Compositions and methods for lowering triglycerides
In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
1. A method of lowering triglycerides in a subject on stable statin therapy having type 2 diabetes mellitus and fasting triglycerides of about 200 mg/dl to about 500 mg/dl, the method comprising administering to the subject a composition comprising about 4 g of ethyl eicosapentaenoate per day for a period of time effective to reduce the fasting triglycerides in the subject wherein the composition comprises at least 96% by weight ethyl eicosapentanoate.
2. The method of claim 1 , wherein the subject has serum LDL-C levels of about 40 mg/dl to about 115 mg/dl.
3. The method of claim 1 , wherein the composition is administered to the subject 1 to 4 times per day.
4. The method of claim 3 , wherein the composition is present in one or more capsules.
5. The method of claim 1 , wherein the composition contains not more than about 10% by weight of docosahexaenoic acid or derivatives thereof.
6. The method of claim 1 , wherein the period is about 1 week to about 12 weeks.
7. The method of claim 1 , wherein the period is about 12 weeks.