IP Library › Patent Application 17052141
Patent Application
App. No. 17/052,141

METHODS OF TREATING BACTERIAL INFECTIONS WITH MINOCYCLINE

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Patent No.
US None
App. No.
17/052,141
Abstract

Disclosed herein are methods of treating carbapenem-resistant bacterial infections in a subject using various dosages of minocycline.

Claims (16)

1 . A method of treating one or more bacterial infection in a subject, wherein the infection is carbapenem-resistant, comprising administering minocycline to the subject in need thereof at a dose of greater than 200 mg.

2 . The method of claim 1 , wherein the bacterial infection is selected from the group consisting of Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterobacter cloacae species complex, Enterococcus faecium, Serratia marcescens. Streptococcus pyogenes, Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia trachomatis, Mycoplasma pneumoniae, Legionella pneumophila, Acinetobacter baumannii, Bartonella bacilliformis, Brucella species, Calymmatobacterium granulomatis, Campylobacter fetus, Francisella tularensis, Haemophilus ducreyi, Vibrio cholerae , and Yersinia pestis.

3 . The method of claim 2 , wherein the bacterial infection is Acinetobacter baumannii.

4 . The method of claim 1 , wherein the administration is oral, intravenous, intraperitoneal, intragastric, or intravascular administration.

5 . The method of claim 4 , wherein the administration is intravenous administration.

6 . The method of claim 1 , wherein the dose of the minocycline administered is from about 250 mg to about 1000 mg.

7 . The method of claim 6 , wherein the dose of minocycline is at least about 300 mg.

8 . The method of claim 6 , wherein the dose of minocycline is at least about 400 mg.

9 . The method of claim 6 , wherein the dose of minocycline is at least about 500 mg.

10 . The method of claim 6 , wherein the dose of minocycline is at least about 600 mg.

11 . The method of claim 1 , wherein the dose of minocycline is administered from one to four times daily.

12 . The method of claim 11 wherein the dose of minocycline is administered two times daily.

13 . The method of claim 12 wherein the dose of minocycline is administered three times daily.

14 . The method of claim 1 , wherein an initial loading dose of about 600 mg minocycline is administered.

15 . The method of claim 14 , wherein a dose of from about 100 mg to about 600 mg minocycline is administered twice daily.

16 . The method of claim 1 , wherein the minocycline is administered from about 1 day to at least about 4 weeks.

Assignments (2)
TERMINATION AND RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT (PATENTS) AT REEL 054836 AND FRAME 0765 AND REEL 061314 AND 0459 Recorded Aug 29, 2025
From: SILICON VALLEY BANK, A DIVISION OF FIRST-CITIZENS BANK & TRUST COMPANY
To: MELINTA THERAPEUTICS, LLC
Reel/Frame 072772/0097 →
AMENDED AND RESTATED INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Aug 25, 2022
From: MELINTA THERAPEUTICS, LLC
To: SILICON VALLEY BANK
Reel/Frame 061314/0459 →