Diketopiperazine salts for drug delivery and related methods
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
1. A method for the delivery of particles to the pulmonary system comprising:
administering to a patient in need of treatment an effective amount of a dry powder composition by inhalation, the dry powder composition comprising:
a phosphodiesterase type 5 (PDE5) inhibitor; and
a pharmaceutically acceptable salt of a heterocyclic compound which has a structure according to Formula 1:
wherein R 1 or R 2 are independently selected from 4-succinyl-aminobutyl, 4-glutaryl-aminobutyl, 4-maleyl-aminobutyl, 4-fumaryl-aminobutyl, 4-citraconyl-aminobutyl, 4-malonyl-aminobutyl, 4-oxalyl-aminobutyl;
E 1 and E 2 are NH; and
said salt further comprises a cation.
2. The method of claim 1 , wherein said PDE5 inhibitor is selected from the group consisting of sildenafil citrate, vardenafil hydrochloride and tadalafil.
3. The method of claim 1 , wherein said PDE5 inhibitor is tadalafil.
4. The method of claim 1 , wherein said cation is selected from the group consisting of sodium, potassium, calcium, lithium, triethylamine, butylamine, diethanolamine and triethanolamine.
5. The method of claim 1 , wherein said cation is sodium.
6. The method of claim 1 , wherein the dry powder is formed by the removal of a solvent from a solution containing the PDE5 inhibitor, the pharmaceutically acceptable salt of the heterocyclic compound, and the cation.
7. The method of claim 6 , wherein the removal of the solvent is achieved by spray drying.
8. The method of claim 6 , wherein the removal of the solvent is achieved by evaporation.
9. The method of claim 6 , wherein the removal of the solvent is achieved by lyophilization.
10. The method of claim 6 , wherein the dry powder is prepared by a method that includes micronizing a solid to form microparticles of the dry powder.
11. The method of claim 10 , wherein the microparticles of the dry powder are suitable for pulmonary delivery.
12. The method of claim 10 , wherein the microparticles of the dry powder have a rugosity of less than 2.
13. The method of claim 10 , wherein at least 50% of the microparticles have a diameter less than 5 μm.
14. The method of claim 10 , wherein at least 70% of the microparticles have a diameter less than 5 μm.
15. The method of claim 10 , wherein the microparticles have a rugosity of less than 2.
16. The method of claim 10 , wherein the microparticles are suitable for pulmonary delivery.
17. The method of claim 1 , wherein the dry powder is formulated into a solid dosage form.
18. The method of claim 1 , wherein the diketopiperazine is a symmetrical derivative thereof.
19. A method of absorption of PDE5 inhibitor into a circulatory system by the method of claim 1 .
20. A method of immediate and sustained absorption of PDE5 inhibitor into a circulatory system by the method of claim 1 , wherein the dry powder composition is a combination comprising cations formed from sodium and calcium.