CONFORMAL ELECTRODE ARRAYS FOR ELECTROPHYSIOLOGIC RECORDING AND NEURAL STIMULATION WITHIN THE CEREBRAL VENTRICLES AND CEREBRAL VASCULATURE
The present disclosure relates to an array of electrodes and integrated electronics on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, blood vessels of the brain, and/or into other body cavities, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain and/or body, and precise electrical stimulation of tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain, nervous system, and/or elsewhere in the body.
1 . An integrated circuit comprising a size and being configured according to a flexibility requirement for catheter-based delivery to electrophysiologically relevant anatomic targets.
2 . The integrated circuit of claim 1 , wherein the electrophysiologically relevant anatomic targets comprise a brain.
3 . The integrated circuit of claim 1 , wherein the electrophysiologically relevant anatomic targets comprise an area of the nervous system.
4 . The integrated circuit of claim 1 , wherein the electrophysiologically relevant anatomic targets comprise a heart.
5 . The integrated circuit of claim 1 , wherein the flexibility requirement of the integrated circuit has a tolerable bending radius of approximately 20 cm or less.
6 . The integrated circuit of claim 1 , wherein a longest rectangular dimension of the size of the integrated circuit is approximately 2 mm or less.
7 . The integrated circuit of claim 1 , wherein the integrated circuit has a multiplexer array.
8 . The integrated circuit of claim 7 , wherein the multiplexer array has an aspect ratio 1:r.
9 . The integrated circuit of claim 8 , wherein 1/r is less than 1.
10 . The integrated circuit of claim 9 , wherein r is determined based on a total electronics layout area divided by (2 mm) 2 .
11 . The integrated circuit of claim 1 , wherein the integrated circuit is configured for use with flexible electrode arrays implanted in a human body.
12 . The integrated circuit of claim 1 , configured for use in a neural interface or brain-machine interface.
13 . The integrated circuit of claim 1 , configured for use in a signal conditioning unit for recording and processing individual-neuronal activity, neuronal population activity, local field activity, electrophysiologic signals in other bandwidth ranges, or some combination thereof.
14 . The integrated circuit of claim 1 , configured for use in cardiac electrophysiology.
15 - 77 . (canceled)