IP Library Granted Patent US 11,439,339
Granted Patent B1
US 11,439,339 · App. 17/073,230 · Granted Sep 13, 2022

Method and system for measuring cardiac tissue health based on DV/DT

Inventor: Robert L. Lux (Park City, UT)
Assignee: NEUCURES INC.
A61B5/349
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Quick Facts
Patent No.
US 11,439,339
App. No.
17/073,230
Granted
Sep 13, 2022
Kind
B1
Abstract

A method for determining cardiac tissue health based on a depolarization wave within an EGM is disclosed. The method includes computing a first derivative with respect to time (DV/DT) of the EGM, determining extrema for the first derivative, establishing a value DV/DT MIN based on the extrema and mapping the value DV/DT MIN to cardiac tissue.

Claims (38)

1. A method for determining cardiac tissue health based on a depolarization wave within an electrogram (EGM), comprising:

receiving, by a processor, an electrogram (EGM), wherein the EGM comprises at least one of a unipolar EGM and a bipolar EGM;

removing, by the processor, noise from the EGM when the noise is above a predefined threshold;

computing, by the processor, a first derivative with respect to time (DV/DT) of the EGM;

determining, by the processor, extrema for the first derivative, wherein the extrema comprises at least a maxima and a minima;

based on the extrema, establishing, by the processor, a value DV/DT MIN by selecting at least one of

the minima as the value for DV/DT MIN for the unipolar EGM;

the maxima and the minima for the bipolar EGM as the value for DV/DT MIN based on a ratio; and

mapping, by the processor, the value DV/DT MIN to cardiac tissue.

2. The method of claim 1 , wherein the value for DV/DT MIN for the bipolar EGM is selected as Min dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is greater than or equal to one.

3. The method of claim 1 , wherein the value for DV/DT MIN for the bipolar EGM is selected as the −Max dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is less than one.

4. The method of claim 1 , wherein the noise is removed by applying a power line filter or a random noise filter to the EGM.

5. A system for determining cardiac tissue health based on a depolarization wave within an electrogram (EGM), comprising:

a memory; and

one or more processors coupled to the memory programmed with executable instructions to:

receive an electrogram (EGM), wherein the EGM comprises at least one of a unipolar EGM and a bipolar EGM;

remove noise from the EGM when the noise is above a predefined threshold;

compute a first derivative with respect to time (DV/DT) of the EGM;

determine extrema for the first derivative, wherein the extrema comprise at least a maxima and a minima;

based on the extrema, establish a value DV/DT MIN by selecting at least one of

the minima as the value for DV/DT MIN for the unipolar EGM;

the maxima and the minima for the bipolar EGM as the value for DV/DT MIN based on a ratio; and

map the value DV/DT MIN to cardiac tissue.

6. The system of claim 5 , wherein the value for DV/DT MIN for the bipolar EGM is selected as Min dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is greater than or equal to one.

7. The system of claim 5 , wherein the value for DV/DT MIN for the bipolar EGM is selected as the −Max dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is less than one.

8. The system of claim 5 , wherein the noise is removed by applying a power line filter or a random noise filter to the EGM.

9. A non-transitory computer readable storage medium, having stored thereon, a set of computer-executable instructions that causes a computer to perform the method comprising:

receiving an electrogram (EGM), wherein the EGM comprises at least one of a unipolar EGM and a bipolar EGM;

removing noise from the EGM when the noise is above a predefined threshold;

computing a first derivative with respect to time (DV/DT) of the EGM;

determining extrema for the first derivative, wherein the extrema comprise at least a maxima and a minima;

based on the extrema, establishing a value DV/DT MIN by selecting at least one of

the minima as the value for DV/DT MIN for the unipolar EGM;

the maxima and the minima for the bipolar EGM as the value for DV/DT MIN based on a ratio; and

mapping the value DV/DT MIN to cardiac tissue.

10. The non-transitory computer readable storage medium of claim 9 , wherein the value for DV/DT MIN for the bipolar EGM is selected as Min dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is greater than or equal to one.

11. The non-transitory computer readable storage medium of claim 9 , wherein the value for DV/DT MIN for the bipolar EGM is selected as the −Max dV/dt when the ratio |Min dV/dt|/|Max dV/dt| is less than one.

12. The non-transitory computer readable storage medium of claim 9 , wherein the noise is removed by applying a power line filter or a random noise filter to the EGM.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2024
From: NEUTRACE INC.
To: ANUMANA, INC.
Reel/Frame 069433/0461 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2023
From: NEUCURES INC
To: NEUTRACE INC.
Reel/Frame 062745/0061 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 22, 2020
From: LUX, ROBERT L.
To: NEUCURES INC.
Reel/Frame 054144/0779 →
Cited By (3)
US 12,303,281 US 12,350,057 US 12,433,526