
5. The system according to claim 4 , wherein said connection has a length of at least 100 meters.
6. The system according to claim 1 , wherein the first vessel and the second vessel are both individually capable of holding a volume of at least 100 liters.
7. The system according to claim 6 , wherein the first vessel and the second vessel are both individually capable of holding a volume of at least 500 liters.
8. The system according to claim 7 , wherein the first vessel and the second vessel are both individually capable of holding a volume of at least 3000 liters.
9. The system according to claim 1 , further comprising an apparatus for spray-drying.