METHODS OF TREATING MIXED DYSLIPIDEMIA
The present disclosure relates to, inter alia, methods of treating mixed dyslipidemia with ethyl eicosapentaenoate.
1 . A method of reducing triglycerides in a subject with triglyceride levels of greater than 500 mg/dl, said method comprising administering to said subject an effective amount of icosapent ethyl for a period of time effective to reduce triglyceride levels, wherein said subject is not receiving an anticoagulant/antiplatelet therapy.
2 . The method of claim 1 , wherein the subject is on statin therapy.
3 . The method of claim 1 , wherein the subject has a baseline LDL-C level of about 40 mg/dL to about 100 mg/dL.
4 . The method of claim 1 , wherein the ethyl icosapentate is present in a pharmaceutical composition and the ethyl icosapentate comprises at least about 96 wt. % of all omega-3 fatty acids in the pharmaceutical composition.
5 . The method of claim 4 , wherein about 1 g of the pharmaceutical composition is present in each of 4 capsules.
6 . The method of claim 1 , wherein the subject is administered the icosapent ethyl for a period of at least about 2 years.
7 . The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels of at least about 5%.
8 . The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels of at least about 10%.
9 . The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels of at least about 15%.
10 . The method of claim 1 , wherein the subject exhibits a reduction in triglyceride levels of at least about 20%.