Use of cannabidiolic acid in the treatment of autism spectrum disorder and associated disorders
The present invention relates to the use of cannabidiolic acid (CBDA) in the treatment of autism spectrum disorder (ASD) and ASD-associated disorders, such as Fragile X syndrome (FXS); Rett syndrome (RS); or Angelman syndrome (AS). CBDA has been shown to be particularly effective in improving cognitive dysfunction in rodent models of ASD, FXS, RS and AS. The CBDA is preferably substantially pure. It may take the form of a highly purified extract of cannabis such that the CBDA is present at greater than 95% of the total extract (w/w) and the other components of the extract are characterised. Alternatively, the CBDA is synthetically produced.
1. A method for treating cognitive dysfunction in a subject in need thereof, the method comprising administering a therapeutically effective amount of cannabidiolic acid (CBDA) to the subject, wherein the CBDA is present as a highly purified extract of cannabis which comprises at least 95% w/w CBDA, or is present as a synthetic CBDA and wherein cognitive dysfunction is a dysfunction of short or long term memory loss.
2. The method according to claim 1 , wherein the cognitive dysfunction is cognitive dysfunction in an autistic spectrum disorder (ASD) or in an ASD-associated disorder.
3. The method according to claim 1 , wherein the extract comprises less than 0.15% THC.
4. The method according to claim 1 , wherein the dose of CBDA is greater than 0.01 mg/kg/day.
5. The method according to claim 4 , wherein the dose of CBDA is between 1 to 30 mg/kg/day.
6. The method according to claim 1 , wherein the CBDA is administered as an oral formulation.