Quinoline derivatives

1. A compound of formula (I):

wherein

A is A1 or A2,

o is 0, 1, 2, 3 or 4;

R is selected from the group consisting of hydrogen, halogen, cyano, nitro, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl, —S(O)—C 1 -C 4 -halogenoalkyl and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

R p is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl;

X and Y are independently selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 , wherein at least one of X and Y is CR 7 R 8 ; or

X and Y form together a ring member selected from the group consisting of —C(O)—O—, —C(O)—NR 9 —, —S(O)—NR 9 —, —SO 2 —NR 9 — and —SO 2 —O—;

R 1 is selected from the group consisting of hydrogen, cyano, —CHO, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogenocycloalkyl having 1 to 5 halogen atoms, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 -alkyl, —NH—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl) 2 , NH 2 —C 1 -C 2 -alkyl-, C 1 -C 4 -alkyl-NH—C 1 -C 4 -alkyl-, (C 1 -C 4 -alkyl) 2 N—C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl-C(O)— having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C(O)—, benzyloxy-C(O)—, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-C(O)—, —SO 2 —C 1 -C 4 -alkyl, and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms; or

phenyl-C 1 -C 4 -alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl), —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R 2 is selected from the group consisting of tetrahydro-2H-pyran-4-yl, 3,6 dihydro-2H-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl,

R 3 is hydrogen or C 1 -C 4 -alkyl,

R 4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl,

R 5 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl,

R 6 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl,

R 7 is selected from the group consisting of hydrogen, —OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

R 8 is selected from the group consisting of hydrogen, —OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

or R 7 and R 8 together form an oxo group (═O),

or R 7 and R 8 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C 3 -C 6 -cycloalkyl and 3- to 6-membered heterocycloalkyl,

R 9 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy,

R 10 is selected from the group consisting of hydrogen, —OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

R 11 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

or R 10 and R 11 form, together with the carbon atom to which they are attached, a 3- to 6-membered ring selected from the group consisting of C 3 -C 6 -cycloalkyl and 3- to 6-membered heterocycloalkyl,

Q is 2,3,5-trifluorophenyl,

wherein when Y is O, S or N—R 9 , none of R 7 , R 8 , R 10 and R 11 is —OH or C 1 -C 4 -alkoxy, and

wherein when X is O, S or N—R 9 , none of R 7 and R 8 is —OH or C 1 -C 4 -alkoxy,

and wherein a compound according to the formula

is excluded;

or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing.

2. The compound according to claim 1 , wherein:

A is A1 or A2,

o is 0, 1, 2, 3 or 4,

R is selected from the group consisting of hydrogen, halogen, cyano, nitro, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl, —S(O)—C 1 -C 4 -halogenoalkyl and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R p is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl,

X, Y are independently selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 , wherein at least one of X and Y is CR 7 R 8 , or

X, Y form together a ring member selected from the group consisting of —C(O)—O—, —C(O)—NR 9 —, —S(O)NR 9 —, —SO 2 —NR 9 — and —SO 2 —O—,

R 1 is selected from the group consisting of hydrogen, cyano, —CHO, —OH, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halogenocycloalkyl having 1 to 5 halogen atoms, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alky, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 -alkyl, —NH—C 1 -C 4 -alkyl, —N(C 1 -C 4 -alkyl) 2 , NH 2 —C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-NH—C 1 -C 4 -alkyl-, (C 1 -C 4 -alkyl) 2 N—C 1 -C 4 -alkyl-, C 1 -C 4 -alkyl-C(O)—, C 1 -C 4 -halogenoalkyl-C(O)— having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C(O)—, benzyloxy-C(O)—, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl-C(O)—, —SO 2 —C 1 -C 4 -alkyl, and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

phenyl-C 1 -C 4 -alkyl, optionally substituted by 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl), —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms;

heterocyclyl-C 1 -C 4 -alkyl, wherein the heterocyclyl substituent is selected from the group consisting of 4- to 10-membered heterocycloalkyl, 5-membered heteroaryl and 6-membered heteroaryl, each of which is optionally substituted by 1, 2 or 3 substituents independently selected from the group consisting of halogen, —OH, —NO 2 , cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 C 1 -C 4 -alkyl, —S—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, —S(O)—C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and —SO 2 —C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R 2 is selected from the group consisting of tetrahydro-2H-pyran-4-yl, 3,6 dihydro-2H-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl,

R 3 is hydrogen, or C 1 -C 4 -alkyl,

R 4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ,

R 5 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH, —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ,

R 6 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ,

R 7 is selected from the group consisting of hydrogen, —OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

R 8 is selected from the group consisting of hydrogen, —OH, fluorine, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

or R 7 and R 8 together form an oxo group (═O),

R 9 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms and C 1 -C 4 -alkoxy,

R 10 is selected from the group consisting of hydrogen, —OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

R 11 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

Q is 2,3,5-trifluorophenyl,

wherein when Y is O, S or N—R 9 , none of R 7 , R 8 , R 10 and R 11 is —OH or C 1 -C 4 -alkoxy, and wherein when X is O, S or N—R 9 , none of R 7 and R 8 is —OH or C 1 -C 4 -alkoxy,

and wherein a compound according to the formula

is excluded;

or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing.

3. The compound according to claim 1 , wherein:

A is A1 or A2,

o is 0, 1 or 2,

R is selected from the group consisting of halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy, cyano, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms,

R p is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl,

X, Y are independently selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 , wherein at least one of X and Y is CR 7 R 8 ,

R 1 is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl-C 1 -C 3 -alkyl, cyano-C 1 -C 4 -alkyl,

R 2 is selected from the group consisting of tetrahydro-2H-pyran-4-yl, 3,6 dihydro-21-1-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl,

R 3 is hydrogen or C 1 -C 4 -alkyl,

R 4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ,

R 5 is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ,

R 6 is selected from the group consisting of hydrogen, halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 ,

R 7 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl,

R 8 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl,

or R 7 and R 8 together form an oxo group (═O),

R 9 is C 1 -C 4 -alkyl,

R 10 is selected from the group consisting of hydrogen, —OH, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

R 11 is hydrogen,

Q is 2,3,5-trifluorophenyl,

wherein when Y is O, S or N—R 9 , R 10 is not —OH or C 1 -C 4 -alkoxy,

and wherein a compound according to the formula

is excluded;

or a stereoisomer, a tautomer, an N-oxide a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing.

4. The compound according to claim 1 , wherein:

A is A1 or A2,

o is 0, 1 or 2,

R is selected from the group consisting of halogen, C 1 -C 4 -alkyl and C 1 -C 4 -alkoxy,

R p is selected from the group consisting of hydrogen, C 1 -C 4 -alkyl,

X is selected from the group consisting of CR 7 R 8 , O, S, and N—R 9 ,

Y is CR 7 R 8 or O,

R 1 is hydrogen or C 1 -C 4 -alkyl, R 2 is selected from the group consisting of tetrabydro-2H-pyran-4-yl, 3,6 dihydro-2H-1-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl,

R 3 is hydrogen or C 1 -C 4 -alkyl,

R 4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms,

R 5 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy,

R 6 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy,

R 7 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl,

R 8 is selected from the group consisting of hydrogen and C 1 -C 4 -alkyl,

or R 7 and R 8 together form an oxo group (═O),

R 9 is C 1 -C 4 -alkyl,

R 10 is selected from the group consisting of hydrogen, —OH and C 1 -C 4 -alkyl,

R 11 is hydrogen,

Q is 2,3,5-trifluorophenyl,

wherein a compound according to the formula

is excluded;

or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate or a salt thereof or a mixture of the foregoing.

5. The compound according to claim 1 , wherein:

A is selected from the group consisting of

R 1 is hydrogen or methyl,

R 2 is selected from the group consisting of tetrabydro-2H-pyran-4-yl, 3,6 dihydro-2H-1-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl,

R 3 is hydrogen or methyl,

R 4 is selected from the group consisting of hydrogen, fluorine, chlorine, —OH, cyano, methyl, methoxy, trifluoromethyl, trifluoromethoxy and NH 2 ,

R 5 is selected from the group consisting of hydrogen, fluorine, chlorine, —OH, cyano, methyl, methoxy and rifluoromethyl,

R 6 is selected from the group consisting of hydrogen, fluorine, chlorine, —OH, cyano, methyl and methoxy,

Q is 2,3,5-trifluorophenyl,

wherein a compound according to the formula

is excluded;

or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of forgoing.

6. The compound according to claim 1 , wherein:

A is selected from the group consisting of

R 1 is hydrogen or methyl,

R 2 is selected from the group consisting of tetrahydro-2H-pyran-4-yl, 3,6 dihydro-2H-pyran-4-yl, ethyl and 3-fluoroazetidin-1-yl,

R 3 is hydrogen or methyl,

R 4 is selected from the group consisting of hydrogen, chlorine, fluorine, methyl, methoxy, isopropoxy and trifluoromethyl,

R 5 is selected from the group consisting of hydrogen, chlorine, fluorine, —OH, cyano, methyl, trifluoromethoxy and Nit,

R 6 is selected from the group consisting of hydrogen, fluorine, chlorine, —OH, cyano, methyl and methoxy,

Q is 2,3,5-trifluorophenyl,

wherein a compound according to the formula

is excluded;

or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing.

7. The compound according to claim 1 , wherein:

R 2 is tetrahydro-2H-pyran-4-yl,

Q is 2,3,5-trifluorophenyl,

and stereoisomers, tautomers, N-oxides, hydrates, solvates, and salts thereof, and mixtures of the foregoing.

8. The compound according to claim 1 , wherein:

R 2 is 3,6-dihydro-2H-pyran-4-yl,

Q is 2,3,5-trifluorophenyl,

or a stereoisomer, tautomer, N-oxide, hydrate, solvate, and salt thereof, and mixtures of the foregoing.

9. The compound according to claim 1 , wherein:

R 2 is ethyl,

R 4 is selected from the group consisting of hydrogen, halogen, —OH, cyano, C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 4 -halogenoalkyl having 1 to 5 halogen atoms, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -halogenoalkoxy having 1 to 5 halogen atoms, C 1 -C 4 -alkyl-C(O)—, —NH 2 , —NH(C 1 -C 4 -alkyl), —N(C 1 -C 4 -alkyl) 2 , —S—C 1 -C 4 -alkyl, —S(O)—C 1 -C 4 -alkyl, —SO 2 —C 1 -C 4 -alkyl,

Q is 2,3,5-trifluorophenyl,

with the proviso that R 4 is not hydrogen, when A is

and a stereoisomer, tautomer, N-oxide, hydrate, solvate, and salt thereof, and mixtures of the foregoing.

10. The compound according to claim 1 , wherein:

R 2 is 3-fluoroazetidin-1-yl,

Q is 2,3,5-trifluorophenyl,

and a stereoisomer, tautomer, N-oxide, hydrate, solvate, and salt thereof, and mixtures of the foregoing.

11. A method of preparing a compound of formula (I) according to claim 1 , said method comprising the step of reacting an intermediate compound of formula 1N:

wherein A, R 1 , R 3 , R 4 , R 5 , R 6 , and Q are as defined for the compound of formula (I) according to claim 1 ,

with a compound of formula 1F:

R 2 H  1F,

wherein R 2 is 3-fluoroazetidine,

thereby giving a compound of formula (I):

wherein A, R 1 , R 3 , R 4 , R 5 , R 6 , and Q are as defined for the compound of formula (I) according to claim 1 and R 2 is 3-fluoroazetidine,

or the step of reacting an intermediate compound of formula 1T:

wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined for the compound of formula (I) according to claim 1 , and wherein Hal is halogen,

with the proviso that R 4 is not hydrogen when R 2 is ethyl and when A is

with a compound of formula 1H:

Q-B(OR) 2   1H,

wherein Q is 2,3,5-trifluorophenyl, and each R may be individually H or Me or both R are pinacolate,

thereby giving a compound of formula (I):

wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and Q are as defined for the compound of formula (I) according to claim 1 ,

or the step of reacting an intermediate compound of formula 1W:

wherein Q, R 2 , R 3 , R 4 , R 5 and R 6 are as defined for the compound of formula (I) according to claim 1 ,

with the proviso that R 4 is not hydrogen when R 2 is ethyl and when A is

with a compound of formula 1M:

wherein R 1 and A are as defined for the compound of formula (I) according to claim 1 , thereby giving a compound of formula (I):

wherein A, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and Q are as defined for the compound of formula (I) according to claim 1 ,

or the step of reacting an intermediate compound of formula 1N

wherein Q, A, R 1 , R 3 , R 4 , R 5 and R 6 are as defined for the compound of formula (I) according to claim 1 ,

with a compound of formula 2A:

R 2 Met-X  2A,

wherein R 2 is ethyl, or 3,6-dihydro-2H-pyran-4-yl,

with the proviso that R 4 is not hydrogen when R 2 is ethyl and when A is

Met is magnesium or zinc, and X is chlorine, bromine or iodine,

thereby giving a compound of formula (I):

wherein A, R 1 , R 3 , R 4 , R 5 , R 6 , and Q are as defined for the compound of formula (I) according to claim 1 and R 2 is ethyl, or 3,6-dihydro-2H-1pyran-4-yl, with the proviso that R 4 is not hydrogen when R 2 is ethyl and when A is

12. A compound of formula (II):

wherein:

R 2 is —OH or as defined for the compound of formula (I) according to claim 1 ,

R 3 , R 4 , R 5 , R 6 , and Q are as defined for the compound of formula (I) according to claim 1 , and

R A is H or C 1 -C 4 -alkyl,

or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing.

13. A pharmaceutical composition comprising a compound of formula (I) according to claim 1 , or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing, and one or more pharmaceutically acceptable excipients.

14. A method for control, treatment and/or prevention of a disease in humans and/or animals, comprising administering to a human or an animal in need thereof an amount of the compound of formula (I) according to claim 1 , or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the foregoing, wherein the disease is a helminthic infection.

15. A method for controlling helminth infections in humans and/or animals by administering an anthelminthically effective amount of at least one compound of formula (I) according to claim 1 to a human or an animal in need thereof.

16. A method for control, treatment and/or prevention of a disease in humans and/or animals, comprising administering to a human or an animal in need thereof a pharmaceutical composition according to claim 13 , wherein the disease is a helminthic infection.