FLUTICASONE AND VILANTEROL FORMULATION AND INHALER
A composition comprising particulate fluticasone or a pharmaceutically acceptable salt or solvate thereof, particulate vilanterol trifenatate, at least one of 1,1,1,2,3,3,3-heptafluoropropane and 1,1,1,2-tetrafluoroethane.
1 . A composition comprising:
particulate fluticasone or a pharmaceutically acceptable salt or solvate thereof;
particulate vilanterol trifenatate; and
at least one of 1,1,1,2,3,3,3-heptafluoropropane and 1,1,1,2-tetrafluoroethane.
2 . The composition of claim 1 , wherein the fluticasone or a pharmaceutically acceptable salt or solvate thereof is fluticasone furoate.
3 . (canceled)
4 . The composition of claim 1 , wherein the propellant consists essentially of 1,1,1,2,3,3,3-heptafluoropropane.
5 . The composition of claim 1 contained in a canister, wherein the size of the fluticasone particles in the canister is between about 2 micrometers and 4 micrometers.
6 . The composition of claim 1 contained in a canister, wherein the size of the vilanterol trifenatate particles in the canister is between about 1 micrometer and 2 micrometers.
7 - 9 . (canceled)
10 . A composition comprising
particulate fluticasone or a pharmaceutically acceptable salt or solvate thereof;
particulate vilanterol or a pharmaceutically acceptable salt or solvate thereof; and
at least one of 1,1,1,2,3,3,3-heptafluoropropane and 1,1,1,2-tetrafluoroethane, wherein fluticasone and vilanterol or the pharmaceutically acceptable salts or solvates thereof are the only active medicaments in the composition.
11 . The composition of claim 10 , wherein the fluticasone or a pharmaceutically acceptable salt or solvate thereof is fluticasone furoate.
12 . (canceled)
13 . The composition of claim 10 , wherein the propellant consists essentially of 1,1,1,2,3,3,3-heptafluoropropane.
14 . The composition of claim 10 contained in a canister, wherein the size of the fluticasone particles in the canister is between about 2 micrometers and 4 micrometers.
15 . The composition of claim 10 contained in a canister, wherein the size of the vilanterol trifenatate particles in the canister is between about 1 micrometer and 2 micrometers.
16 . (canceled)
19 . The composition of claim 10 , further comprising ethanol.
20 . An aerosol canister comprising a composition of claim 1 .
21 . The aerosol canister of claim 20 comprising at least one surface having a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group disposed thereon, wherein the primer composition has a coating composition comprising an at least partially fluorinated compound disposed thereon.
22 . (canceled)
23 . The aerosol canister of claim 21 , wherein the at least one surface is at least a portion of a valve surface.
24 . An inhaler comprising the composition of claim 1 .
25 . An aerosol canister comprising a composition of claim 10 .
26 . The aerosol canister of claim 25 comprising at least one surface having a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group disposed thereon, wherein the primer composition has a coating composition comprising an at least partially fluorinated compound disposed thereon.
27 . The aerosol canister of claim 26 , wherein the at least partially fluorinated compound is a polyfluoropolyether silane.
28 . An inhaler comprising the composition of claim 10 .
29 . An inhaler comprising the aerosol canister of claim 20 .