Materials and methods relating to stabilised polymeric silicate compositions
Stabilised and aquated polymeric silicate compositions are described in which the compositions are poorly condensed compositions in which the silicates are resorbable and are capable of undergoing efficient dissolution to provide bioavailable soluble silicic acid. In particular, stabilised and aquated polymeric silicates are described that are capable of intravenous delivery, useful in the treatment of cancer or systemic infection, or for topical administration, e.g. in the form of a solid or semi-solid ointment useful in the treatment of wounds or the prevention of bacterial infection.
1. A method of promoting wound healing and/or treating or preventing bacterial infection in a subject, the method comprising administering to the subject a stabilised polymeric silicate composition comprising polymeric silicic acid, poorly condensed nanosilicate particles having mean diameters of 20 nm or less and a stabilising agent comprising a polyalkylene glycol to inhibit formation of condensed silicates, wherein the composition is aquated and is formulated as a cream or an ointment for topical administration, and wherein the pH of the composition is between 5.5 and 8.0.
2. The method of claim 1 , wherein the polyalkylene glycol is polyethylene glycol (PEG).
3. The method of claim 1 , wherein the composition comprises at least 5% water.
4. The method of claim 1 , wherein the nanosilicate particles have a mean diameter of 10 nm or less.
5. The method of claim 1 , wherein the composition has a concentration of silicon of 2.5 mM or more.
6. The method of claim 1 , wherein the composition is formulated as a cream or ointment by mixing the composition with a solid or semi-solid matrix.
7. The method of claim 6 , wherein the solid or semi-solid matrix comprises one or more polyalkylene glycol polymers or one or more hydroxyethyl cellulose gels.
8. The method of claim 1 , wherein the composition is stable for 1 month or more.
9. The method of claim 1 , wherein the composition comprises one or more metal cations selected from Cu 2+ , Ag + , Ca 2+ , Mg 2+ , Fe 3+ and/or Zn 2+ .
10. The method of claim 1 , wherein the composition is resorbable as determined in an in vitro dissolution assay in which at least 25% of the composition dissolves in 24 hours in HEPES buffer.
11. The method of claim 10 , wherein the in vitro dissolution assay is a molybdic acid assay for determining the soluble silicic acid fraction.
12. The method of claim 1 , wherein the subject is a human subject.
13. The method of claim 1 , wherein the subject is a non-human animal.
14. A method of treating a subject having osteoporosis, osteopenia, musculoskeletal and joint disorders, cancer, skin conditions, vascular diseases, cardiovascular diseases, coronary heart diseases, inflammatory diseases, autoimmune diseases, Alzheimer's disease, cognitive impairment, infections, wounds, ulcers, gastrointestinal disorders, liver disease, kidney disease, immune related disorders and/or hormone related disorders, the method comprising administering to the subject a stabilised polymeric silicate composition comprising polymeric silicic acid and poorly condensed nanosilicate particles having mean diameters of 20 nm or less, wherein the silicate composition is aquated and further comprises a stabilising agent comprising a polyalkylene glycol and/or a sugar, wherein the stabilising agent inhibits formation of condensed silicates, and wherein the pH of the composition is between 5.5 and 8.0.
15. The method of claim 14 , wherein the polyalkylene glycol is polyethylene glycol (PEG).
16. The method of claim 14 , wherein the sugar is sucrose.
17. The method of claim 14 , wherein the composition comprises at least 5% water.
18. The method of claim 14 , wherein the nanosilicate particles have a mean diameter of 10 nm or less.
19. The method of claim 14 , wherein the composition has a concentration of silicon of 2.5 mM or more.
20. The method of claim 14 , wherein the composition is stable for 1 month or more.
21. The method of claim 14 , wherein the composition comprises one or more metal cations selected from Cu 2+ , Ag + , Ca 2+ , Mg 2+ , Fe 3+ and/or Zn 2+ .
22. The method of claim 14 , wherein the composition is resorbable as determined in an in vitro dissolution assay in which at least 25% of the composition dissolves in 24 hours in HEPES buffer.
23. The method of claim 22 , wherein the in vitro dissolution assay is a molybdic acid assay for determining the soluble silicic acid fraction.
24. The method of claim 14 , wherein the skin condition is selected from burns, wounding or action of pathogens or of caustic chemicals, sun burn, psoriasis, eczema and dermatitis.
25. The method of claim 14 , wherein the hormone related disorder is diabetes.
26. The method of claim 14 , wherein the composition is for oral delivery to bind cations in the gut.
27. The method of claim 14 , wherein the composition is for intravenous delivery for the treatment of cancer.
28. The method of claim 14 , wherein the composition is for intravenous delivery for the treatment of infections.
29. The method of claim 14 , wherein said administering is parenteral.
30. The method of claim 29 , wherein said parenteral administering is intravenous (IV), intraperitoneal (IP) or intramuscular (IM).
31. The method of claim 29 , wherein said parenteral administering is intravenous via an intravenous drip.
32. A silicate-containing supplement comprising a stabilised polymeric silicate composition comprising polymeric silicic acid and poorly condensed nanosilicate particles having mean diameters of 20 nm or less, wherein the composition is in the form of a liquid filled capsule and further comprises a stabilising agent that comprises a polyalkylene glycol and/or a sugar, wherein the stabilising agent inhibits formation of condensed silicates, and wherein the pH of the composition is between 5.5 and 8.0.
33. The silicate-containing supplement of claim 32 , wherein the composition is for direct oral administration.
34. A method of improving the appearance of hair, skin, or nails, comprising administering to a subject the silicate-containing supplement of claim 32 .