Granted Patent
B2
US 11,111,262 · App. 17/063,947 · Granted Sep 7, 2021
C-mannoside compounds useful for the treatment of urinary tract infections
Inventors:
Michael Joseph Bishop (Research Triangle Park, NC); Eugene L. Stewart (Collegeville, PA); Katherine Louisa Widdowson (San Diego, CA); James Walter Janetka (St. Louis, MO); Laurel Kathryn McGrane (St. Louis, MO)
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Abstract
Disclosed herein are new C-mannoside compounds and compositions and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment diseases such as urinary tract infection.
Claims (4)
1. A compound which is
2. A pharmaceutical composition comprising the compound as recited in claim 1 together with a pharmaceutically acceptable carrier.
3. A pharmaceutical composition as recited in claim 2 formulated for oral administration.
4. The pharmaceutical composition as recited in claim 3 , wherein said composition is chosen from a tablet and a capsule.
Assignments (3)
CHANGE OF ADDRESS
Recorded Oct 8, 2025
From: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Reel/Frame 073032/0390 →
CHANGE OF ADDRESS
Recorded Jun 17, 2025
From: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED
Reel/Frame 071649/0432 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 6, 2020
From: BISHOP, MICHAEL JOSEPH; STEWART, EUGENE L.; COLANDREA, VINCENT J.; STRAMBEANU, IULIA; LI, YUEHU; WIDDOWSON, KATHERINE LOUISA; MCGRANE, LAUREL KATHRYN; JANETKA, JAMES WALTER
To: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; FIMBRION THERAPEUTICS, INC.
Reel/Frame 053986/0701 →
Continuity (4)
Continuation
PCTIB2019055806
· Jul 8, 2019
Provisional Application
62695993
· Jul 10, 2018
Provisional Application
62755588
· Nov 5, 2018
Cited By (1)