Crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane and methods of making and using the same
Aspects of the disclosure include crystalline solids of 3-palmitoyl-amido-1,2-propanediol and 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane. Methods for preparing the crystalline solids of 3-palmitoyl-amido-1,2-propanediol and single crystals of 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane are also provided. Methods for preparing a 3-palmitoyl-amido-2-hydroxy-1-dimethoxytriphenylmethylether-propane from a crystalline solid of 3-palmitoyl-amido-1,2-propanediol are also described.
1. A crystalline solid of a compound of Formula I:
having an XRPD pattern comprising peaks at about 2.75° 2Θ; about 6° 2Θ; about 3.8° 2Θ; about 8.25° 2Θ; about 15° 2Θ; about 26.3° 2Θ; about 30.5° 2Θ and about 33.1° 2Θ.
2. The crystalline solid of claim 1 , having a first endotherm at 79.3° C. and a second endotherm at about 102.5° C. by differential scanning calorimetry (DSC).
3. The crystalline solid of claim 1 , wherein thermogravimetric analysis (TGA) of the crystalline solid is characterized by a single weight loss step that begins at about 200.5° C.
4. The crystalline solid of claim 2 , wherein the second endotherm is a single peak endotherm.