Granted Patent B2

US 12,377,222 · App. 17/100,021 · Granted Aug 5, 2025

Inventors: Stephanie Mangold (Schornsheim, DE); Raymond Moser (Engelburg, CH)

Assignee: SCHOTT Pharma AG & Co. KGaA

A61M5/3129C10M107/50A61M2005/3131C10M2229/025C10N2040/50

Abstract

Claims (72)

1. A receptacle for pharmaceutical packaging, comprising:

an elongate barrel section, the elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p is determined along the axis, the elongate barrel section extends from an axial position pA to an axial position pB, wherein pA is a first axial terminal end position of the elongate barrel section and pB is a second axial terminal end position of the elongate barrel section that is opposite the first axial terminal end position and an elongate barrel section length LB is a distance between pA and pB;

a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter; and

a layer of a lubricant located on at least a part of the inner surface; at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p; a portion X of the axis extends from an axial position p 1 to an axial position p 2 such that the following criteria are satisfied:

i. both p 1 and p 2 lie between pA and pB,

ii. a portion length LX is a distance between p 1 and p 2 ,

iii. LX is at least 60% of the length LB,

iv. the layer extends over the entire portion X, and

v. a thickness t 1 of the layer at the axial position p 1 is less than a thickness t 2 of the layer at the axial position p 2 , wherein the thickness of the layer increases monotonically over the entire portion X from p 1 to p 2 ;

wherein at least one criteria is satisfied and is selected from the group consisting of:

the length LB is in a range from 3 cm to 20 cm;

a mean value of the diameter of the interior determined over a range pA to pB is in a range from 0.4 cm to 4 cm;

a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm; and

a volume of the interior is in a range from 0.1 ml to 150 ml.

2. The receptacle of claim 1 , wherein a ratio of the thicknesses t 1 :t 2 is in a range from 1:1.1 to 1:100.

3. The receptacle of claim 2 , wherein the ratio of the thicknesses t 1 :t 2 is in a range from 1:15 to 1:70.

4. The receptacle of claim 1 , wherein the lubricant comprises one or more silicone oils.

5. The receptacle of claim 4 , wherein the one or more silicone oils are at least partially contained in a matrix.

6. The receptacle of claim 1 , wherein the interior is cylindrical or truncated conical over the elongate barrel section.

7. The receptacle of claim 1 , further comprising a first aperture at a first end and a second aperture at a second end.

8. The receptacle of claim 1 , wherein the diameter of the interior at p 1 is d 1 and the diameter of the interior at p 2 is d 2 and d 1 is greater than d 2 .

9. The receptacle of claim 1 , further comprising an aperture and an attachment element at the aperture.

10. The receptacle of claim 1 , wherein the layer has a minimum thickness tmin determined in the portion X of at least 60 nm.

11. The receptacle of claim 1 , wherein the thickness t 2 of the layer at p 2 is at least 100 nm greater than the thickness t 1 of the layer at p 1 .

12. The receptacle of claim 1 , wherein the layer has a minimum thickness tmin determined between p 1 and p 2 inclusive that is greater than a mean roughness of the inner surface of the side wall between p 1 and p 2 .

13. The receptacle of claim 1 , wherein the portion X is split into n sections of equal length M 1 to M n ; the sections M 1 to M n are ordered, with section M 1 starting at p 1 and section M n finishing at p 2 ; mean values of layer thickness over the sections M 1 to M n are T 1 to T n respectively; each mean layer thickness T through the series T 2 to T n is greater than the preceding mean value of T:T 1 to T n-1 respectively; and n is an integer of 2 or more.

14. The receptacle of claim 1 , wherein LX is at least 80% of the length LB.

15. A kit, comprising:

a receptacle, the receptacle comprising:

an elongate barrel section, the elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p is determined along the axis, the elongate barrel section extends from an axial position pA to an axial position pB, wherein pA is a first axial terminal end position of the elongate barrel section and pB is a second axial terminal end position of the elongate barrel section that is opposite the first axial terminal end position and an elongate barrel section length LB is a distance between pA and pB;

a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter; and

a layer of a lubricant located on at least a part of the inner surface; at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p; a portion X of the axis extends from an axial position p 1 to an axial position p 2 such that the following criteria are satisfied:

both p 1 and p 2 lie between pA and pB,

a portion length LX is a distance between p 1 and p 2 ,

LX is at least 60% of the length LB,

the layer extends over the entire portion X, and

a thickness t 1 of the layer at p 1 is less than a thickness t 2 of the layer at p 2 , wherein the thickness of the layer increases monotonically over the entire portion X from p 1 to p 2 ;

wherein at least one criteria is satisfied and is selected from the group consisting of:

the length LB is in a range from 3 cm to 20 cm;

a mean value of the diameter of the interior determined over a range pA to pB is in a range from 0.4 cm to 4 cm;

a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm; and

a volume of the interior is in a range from 0.1 ml to 150 ml; and

a charge that is adapted and arranged to be positioned in the interior such that:

i. the charge seals a cross section of the interior between the inner surface of the side wall and another inner surface of a second side wall;

ii. the charge has a front end at an axial position closest to pB at which the charge contacts the layer or the inner surface;

iii the charge has a back end at an axial position closest to pA at which the charge contacts the layer or the inner surface;

iv a length of the charge LC is a distance between the front end and the back end;

v. the charge has a charge axial position, being the axial position of the front end; and

vi. the charge is movable in a direction parallel to the axis with a stiction s, the stiction s being a function of the charge axial position.

16. The kit of claim 15 , wherein, for charge axial positions in a range from p 1 +LC to p 2 , the stiction s has a maximum value smax, a minimum value smin and the value of smin/smax is 70% or more.

17. The kit of claim 15 , wherein the stiction s at a charge axial position p 2 is equal to or less than the stiction s at a charge axial position p 1 +LC.

18. The kit of claim 15 , wherein the stiction s reduces monotonically from p 1 +LC to p 2 .

19. An assembly, comprising:

a receptacle, the receptacle comprising:

an elongate barrel section, the elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p is determined along the axis, the elongate barrel section extends from an axial position pA to an axial position pB, wherein pA is a first axial terminal end position of the elongate barrel section and pB is a second axial terminal end position of the elongate barrel section that is opposite the first axial terminal end position and an elongate barrel section length LB is a distance between pA and pB;

a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter; and

a layer of a lubricant located on at least a part of the inner surface; at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p; a portion X of the axis extends from an axial position p 1 to an axial position p 2 such that the following criteria are satisfied:

both p 1 and p 2 lie between pA and pB,

a portion length LX is a distance between p 1 and p 2 ,

LX is at least 60% of the length LB,

the layer extends over the entire portion X, and

a thickness t 1 of the layer at p 1 is less than a thickness t 2 of the layer at p 2 , wherein the thickness of the layer increases monotonically over the entire portion X from p 1 to p 2 ;

wherein at least one criteria is satisfied and is selected from the group consisting of:

the length LB is in a range from 3 cm to 20 cm;

a mean value of the diameter of the interior determined over a range pA to pB is in a range from 0.4 cm to 4 cm;

a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm; and

a charge, wherein:

a. the receptacle has an aperture;

b. the charge is positioned in the interior sealing a cross section of the interior;

c. the interior contains a liquid pharmaceutical composition, located between the sealed cross section and the aperture; and

d. the assembly is adapted and arranged for the liquid pharmaceutical composition to be ejected through the aperture by movement of the charge in a direction parallel to the axis.

20. The assembly of claim 19 , wherein the charge is movable in a direction parallel to the axis with a stiction s, the stiction s being a function of an axial position of the charge, the charge defining a length of the charge LC that is a distance between a front end and a back end of the charge, the stiction s reducing monotonically from p 1 +LC to p 2 .

Assignments (2)

Priority Claims (2)

Continuity (1)

References Cited (19)