Analysis apparatus and analysis program
An analysis apparatus according to an embodiment includes an extraction unit, a calculation unit, and an evaluation unit. The extraction unit extracts a detection value in a tumor region, a blood region, and a muscle region from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor. The calculation unit calculates a first comparison value that is a comparison result between the detection value in the blood region and the detection value in the tumor region, and a second comparison value that is a comparison result between the detection value in the muscle region and the detection value in the tumor region. The evaluation unit evaluates an accumulation of the drug in the tumor, based on the first comparison value and the second comparison value calculated by the calculation unit.
1. An analysis apparatus, comprising:
processing circuitry configured to
extract first, second, and third detection values in a tumor region, a blood region, and a muscle region, respectively, from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor;
calculate a first comparison value that is a comparison result between the second detection value in the blood region and the first detection value in the tumor region; and a second comparison value that is a comparison result between the third detection value in the muscle region and the first detection value in the tumor region; and
evaluate a specificity of accumulation of the drug in the tumor, based on the first comparison value and the second comparison value, wherein the specificity of accumulation of the drug in the tumor is evaluated based on (1) a first comparison result between the first comparison value and a threshold, and (2) a second comparison result between the second comparison value and the threshold.
2. The analysis apparatus according to claim 1 , wherein the first comparison value is a ratio between the second detection value in the blood region and the first detection value in the tumor region.
3. The analysis apparatus according to claim 1 , wherein the second comparison value is a ratio between the third detection value in the muscle region and the first detection value in the tumor region.
4. The analysis apparatus according to claim 1 , wherein the processing circuitry is further configured to evaluate the specificity of the accumulation of [ 18 F]5-FU in the tumor.
5. The analysis apparatus according to claim 1 , wherein the processing circuitry is further configured to (1) evaluate that the drug is easily accumulated in the tumor when the first comparison value and the second comparison value are both greater than the threshold, and (2) evaluate that the drug is not easily accumulated in the tumor when at least one of the first comparison value and the second comparison value is smaller than the threshold.
6. The analysis apparatus according to claim 1 , wherein the processing circuitry is further configured to (1) evaluate that the drug is easily accumulated in the tumor when the first comparison value and the second comparison value are both greater than the threshold, (2) evaluate that the drug is moderately accumulated in the tumor when one of the first comparison value and the second comparison value is smaller than the threshold, and (3) evaluate that the drug is not easily accumulated in the tumor when both of the first comparison value and the second comparison value are smaller than the threshold.
7. A non-transitory computer-readable medium having stored thereon instructions that, when executed by a computer, cause the computer to perform:
extracting first, second, and third detection values in a tumor region, a blood region, and a muscle region, respectively, from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor;
calculating a first comparison value that is a comparison result between the second detection value in the blood region and the first detection value in the tumor region, and a second comparison value that is a comparison result between the third detection value in the muscle region and the first detection value in the tumor region; and
evaluating a specificity of accumulation of the drug in the tumor, based on the first comparison value and the second comparison value, wherein the specificity of accumulation of the drug in the tumor is evaluated based on (1) a first comparison result between the first comparison value and a threshold, and (2) a second comparison result between the second comparison value and the threshold.
8. The non-transitory computer readable medium according to claim 7 , wherein the instructions further cause the computer to evaluate the specificity of the accumulation of [ 18 F]5-FU in the tumor.
9. The non-transitory computer readable medium according to claim 7 , wherein the instructions further cause the computer to (1) evaluate that the drug is easily accumulated in the tumor when the first comparison value and the second comparison value are both greater than the threshold, and (2) evaluate that the drug is not easily accumulated in the tumor when at least one of the first comparison value and the second comparison value is smaller than the threshold.
10. The non-transitory computer readable medium according to claim 7 , wherein the instructions further cause the computer to (1) evaluate that the drug is easily accumulated in the tumor when the first comparison value and the second comparison value are both greater than the threshold, (2) evaluate that the drug is moderately accumulated in the tumor when one of the first comparison value and the second comparison value is smaller than the threshold, and (3) evaluate that the drug is not easily accumulated in the tumor when both of the first comparison value and the second comparison value are smaller than the threshold.
11. An analysis method executed by a computer, comprising:
extracting first, second, and third detection values in a tumor region, a blood region, and a muscle region, respectively, from a nuclear medicine image of a subject administered with a drug containing a radiolabeled anticancer drug that works by accumulating in a tumor;
calculating a first comparison value that is a comparison result between the second detection value in the blood region and the first detection value in the tumor region, and a second comparison value that is a comparison result between the third detection value in the muscle region and the first detection value in the tumor region; and
evaluating a specificity of accumulation of the drug in the tumor, based on the first comparison value and the second comparison value, wherein the specificity of accumulation of the drug in the tumor is evaluated based on (1) a first comparison result between the first comparison value and a threshold, and (2) a second comparison result between the second comparison value and the threshold.
12. The analysis method according to claim 11 , wherein the first comparison value is a ratio between the second detection value in the blood region and the first detection value in the tumor region.
13. The analysis method according to claim 11 , wherein the second comparison value is a ratio between the third detection value in the muscle region and the first detection value in the tumor region.
14. The analysis method according to claim 11 , wherein evaluating the specificity comprises evaluating the specificity of the accumulation of [ 18 F]5-FU in the tumor.
15. The analysis method according to claim 11 , wherein evaluating the specificity comprises (1) evaluating that the drug is easily accumulated in the tumor when the first comparison value and the second comparison value are both greater than the threshold, and (2) evaluating that the drug is not easily accumulated in the tumor when at least one of the first comparison value and the second comparison value is smaller than the threshold.
16. The analysis method according to claim 11 , wherein evaluating the specificity comprises (1) evaluating that the drug is easily accumulated in the tumor when the first comparison value and the second comparison value are both greater than the threshold, (2) evaluating that the drug is moderately accumulated in the tumor when one of the first comparison value and the second comparison value is smaller than the threshold, and (3) evaluating that the drug is not easily accumulated in the tumor when both of the first comparison value and the second comparison value are smaller than the threshold.