Compounds comprising tricyclic heterocyclic compounds
The invention relates to a pharmaceutical composition comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and at least one pharmaceutical excipient selected from the group consisting of fillers, binders, disintegrants, glidants and lubricants, wherein the compound according to formula I is represented by:
1. A pharmaceutical composition comprising a succinate salt of a compound, wherein the compound is represented by:
and at least one pharmaceutical excipient selected from the group consisting of fillers, binders, disintegrants, glidants and lubricants.
2. The composition according to claim 1 , further comprising a surfactant in an amount of from 0.1 to 5 wt % based on the total weight of the composition.
3. The composition according to claim 1 , wherein the composition is in the form of a tablet or capsule.
4. The composition according to claim 1 , wherein the composition comprises at least two pharmaceutical excipients.
5. The composition according to claim 1 , wherein the compound is present in an amount of from 5 to 30 wt % based on the total weight of the composition.
6. The composition according to claim 1 , wherein a filler is present in an amount of from 10 to 90 wt % based on the total weight of the composition.
7. The composition according to claim 1 , wherein a binder is present in an amount of from 0.1 to 20 wt % based on the total weight of the composition.
8. The composition according to claim 1 , wherein a disintegrant is present in an amount of from 1 to 20 wt % based on the total weight of the composition.
9. The composition according to claim 1 , wherein a lubricant is present in an amount of from 0.1 to 10 wt % based on the total weight of the composition.
10. The composition according to claim 1 , wherein the composition comprises:
1 to 50 wt % of a compound according to claim 1 ;
10 to 90 wt % of at least one filler;
0.1 to 20 wt % of at least one binder;
1 to 20 wt % of at least one disintegrant; and
0.1 to 10 wt % of at least one lubricant or glidant.
11. The pharmaceutical composition of claim 1 , wherein the pharmaceutical excipient is selected from the group consisting of lactose monohydrate, microcrystalline cellulose, crospovidone, hydroxypropyl cellulose, magnesium stearate, and sodium lauryl sulfate.
12. The pharmaceutical composition of claim 1 , wherein the composition comprises sodium lauryl sulfate, lactose monohydrate, microcrystalline cellulose, crospovidone, hydroxypropyl cellulose, and magnesium stearate.