Wound dressing materials and methods of making thereof
Disclosed is a wound dressing material comprising a substrate, about 2.5% to about 8% by weight of a bicarbonate, and a film-forming agent, the film-forming agent serving as a binder for said bicarbonate to said substrate, the film-forming agent and the bicarbonate being present in a ratio of between 1:2 and 2:1 with respect to one another. Also disclosed are a method for preparing a wound dressing material and a method for treating a wound.
1. A wound dressing material comprising a substrate, greater than 2% by weight of a bicarbonate, and a film-forming agent, said film-forming agent serving as a binder for said bicarbonate to said substrate, the film-forming agent and the bicarbonate being present in a ratio of between 1:2 and 2:1 with respect to one another.
2. A wound dressing material according to claim 1 , said bicarbonate comprising sodium bicarbonate.
3. The wound dressing material of claim 2 , said substrate comprising a cellulosic material.
4. The wound dressing material of claim 3 , said substrate further comprising a polyester.
5. The wound dressing material of claim 1 , wherein the film forming agent comprises a polysaccharide, chitosan, povidone, gelatin, a polyethylene glycol, hydroxyethylcellulose, hypromellose, a polymethacrylate, poly(methyl vinyl ether/maleic anhydride), shellac, or combinations thereof.
6. The wound dressing material of claim 1 , wherein the film forming agent is a polyethylene glycol having a molecular weight of about 1,000 to about 10,000.
7. The wound dressing material of claim 1 , further including a plasticizer.
8. The wound dressing material of claim 7 , wherein the plasticizer comprises glycerin.
9. The wound dressing material of claim 1 , wherein the wound dressing further includes at least one of a buffering agent, anti-microbial agent, and a nutritive agent.
10. A method of making a wound dressing material, the method comprising:
providing a substrate;
applying an aqueous wound dressing composition to the substrate, said composition comprising a bicarbonate and a film-forming agent, the bicarbonate and the film forming agent being present in the wound dressing composition at a ratio of from 1:2 to 2:1 relative to each other; and
drying the at least a part of the wound dressing material having the at least a portion of the wound dressing solution composition applied thereto to yield a wound dressing material that includes greater than 2% by weight of said bicarbonate.
11. A method according to claim 10 , said bicarbonate comprising sodium bicarbonate.
12. A method according to claim 11 , said substrate comprising a cellulosic material.
13. A method according to claim 12 , said substrate further comprising a polyester.
14. A method according to claim 10 , wherein the film forming agent comprises a polysaccharide, chitosan, povidone, gelatin, a polyethylene glycol, hydroxyethylcellulose, hypromellose, a polymethacrylate, poly(methyl vinyl ether/maleic anhydride), shellac, or combinations thereof.
15. A method according to claim 10 , wherein the film forming agent is a polyethylene glycol having a molecular weight of about 1,000 to about 10,000.
16. A method according to claim 10 , the composition further including a plasticizer.
17. A method according to claim 16 , wherein the plasticizer comprises glycerin.
18. A method according to claim 10 , wherein the composition further includes at least one of a buffering agent, anti-microbial agent, and nutritive agent.
19. The method of claim 10 , further comprising pressing out at least some of the composition from the wound dressing.
20. The method of claim 10 , further comprising applying backing to the wound dressing material.
21. A method of treating a wound, comprising applying a wound dressing material, said wound dressing material comprising a substrate, greater than 2% by weight of a bicarbonate, and a film-forming agent, said film-forming agent serving as a binder for said bicarbonate to said substrate, the film-forming agent and the bicarbonate being present in a ratio of between 1:2 and 2:1 with respect to one another.