US 5767250A
· Spaete
· 1998
[cited by applicant]
US 9399059B2
· Morrison
· 2016
[cited by examiner]
US 9683022B2
· Carfi
· 2017
[cited by applicant]
CN 106456724A
· 2017
[cited by applicant]
CN 107875382A
· 2018
[cited by applicant]
EP 2222710
· 2016
[cited by applicant]
GB 17057506
· 2017
[cited by applicant]
GB 17064304
· 2017
[cited by applicant]
WO WO2011098772A1
· 2011
[cited by applicant]
WO 2012034025A2
· 2012
[cited by applicant]
WO WO2014005959A1
· 2014
[cited by applicant]
WO WO2014160463A1
· 2014
[cited by applicant]
WO WO2016067239A1
· 2016
[cited by applicant]
WO WO2016112921A1
· 2016
[cited by examiner]
WO WO2016193746A1
· 2016
[cited by applicant]
WO WO2017172890A1
· 2017
[cited by applicant]
WO WO2018189517A1
· 2018
[cited by applicant]
WO WO2018197854A1
· 2018
[cited by applicant]
Brune et al. Sci Rep vol. 6, 19234, pp. 1-13 (Year: 2016).
[cited by examiner]
Wussow et al., Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex. PLoS Pathog 10(11): e1004524). (Year: 2014).
[cited by examiner]
Gordon et al., The Journal of Infectious Diseases, vol. 171, No. 6, pp. 1576-1585 (Year: 1995).
[cited by examiner]
Chang et al., Cold Spring Harb Perspect Med Mar. 2015;5:a021493 (doi: 10.1101/cshperspect.a021493)). (Year: 2015).
[cited by examiner]
Wussow et al., Vaccines , 5(4), 39 (Year: 2017).
[cited by examiner]
Spaete et al., Virology vol. 193, pp. 853-861 (Year: 1993).
[cited by examiner]
Altschul, S.F., “A protein alignment scoring system sensitive at all evolutionary distances,”
[cited by applicant]
Altschul, S.F. et al., “Basic Local Alignment Search Tool,”
[cited by applicant]
Arai, R. et al., “Design of the linkers which effectively separate domains of a bifunctional fusion protein,”
[cited by applicant]
Brune, K.D. et al., “Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization,”
[cited by applicant]
Brune, K.D. et al., “Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization,”
[cited by applicant]
Bruun, T.U.J. et al., “Engineering a Rugged Nanoscaffold To Enhance Plug-and-Display Vaccination,”
[cited by applicant]
Chen, X. et al., “Fusion Protein Linkers: Property, Design and Functionality,”
[cited by applicant]
Cheng, J. et al., “Cytomegalovirus Infection Causes an Increase of Arterial Blood Pressure,”
[cited by applicant]
Devereux, J. et al., “A comprehensive set of sequence analysis programs for the VAX,”
[cited by applicant]
Hofmann, I. et al., “Expression of the human cytomegalovirus pentamer complex for vaccine use in a CHO system,”
[cited by applicant]
Joyce, M.G. et al., “Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine,”
[cited by applicant]
Karlin, S. et al., “Applications and statistics for multiple high-scoring segments in molecular sequences,”
[cited by applicant]
Kaslow, D.C. et al., “RTS,S: Toward a first landmark on the Malaria Vaccine Technology Roadmap,”
[cited by applicant]
Klein, J.S. et al., “Design and characterization of structured proteinlinkers with differing flexibilities,”
[cited by applicant]
Krarup, A. et al., “A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism,”
[cited by applicant]
Kushnir, N. et al., “Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development,”
[cited by applicant]
Leneghan, D.B. et al., “Nanoassembly routes stimulate conflicting antibody quantity and quality for transmission-blocking malaria vaccines,”
[cited by applicant]
Li, L. et al., “Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide Tag,”
[cited by applicant]
Michel, M. et al., “Optimisation of secretion of recombinant HBsAg virus-like particles: Impact on the development of HIV-1/HBV bivalent vaccines,”
[cited by applicant]
Thrane, S. et al., “Bacterial superglue enables easy development of efficient virus-like particle based vaccines,”
[cited by applicant]
Valenzuela, P. et al., “Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen,”
[cited by applicant]
Veggiani, G. et al., “Superglue from Bacteria: Unbreakable Bridges for Protein Nanotechnology,”
[cited by applicant]
Wang, X. et al., “RT-qPCR-based microneutralization assay for human cytomegalovirus using fibroblasts and epithelial cells,”
[cited by applicant]
Wussow, F. et al., “Human Cytomegalovirus Vaccine Based on the Envelope gH/gL Pentamer Complex,”
[cited by applicant]
Zakeri, B. et al., “Peptide tag forming a rapid covalent bond to a protein, through engineering a bacterial adhesion,”
[cited by applicant]
Search Report in GB Application No. 1807378.3, dated Feb. 1, 2019 (5 pages).
[cited by applicant]
Search Report in GB Application No. 1807376.7, dated Feb. 1, 2019 (5 pages).
[cited by applicant]
International Search Report in International Application No. PCT/GB2019/051245, mailed Oct. 29, 2019 (8 pages).
[cited by applicant]
Pumpens, P. et al., “Construction of Novel Vaccines on the Basis of Virus-Like Particles: Hepatitis B Virus Proteins as Vaccine Carriers,” Ch. 9, pp. 205-248 in
[cited by applicant]
Pushko, P. et al., “Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures,”
[cited by applicant]
Rutgers, T. et al., “Hepatitis B Surface Antigen as Carrier Matrix for the Repetitive Epitope of the Circumsporozoite Protein of
[cited by applicant]
Wikipedia, “SpyCatcher,” available at https://en.wikipedia.org/wiki/SpyCatcher, last accessed Dec. 21, 2022 (8 pages).
[cited by applicant]
Moffat, J.M. et al, “Hepatitis B virus-like particles access major histocompatibility class I and II antigen presentation pathways in primary dendritic cells”, Vaccine, vol. 31, pp. 2310-2316 (Apr. 2013).
[cited by applicant]
Falloon et al., “An Adjuvanted, Postfusion F Protein-Based Vaccine Did Not Prevent Respiratory Syncytial Virus Illness in Older Adults”, The Journal of Infectious Disease, 2017, vol. 216, Issue 11, pp. 1362-1370.
[cited by applicant]
Graham et al., “Novel antigens for RSV vaccines”, Current Opinions in Immunology, 2015, vol. 35, pp. 30-38.
[cited by applicant]
Graham, “Vaccine development for respiratory syncytial virus”, Current Opinions in Virology, 2017, vol. 23, pp. 107-112.
[cited by applicant]
Lilleri et al., “Fetal human cytomegalovirus transmission correlates with delayed maternal antibodies to gH/gL/pUL128-130-131 complex during primary infection”, PLoS One, 2013, vol. 8, Issue 3, Article No. e59863, pp. 1…
[cited by applicant]
Wen et al., “Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice”, Vaccine, 2014, vol. 32, Issue 30, pp. 3796-3804.
[cited by applicant]
Kotiw et al., “Immunological Response to Parenteral Vaccination with Recombinant Hepatitis B Virus Surface Antigen Virus-Like Particles Expressing Helicobacter pylori KatA Epitopes in a Murine H. pylori Challenge Model”…
[cited by applicant]