Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
1. A method of treating acne in a mammalian subject comprising administering to an afflicted body surface of the subject a foam comprising a therapeutically effective amount of a retinoid, wherein the foam is formed from a foamable carrier and a liquified or compressed propellant, the foamable carrier comprising:
i. a dicarboxylic acid ester;
ii. about 0.1% to about 5% by weight of the carrier of at least one surface-active agent;
iii. about 2% to about 50% by weight of the carrier of at least one hydrophobic solvent;
iv. water; and
v. a retinoid,
wherein the foamable carrier does not comprise a polymeric gelling agent.
2. The method of claim 1 , wherein the mammalian subject is a human.
3. The method of claim 2 , wherein the carrier is an emulsion.
4. The method of claim 3 , wherein the dicarboxylic acid ester is about 5% to about 10% by weight of the carrier.
5. The method of claim 4 , wherein the dicarboxylic acid ester is diisopropyl adipate and the at least one hydrophobic solvent is mineral oil.
6. The method of claim 5 , wherein the at least one surface-active agent has a hydrophilic/lipophilic balance (HLB) value of between about 9 and about 14.