IP Library › Granted Patent US 11,091,447
Granted Patent B2
US 11,091,447 · App. 17/139,188 · Granted Aug 17, 2021

UBE2K modulators and methods for their use

Inventors: Vivek K. Vishnudas (Bedford, MA); Dinesh U. Chimmanamada (Arlington, MA); Santosh A. Khedkar (Lexington, MA)
Assignee: Berg LLC
C07D249/08C07D405/12
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Quick Facts
Patent No.
US 11,091,447
App. No.
17/139,188
Granted
Aug 17, 2021
Kind
B2
Abstract

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.

Claims (16)

1. A compound of the Formula:

or a pharmaceutically acceptable salt of any of the foregoing.

2. The compound of claim 1 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 1 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

5. A pharmaceutical composition comprising a compound of the Formula:

or a pharmaceutically acceptable salt of any of the foregoing; and a pharmaceutically acceptable carrier.

6. The composition of claim 5 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

7. The composition of claim 5 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

8. The composition of claim 5 , wherein the compound is of the Formula:

or a pharmaceutically acceptable salt thereof.

Assignments (5)
SECURITY INTEREST Recorded Aug 29, 2025
From: BPGBIO INC.
To: BERG SURVIVOR’S TRUST; BERG, KARA ANN; THLIVERIS, ANDREW T.
Reel/Frame 072805/0303 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PATENT NUMBER 8147825 WAS ADDED PREVIOUSLY RECORDED AT REEL: 70903 FRAME: 693. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Apr 30, 2025
From: BPGBIO INC.
To: PHOENIX GENESIS LLC
Reel/Frame 071285/0001 →
SECURITY INTEREST Recorded Apr 21, 2025
From: BPGBIO INC.
To: PHOENIX GENESIS LLC
Reel/Frame 070903/0693 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 2, 2023
From: BERG LLC
To: BPGBIO, INC.
Reel/Frame 063842/0405 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 7, 2021
From: VISHNUDAS, VIVEK K.; CHIMMANAMADA, DINESH U.; KHEDKAR, SANTOSH A.
To: BERG LLC
Reel/Frame 054846/0168 →
Continuity (2)
Provisional Application 62956802 · Jan 3, 2020
Related Publication 20210214320A1 · Jul 15, 2021