Treatment of cholestatic pruritus
Treatment of cholestatic pruritus by therapy with seladelpar or a salt thereof.
1 . A method of treating cholestatic pruritus associated with a hepatobiliary disease during treatment of the hepatobiliary disease by administering a therapeutically effective amount of seladelpar or a salt thereof.
2 . The method of claim 1 where the seladelpar or a salt thereof is a seladelpar L-lysine salt.
3 . The method of claim 2 where the seladelpar L-lysine salt is seladelpar L-lysine dihydrate salt.
4 . The method of claim 1 where the seladelpar or a salt thereof is administered orally.
5 . The method of claim 1 where the amount of seladelpar or a salt thereof is between 0.5 mg/day and 50 mg/day, when the amount is calculated as seladelpar.
6 .- 7 . (canceled)
8 . The method of claim 1 where the amount of seladelpar or a salt thereof is 2 mg/day, 5 mg/day, or 10 mg/day.
9 . (canceled)
10 . The method of claim 8 where the amount of seladelpar or a salt thereof is 5 mg/day.
11 . The method of claim 8 where the amount of seladelpar or a salt thereof is 10 mg/day.
12 . The method of claim 1 where the seladelpar or a salt thereof is administered once/day.
13 .- 14 . (canceled)
15 . The method of claim 1 where the hepatobiliary disease associated with the pruritus is a hepatocellular cholestasis.
16 . The method of claim 1 where the hepatobiliary disease associated with the pruritus is a cholangiocellular cholestasis.
17 . The method of claim 1 where the hepatobiliary disease associated with the pruritus is an obstructive cholestasis.
18 . The method of claim 1 where the hepatobiliary disease associated with the pruritus is an intrahepatic cholestatic disease.
19 . The method of claim 18 where the intrahepatic cholestatic disease is primary biliary cholangitis, primary sclerosing cholangitis, progressive familial intrahepatic cholestasis, or Alagille syndrome.
20 . The method of claim 19 where the cholestatic pruritus is associated with primary biliary cholangitis.
21 . The method of claim 19 where the cholestatic pruritus is associated with primary sclerosing cholangitis.
22 . The method of claim 19 where the cholestatic pruritus is associated with progressive familial intrahepatic cholestasis.
23 . The method of claim 19 where the cholestatic pruritus is associated with Alagille syndrome.
24 . The method of claim 1 where the hepatobiliary disease associated with the pruritus is the intrahepatic cholestasis of pregnancy.