Compositions comprising (R)-2-amino-3-phenylpropyl carbamate and uses thereof
View Patent ↗The present invention relates to a newly identified solvate form of (R)-2-amino-3-phenylpropyl carbamate (APC) hydrochloride, a method of preparing APC hydrochloride, and methods of using the same to treat disorders. The invention further relates to methods of producing APC hydrochloride with increased purity.
1. A composition comprising (R)-2-amino-3-phenylpropyl carbamate hydrochloride and 2-chloropropane, wherein the composition comprises less than about 5 ppm 2-chloropropane.
2. The composition of claim 1 , wherein the composition comprises less than about 1 ppm 2-chloropropane.
3. The composition of claim 1 , wherein the composition is a dosage form.
4. The composition of claim 3 , wherein the composition is an immediate release oral dosage form.
5. The composition of claim 4 , wherein the composition is a tablet or a capsule.
6. A method of treating narcolepsy, cataplexy, excessive daytime sleepiness, drug addiction, sexual dysfunction, fatigue, fibromyalgia, attention deficit/hyperactivity disorder, restless legs syndrome, depression, bipolar disorder, or obesity in a subject in need thereof, or promoting smoking cessation in a subject in need thereof, comprising administering to the subject the composition of claim 1 .
7. The method of claim 6 , wherein the composition is administered once per day.
8. The method of claim 6 , wherein the composition is administered more than once per day.