Granted Patent
B2
US 11,858,939 · App. 17/134,875 · Granted Jan 2, 2024
Hetero-halo inhibitors of histone deacetylase
Inventors:
Martin R. Jefson (Stonington, CT); John A. Lowe, III (Stonington, CT); Fabian Dey (Basel, CH); Andreas Bergmann (Gauting, DE); Andreas Schoop (Grafrath, DE); Nathan Oliver Fuller (Arlington, MA)
Assignee:
Alkermes, Inc.
C07D487/04A61K31/13A61K31/167A61K31/27A61K31/351A61K31/40A61K31/415A61K31/4155A61K31/4192A61K31/421A61K31/426A61K31/427A61K31/435A61K31/437A61K31/44A61K31/444A61K31/445A61K31/4433A61K31/4439A61K31/496A61K31/4965A61K31/4985A61K31/50A61K31/505A61K31/506A61K31/5377A61K31/55A61K45/06C07D207/06C07D309/14C07D401/12C07D401/14C07D403/12C07D405/12C07D409/12C07D413/14C07D417/12C07D417/14C07D471/10C07D487/10C07D491/107C07D513/04
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Abstract
This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula I, II or any of Compounds 100-128 or any of those in Tables 2 or 3) accordingly are useful for treating, alleviating, or preventing a condition in a subject such as a neurological disorder, memory or cognitive function disorder or impairment, extinction learning disorder, fungal disease or infection, inflammatory disease, hematological disease, or neoplastic disease, or for improving memory or treating, alleviating, or preventing memory loss or impairment.
Claims (2)
1. A compound having the formula:
or a pharmaceutically acceptable salt thereof.
Assignments (5)
SECURITY INTEREST
Recorded Feb 13, 2026
From: ALKERMES, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 073790/0950 →
RELEASE OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (072656/0509)
Recorded Feb 13, 2026
From: JPMORGAN CHASE BANK, N.A., AS ADMINISTRATIVE AGENT
To: ALKERMES, INC.
Reel/Frame 074858/0481 →
SECURITY INTEREST
Recorded Oct 23, 2025
From: ALKERMES, INC.
To: JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT
Reel/Frame 072656/0509 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 27, 2021
From: JEFSON, MARTIN R.; LOWE, JOHN A., III; DEY, FABIAN; BERGMANN, ANDREAS; SCHOOP, ANDREAS; FULLER, NATHAN OLIVER
To: RODIN THERAPEUTICS, INC.
Reel/Frame 056983/0796 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 27, 2021
From: RODIN THERAPEUTICS, INC.
To: ALKERMES, INC.
Reel/Frame 056983/0832 →