IP Library Granted Patent US 11,796,539
Granted Patent B2
US 11,796,539 · App. 17/072,986 · Granted Oct 24, 2023

Systems and methods for determining a characteristic of an emissive species

Inventors: Timothy Manning (Newton, MA); Jason R. Cox (Worcester, MA); Robert Deans (Grafton, MA); Zhengguo Zhu (Chelmsford, MA); Brian E. Fratto (Holden, MA); Gabriel Davis (Aliquippa, PA)
Assignee: C2Sense, Inc.
G01N33/54388C09K11/06G01J5/02G01N21/00G01N21/251G01N21/645G01N21/6408G01N21/6428G01N21/76G01N33/54386G01N33/56983G01N33/582G06K19/14G06V10/141G06V10/143G06V20/80G06V40/1318H04N5/33H04N25/53H04N25/76H10K50/11A61B5/0077A61B5/117C09K2211/1007C09K2211/1029C09K2211/1044C09K2211/1059C09K2211/1092C09K2211/182G01J2005/0077G01N21/21G01N2021/6413G01N2021/6432G01N2021/6439G01N2021/6441G01N2021/6471G01N2021/757G01N2201/062G01N2333/165H10K2101/10
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Quick Facts
Patent No.
US 11,796,539
App. No.
17/072,986
Granted
Oct 24, 2023
Kind
B2
Abstract

Embodiments described herein generally relate to: sensing and/or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and/or to emissive species, such as those excitable by white light, and related systems and methods.

Claims (35)

1. A system, comprising:

a radiation source configured to generate electromagnetic radiation for exciting an emissive species such that the emissive species produces a detectable non-steady-state emission during an emission time period of the emissive species, the emission time period being at least 10 nanoseconds;

a sensor configured to:

detect, during a first portion of the emission time period, a first emission from the emissive species, and

detect, during a second portion of the emission time period, a second emission from the emissive species; and

processing circuitry configured to identify a characteristic of the emissive species based on a difference between a property of the first emission detected during the first portion of the emission time period and a property of the second emission detected during the second portion of the emission time period.

2. A system as in claim 1 , wherein the radiation source, or a second radiation source, is configured to generate electromagnetic radiation for exciting the emissive species such that the emissive species produces a detectable steady-state emission.

3. A system as in claim 1 , wherein the radiation source, or a second radiation source, is configured to generate electromagnetic radiation for exciting a second emissive species such that the second emissive species produces a detectable steady-state emission.

4. A system as in claim 3 , wherein the sensor is configured to detect, during a first portion of the second emission time period, a first emission from the second emissive species, and to detect, during a second portion of the second emission time period, a second emission from the second emissive species.

5. A system as in claim 3 , wherein each emissive species is the same.

6. A system as in claim 3 , wherein the system comprises a plurality of emissive species.

7. The system of claim 3 , wherein the characteristic of the emissive species corresponds to the presence or absence of an analyte.

8. The system of claim 3 , wherein the characteristic corresponds to exposure of the emissive species to temperature, thermal history, pH, UV radiation, humidity, a sterilization technique(s), a chemical(s), a pathogen(s), a biological species, and/or mechanical stress.

9. A system as in claim 3 , further comprising a source of colorimetric signals.

10. A system as in claim 9 , wherein the colorimetric signal is associated with including images of the assay cartridge, markers that may be used for alignment, text, numbers, pictures, logos, bar codes, and/or QR codes.

11. A system as in claim 1 , wherein the radiation source is configured to generate electromagnetic radiation for exciting a second emissive species such that the second emissive species produces a second detectable non-steady-state emission during a second emission time period, the second emission time period being at least 10 nanoseconds.

12. The system of claim 1 , wherein the emission time period is less than 100 milliseconds.

13. The system of claim 1 , wherein the emission time period is less than 10 microseconds.

14. The system of claim 1 , wherein the emission time period is less than 0.1 microseconds.

15. The system of claim 1 , further comprising an article associated with the emissive species, wherein the characteristic of the emissive species corresponds to a characteristic of the article.

16. A system comprising:

a radiation source configured to generate electromagnetic radiation for exciting an emissive species such that the emissive species produces a detectable non-steady-state emission during an emission time period of the emissive species;

an electromagnetic radiation sensor configured to sense during a single exposure:

first emission from the emissive species during a first portion of the emission time period, and

second emission from the emissive species during a second portion of the emission time period; and

processing circuitry configured to identify a characteristic of the emissive species based on a difference between a property of the first emissions detected during the first portion of the emission time period and a property of the second emissions detected during the second portion of the emission time period.

17. A system as in claim 16 , wherein the second emission is a steady-state emission of the emissive species.

18. A system as in claim 16 , wherein the radiation source, or a second radiation source, is configured to generate electromagnetic radiation for exciting a second emissive species such that the second emissive species produces a detectable steady-state emission during an emission time period of the second emissive species.

19. A system as in claim 16 , wherein the processing circuitry is configured to identify a characteristic of the emissive species based on a difference between a property of the non-steady-state emissions and a property of the steady-state emissions.

20. A method for identifying a characteristic of an emissive species, comprising:

generating electromagnetic radiation;

exciting, using the electromagnetic radiation, an emissive species such that the emissive species produces a detectable non-steady-state emission during an emission time period of the emissive species;

detecting, during a first portion of the emission time period, a first emission from the emissive species, and

detecting, during a second portion of the emission time period, a second emission from the emissive species; and

identifying, using processing circuitry, the characteristic of the emissive species based on a difference between a property of the first emission detected during the first portion of the emission time period and a property of the second emission detected during the second portion of the emission time period.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 23, 2021
From: SWAGER, TIMOTHY MANNING; COX, JASON R.; DEANS, ROBERT; ZHU, ZHENGGUO; FRATTO, BRIAN E.; DAVIS, GABRIEL
To: C2SENSE, INC.
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