Oral octreotide therapy and contraceptive methods
This invention relates to methods of administering oral octreotide therapy to a female subject relating to avoidance of combined oral contraceptives or use of a back-up method for contraception.
1. A method of administering oral octreotide to a female subject in need thereof wherein said subject is also in need of a contraceptive method, comprising
(a) administering to the subject oral octreotide; and
(b) counseling the subject to avoid concomitant use of a combined oral contraceptive.
2. The method of claim 1 , wherein the combined oral contraceptive comprises levonorgestrel.
3. A method of administering oral octreotide to a female subject in need thereof wherein said subject is administered a combined oral contraceptive, comprising
(a) administering to the subject oral octreotide; and
(b) counseling the subject to use a back-up method of contraception or to use an alternative non-hormonal method of contraception.
4. The method of claim 3 , wherein the combined oral contraceptive comprises levonorgestrel.
5. The method of claim 1 , wherein the subject has acromegaly.
6. The method of claim 1 , wherein the subject has severe diarrhea or flushing episodes associated with metastatic carcinoid tumor.
7. The method of claim 3 , wherein the subject has acromegaly.
8. The method of claim 3 , wherein the subject has severe diarrhea or flushing episodes associated with metastatic carcinoid tumor.
9. A method of administering oral octreotide to a female subject in need thereof wherein said subject is also in need of a contraceptive method, comprising
(a) administering to the subject oral octreotide; and
(b) counseling the subject to avoid concomitant use of a contraceptive which comprises levonorgestrel or to use a back-up method of contraception or to use an alternative method of contraception.
10. The method of claim 9 , wherein the contraceptive which comprises levonorgestrel is an oral contraceptive.
11. The method of claim 9 , wherein the contraceptive which comprises levonorgestrel is not an oral contraceptive.
12. The method of claim 11 , wherein the contraceptive is an intrauterine device.