Detachable and retrievable stents for therapeutic agent delivery

1. A system for treating a medical condition, the system comprising:

a stent having proximal and distal regions, and further having a delivery state and an expanded state;

a therapeutic agent disposed on a segment of the stent;

a core assembly having proximal and distal regions, wherein the stent is disposed around an exterior surface of the core assembly in the delivery state; and

a coupling assembly that releasably secures the proximal region of the stent to the exterior surface of the core assembly,

wherein the coupling assembly secures the stent to the core assembly for a predetermined period while the stent is in the expanded state and during release of the therapeutic agent at a target site, and

wherein the coupling assembly further enables the stent to be disengaged from the core assembly and deployed in a bodily passageway,

wherein the coupling assembly comprises a coiled portion extending from the proximal region of the stent, and further comprises a retaining portion disposed on the core assembly, wherein the coiled portion selectively interlocks with the retaining portion,

wherein the coiled portion has a proximal and distal end, and a plurality of helical turns disposed between the proximal and distal ends, and the plurality of helical turns are in a zone of the selective interlock.

2. The system of claim 1 , wherein the stent comprises a proximal taper, a distal taper, and a central region extending therebetween, and further comprises a plurality of members extending axially with a plurality of slots disposed between the plurality of members, wherein the plurality of slots permit perfusion distal to a treatment site when the stent is in the expanded state.

3. The system of claim 1 , wherein the coupling assembly further enables recapture of the stent after deployment inside of the bodily passageway.

4. The system of claim 1 , wherein the coupling assembly is integrally formed with the proximal region of the stent.

5. The system of claim 1 , wherein the core assembly comprises a guidewire lumen.

6. The system of claim 1 , wherein the stent comprises a self-expanding material.

7. The system of claim 1 , further comprising a balloon coupled to the exterior surface of the core assembly that permits expansion of the stent from the delivery state to the expanded state.

8. A method for treating a medical condition, the method comprising:

providing a stent having proximal and distal regions, and further having a delivery state and an expanded state, wherein a therapeutic agent is disposed on a segment of the stent;

delivering the stent to a target site while disposed around an exterior surface of a core assembly, where a coupling assembly releasably secures the proximal region of the stent to the exterior surface of the core assembly during delivery;

expanding the stent to the expanded state, wherein the coupling assembly secures the stent to the core assembly for a predetermined period while the stent is in the expanded state and during release of the therapeutic agent at a target site, and

actuating the coupling assembly to fully disengage the stent from the core assembly to deploy the stent in a bodily passageway; and

using the coupling assembly to recapture the stent after deployment inside of the bodily passageway.

9. The method of claim 8 , wherein the stent comprises a proximal taper, a distal taper, and a central region extending therebetween, and further comprises a plurality of members extending axially with a plurality of slots disposed between the plurality of members, wherein the plurality of slots permit perfusion distal to a treatment site when the stent is in the expanded state.

10. The method of claim 8 , where the coupling assembly comprises a coiled portion extending from the proximal region of the stent, and further comprises a retaining portion disposed on the core assembly, wherein the coiled portion selectively interlocks with the retaining portion.

11. A system for treating a medical condition, the system comprising:

an expandable structure having proximal and distal regions, a central region disposed therebetween, and further having a delivery state and an expanded state;

a core assembly having proximal and distal regions, wherein the expandable structure is disposed around an exterior surface of the core assembly in the delivery state; and

a coupling assembly that releasably secures the proximal region of the expandable structure to the exterior surface of the core assembly,

wherein the coupling assembly further enables the expandable structure to be disengaged from the core assembly and deployed in a bodily passageway,

wherein the coupling assembly comprises a coiled portion extending from the proximal region of the expandable structure, and further comprises a retaining portion disposed on the core assembly, wherein the coiled portion selectively interlocks with the retaining portion,

wherein the expandable structure further comprises a proximal taper disposed distal to the coiled portion, wherein the proximal taper transitions to the central region, and wherein the distal region of the expandable structure is flared and comprises a larger outer diameter in the expanded state compared to the proximal region,

wherein the central region of the expandable structure comprises a plurality of axially-extending members, wherein each of the axially-extending members comprises proximal and distal ends, and each of the proximal ends of the axially-extending members are disposed closer to the coupling assembly relative to a respective distal end of the axially-extending members, and wherein the plurality of axially-extending members are separated by a plurality of slots that permit perfusion distal to a treatment site when the expandable structure is in the expanded state.

12. The system of claim 11 , wherein a therapeutic agent is disposed on a segment of the expandable structure, and wherein the coupling assembly secures the expandable structure to the core assembly for a predetermined period while the expandable structure is in the expanded state and during release of the therapeutic agent at a target site.

13. The system of claim 11 , wherein the expandable structure is a stent.

14. The system of claim 11 , wherein the coiled portion has a proximal and distal end, and a plurality of helical turns disposed between the proximal and distal ends, and the plurality of helical turns are in a zone of the selective interlock.

15. The system of claim 11 , wherein the coupling assembly further enables recapture of the expandable structure after deployment inside of the bodily passageway.

16. The system of claim 11 , wherein the coiled portion is integrally formed with the proximal region of the stent.

17. The system of claim 11 , wherein the core assembly comprises a guidewire lumen.

18. The system of claim 11 , wherein the expandable structure comprises a self-expanding material.

19. The system of claim 11 , further comprising a balloon coupled to the exterior surface of the core assembly that permits expansion of the expandable structure from the delivery state to the expanded state.