Methods and compositions of preventing and treating dental caries
Provided herein are methods and compositions related to bacteria of genus Rothia useful as therapeutic agents for dental caries.
1. A method of treating or reducing severity of dental caries in a subject comprising administering to the subject a therapeutically effective amount of a bacterial composition comprising a bacterium of species Rothia denticariosa , a bacterium of species Rothia aeria , or a combination thereof.
2. The method of claim 1 , wherein the bacterial composition treats or reduces severity of dental caries by inhibiting acid production by a cariogenic bacterium.
3. The method of claim 1 , wherein the bacterial composition does not inhibit growth of a cariogenic bacterium.
4. The method of claim 1 , wherein the cariogenic bacterium is a bacterium of species Streptococcus mutans, Streptococcus infantis, Streptococcus sanguinis SK36, or Streptococcus sobrinus.
5. The method of claim 4 , wherein the bacterium of species Streptococcus mutans is a bacterium of strain ATCC UA140 or ATCC UA159.
6. The method of claim 1 , wherein the cariogenic bacterium is a bacterium of genus Lactobacillus.
7. The method of claim 6 , wherein the bacterium of genus Lactobacillus is a bacterium of species Lactobacillus fermentum and Lactobacillus salivarius.
8. A method of inhibiting acid production by a cariogenic bacterium in a subject suffering from dental caries comprising administering to the subject a bacterial composition comprising a bacterium of genus Rothia.
9. The method of claim 8 , wherein the bacterial composition comprises at least one bacterium selected from a bacterium of species Rothia denticariosa , a bacterium of Rothia aeria , and a bacterium of Rothia mucilaginosa.
10. The method of claim 8 , wherein the bacterial composition does not inhibit growth of a cardiogenic bacterium.
11. The method of claim 8 , wherein the cariogenic bacterium is a bacterium of species Streptococcus mutans, Streptococcus infantis, Streptococcus sanguinis SK36, or Streptococcus sobrinus.
12. The method of claim 11 , wherein the bacterium of species Streptococcus mutans is a bacterium of strain ATCC UA140 or ATCC UA159.
13. The method of claim 8 , wherein the cariogenic bacterium is a bacterium of genus Lactobacillus.
14. The method of claim 13 , wherein the bacterium of genus Lactobacillus is a bacterium of species Lactobacillus fermentum and Lactobacillus salivarius.
15. The method of claim 1 , wherein the bacterial composition treats or reduces severity of dental caries in the subject.
16. The method of claim 1 , wherein the bacterial composition is administered orally.
17. The method of claim 1 , wherein the bacterial composition is administered orally.
18. The method of claim 8 , wherein the bacterial composition is administered orally.