MODIFIED RELEASE FORMULATIONS CONTAINING DRUG-ION EXCHANGE RESIN COMPLEXES
An aqueous liquid suspension containing a coated drug—ion exchange resin complex comprising a core composed of an amphetamine complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated amphetamine—ion exchange resin complex is provided. The coated amphetamine—ion exchange resin complex is in admixture with a polymer to form a matrix. Methods of making the coated complex and the liquid suspension are described.
1 . A modified release coated drug—ion exchange resin complex useful in preparing modified release pharmaceutical composition, said complex comprising a drug bound to a pharmaceutically acceptable ion exchange resin and having a high tensile strength water-permeable, water-insoluble, modified release polymeric barrier coating over the drug—ion exchange resin complex.
2 . A method of treating a patient in need thereof with a pharmaceutically active drug having a modified release profile, said method comprising orally delivering a composition according to claim 1 .