Antigen binding proteins that bind PD-L1
There is disclosed anti-PD-L1 IgG class antibodies that have an improved ability to be manufactured at higher yields. More specifically, there is disclosed human antibodies that bind PD-L1, PD-L1-binding fragments that can be manufactured at higher yields.
1. One or more polynucleotides encoding an antibody or antibody fragment that binds to a PD-L1 epitope, wherein the antibody or antibody fragment comprises a heavy chain variable domain comprising a CDR1, a CDR2, and a CDR3 as set forth in the amino acid sequences of SEQ ID NO: 5, SEQ ID NO: 6, and SEQ ID NO: 7, respectively, and comprises a light chain variable domain comprising the amino acid sequence of SEQ ID NO. 2 or SEQ ID NO. 3.
2. The one of more polynucleotides of claim 1 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2.
3. The one of more polynucleotides of claim 1 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 3.
4. The one of more polynucleotides of claim 1 , wherein the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
5. The one of more polynucleotides of claim 1 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
6. The one of more polynucleotides of claim 1 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 3 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
7. The one of more polynucleotides of claim 1 , wherein the one or more polynucleotides encode an IgG antibody.
8. The one of more polynucleotides of claim 7 , wherein the IgG antibody is an IgG1 antibody.
9. The one of more polynucleotides of claim 7 , wherein the IgG antibody is an IgG4 antibody.
10. The one of more polynucleotides of claim 1 , wherein the one or more polynucleotides encode a fully human antibody.
11. The one of more polynucleotides of claim 1 , wherein the one or more polynucleotides encode a Fab fragment.
12. The one of more polynucleotides of claim 1 , wherein the one or more polynucleotides encode a single-chain antibody.
13. The one of more polynucleotides of claim 7 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
14. The one of more polynucleotides of claim 8 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
15. The one of more polynucleotides of claim 9 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
16. The one of more polynucleotides of claim 10 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
17. The one of more polynucleotides of claim 11 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
18. The one of more polynucleotides of claim 12 , wherein the light chain variable domain comprises the amino acid sequence of SEQ ID NO. 2 and the heavy chain variable domain comprises the amino acid sequence of SEQ ID NO. 1.
19. One or more vectors comprising the one or more polynucleotides of claim 1 .